Does Haloperidol interact with Sertraline? (3+ options)

In this article, we will discuss Haloperidol interaction with Sertraline. We will also share the side effects related to interactions between these medicines and how to manage the side effects.

Does Haloperidol interact with Sertraline?

Yes, Haloperidol does interact with Sertraline. Haloperidol is a neuroleptic antipsychotic medicine whereas Sertraline is an antidepressant.

Haloperidol is used for controlling motor and speech and is typically prescribed in schizophrenia, while Sertraline (Zoloft) is prescribed in the treatment of depression and anxiety. Using Haloperidol and sertraline in combination can cause irregular cardiac rhythms which could be fatal although it is a rare adverse effect.

How do Haloperidol and Sertraline interact in the body?

The interaction between Haloperidol and Sertraline can be through the effects of these medications on various neurotransmitters in the brain, such as Dopamine and Serotonin.

Sertraline known as a Selective serotonin reuptake inhibitor, primarily works in blocking the reuptake of serotonin. This results in inhibiting the reabsorption and increasing levels of serotonin in the brain which is subjected to reduce symptoms associated with depression.

Sertraline works on serotonin and does not directly affect dopamine or any other neurotransmitters.

Haloperidol, on the other hand, acts as a dopamine antagonist. However, it has some binding affinity with serotonin receptors which can result in increased levels of serotonin in synaptic cleft causing side effects.

When both of these medications are taken in combination this can result in possible effects on serotonin levels which cause some serious side effects such as serotonin syndrome, tardive dyskinesia and extrapyramidal symptoms, although these side effects are rarely observed.

It is better to communicate with your healthcare provider if you are taking Haloperidol in combination with Sertraline.

What does research suggest?

One clinical study suggested that Haloperidol when co-administered with sertraline, increases Haloperidol plasma concentration but improvement was observed in extrapyramidal symptoms and negative effects. any changes in symptoms and side effects were not observed in this study. (1)

Another study presents that Haloperidol should not be co-administered with the drugs that cause prolongation of QT interval particularly given in high doses or intravenously.

It is advised to seek medical help if the patient suffers from lightheadedness, palpitations, dizziness, irregular cardiac rhythms, and syncope (fainting or passing out). (2,3)

However, Haloperidol may be co-administered with Sertraline in certain medical conditions to achieve therapeutic effect but one should seek medical advice from a doctor before using these medications as a combination therapy as it can cause major side effects which can be rarely observed.

Potential side effects of taking Haloperidol and Sertraline together

Haloperidol taken in combination with Sertraline can produce side effects in some people. Some rare side effects observed when Haloperidol interacts with Sertraline are:

  • Irregular cardiac rhythms
  • Palpitations
  • Confusion
  • Fever
  • Syncope (fainting)
  • Nausea
  • Diarrhoea
  • Dizziness
  • Shortness of breath.

What are alternative options to Haloperidol while taking Sertraline?

If you are taking Sertraline (Zoloft) and need an alternative option to Haloperidol for psychosis or Schizophrenia, several options can generally be considered safe options to use in combination with Sertraline.

Essentially it is considered to reach out to your healthcare provider before starting a new medicine. Some of the alternatives of Haloperidol while administering Sertraline:

Atypical Antipsychotic medications:

To manage the symptoms of bipolar disorder and schizophrenia atypical antipsychotic medicines can be used in combination with Sertraline. E.g.: Clozapine is used in combination treatment with Sertraline for mental health conditions.

Anti-anxiety medications:

Antianxiety medications can be used for short-term treatment of anxiety such as Lorazepam, Benzodiazepines, or clonazepam. However, these are sporadically administered because it has the potential for dependence and should be used under medical guidance.

Mood Stabilizers:

Medication that helps in stabilizing mood can be used in adjunct with sertraline for episodes of depression in bipolar disorder such as Lithium.

Although haloperidol alternative options are available it is considered to take proper medical guidance before starting any new medication.


In this article, we discussed whether Haloperidol interacts with Sertraline. We shared how medications interact and their possible side effects.

Thus, adjunct therapy of Haloperidol and Sertraline should be started under medical supervision, this will help in the management of medications.

Was this helpful?

Thanks for your feedback!



Lee MS, Han CS, You YW, Kim SH. Co-administration of sertraline and haloperidol. Psychiatry Clin Neurosci. 1998 Dec;52 Suppl:S193-8. doi: 10.1111/j.1440-1819.1998.tb03220.x. PMID: 9895145.


Wilt JL, Minnema AM, Johnson RF, Rosenblum AM. Torsade de pointes associated with the use of intravenous haloperidol. Ann Intern Med. 1993 Sep 1;119(5):391-4. doi: 10.7326/0003-4819-119-5-199309010-00007. PMID: 8338292.


Frits Huyse, Rob Strack Van Schijndel HALOPERIDOL AND CARDIAC ARREST, Lancet, Volume 332, Issue 8610,1988, Pages 568-569, ISSN 0140-6736,

Find a supportive therapist who can help with Depression.

Discover the convenience of BetterHelp, an online therapy platform connecting you with licensed and accredited therapists specialized in addressing issues such as depression, anxiety, relationships, and more. Complete the assessment and find your ideal therapist within just 48 hours.


AskYourPharm is user-supported. We may earn a commission if you sign up for BetterHelp’s services after clicking through from this site