Does Ginseng Interact With Wellbutrin? (5 Tips)

By Ivan Kahwa

Page last updated: 07/02/2024 | Next review date: 07/02/2026

Author bio

Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.

Mr Ivan Kahwa’s Highlights:

Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.

Professional Experience:

Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.

With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.

With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.

Education:

2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.

2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.

2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.

Publications:

▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7

▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60

▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.

https://ethnobotanyjournal.org/index.php/era/article/view/4683

▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.

https://doi.org/10.53388/TMRIM202307004

▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.

https://doi.org/10.1186/s43094-021-00296-2

▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.

https://doi.org/10.5799/jmid.951600

Published book Chapter

▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.

https://doi.org/10.1016/B978-0-323-91942-5.00012-4

Submitted manuscripts Under Review:

▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience

▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine

▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology

Submitted book chapters under review

1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.

2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press

You can view my works on the following professional sites:

Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa

Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en

ORCID: https://orcid.org/0000-0002-6440-3437

Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159

Ivan Kahwa

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In this article, we aim to address the question: Does ginseng interact with Wellbutrin? We will delve into research findings and the potential side effects associated with combining ginseng and Wellbutrin.

Does ginseng interact with Wellbutrin?

Yes, ginseng can interact with Wellbutrin. It is generally recommended to avoid ginseng when using drugs that stimulate the central nervous system (CNS), such as Wellbutrin. (1)

Combining ginseng with Wellbutrin can result in synergistic side effects, including increased anxiety, agitation, tremors, and headaches, among other symptoms. This combination may intensify side effects compared to using either substance alone. (1,3)

Ginseng also has the potential to affect the therapeutic outcomes of Wellbutrin. However, it’s important to note that research on these interactions is less extensive than we’d prefer. Nevertheless, as a precaution, many healthcare professionals advise against using ginseng alongside Wellbutrin.

What does research suggest?

Research studies indicate that stimulant drugs like Wellbutrin and ginseng should not be used together as they both accelerate the nervous system, potentially leading to jitteriness and exacerbating side effects like increased heart rate and high blood pressure. (1)

A phase IV clinical trial, analysing FDA data through eHealthMe, reported drug interactions between ginseng and Wellbutrin XL, although only a few people have reported such interactions. (2)

Ginseng is commonly used to reduce stress, enhance cognitive functions of the brain and improve fatigue. A study revealed that ginseng effectively combats stress, a leading factor in depression. (4)

Another study highlighted the substantial role of ginseng in addressing depression, suggesting its potential as an antidepressant. The research pointed out the neuroprotective qualities of ginseng, which may assist in preventing depression. (5)

A review article proposed that ginseng’s neuroprotective properties could be beneficial in preventing depression. It emphasised that ginseng might indirectly alleviate depression by enhancing memory, which can mitigate anxiety. (6)

What are the potential side effects of taking ginseng with Wellbutrin?

Both ginseng and Wellbutrin are known to have neurostimulant and neuroprotective properties, and when combined, they can potentiate certain side effects due to their overlapping effects on the nervous system.

It’s crucial to be cautious when using two substances with similar mechanisms of action, as this can increase the risk of side effects, including (1,2,3)

Psychological side effects:

When combining ginseng and Wellbutrin, one should be aware of potential psychological side effects. This combination can lead to increased anxiety, jittering, and dizziness.

You might experience tremors, which are involuntary shaking or trembling, often affecting your hands or other parts of your body. Palpitations and headaches are also common side effects.

You might also experience agitation, which can manifest as restlessness or an overall sense of unease, sleep disturbances, such as insomnia or other sleep-related problems, could also be triggered by this combination.

Gastrointestinal side effects

Ginseng and Wellbutrin may cause gastrointestinal distress in some individuals. This discomfort can manifest as digestive issues, including stomach discomfort, dry mouth, decreased appetite, nausea, or diarrhoea. Being mindful of these potential effects can help you manage any gastrointestinal symptoms more effectively.

How to manage the side effects of ginseng with Wellbutrin?

If you have combined ginseng with Wellbutrin and are currently experiencing side effects or have concerns about the potential consequences, here’s what you should do to address the situation effectively:

Contact your healthcare provider immediately if you encounter side effects. They can assess your condition and recommend appropriate actions.
Refrain from consuming alcohol and caffeine as they can worsen side effects. Staying away from these substances can help alleviate discomfort. (1)
Avoid taking more doses of ginseng or Wellbutrin, and don’t introduce any new supplements without the guidance of your doctor. Taking further doses independently can compound side effects.
Drink plenty of water to remain well-hydrated. Adequate hydration can mitigate some side effects, especially those related to dry mouth or increased heart rate.
Comply with the advice and instructions provided by your healthcare provider. This may include potential adjustments in medication, dosage, or discontinuation. Trust their expertise to manage your situation effectively.

Conclusion

In conclusion, combining ginseng with central nervous system (CNS) stimulant drugs like Wellbutrin should be cautiously approached. This combination can result in various side effects, including agitation, anxiety, headaches, and gastrointestinal discomfort.

To avoid these risks, it’s crucial to avoid caffeine and alcohol while using this combination. You should also promptly inform your healthcare provider if you have taken the combination and are experiencing side effects. Prioritising your health and safety is paramount when considering such interactions.