Does Gabapentin increase blood sugar? 

Does Gabapentin increase blood sugar? 

No, Gabapentin is not commonly associated with increased blood sugar levels. Even if some people have experienced this side effect, it was quite insignificant. 

In fact, Gabapentin is safely used by diabetic patients for the management of neuropathic pain. It wouldn’t have been this way if Gabapentin was associated with high blood sugar levels. Gabapentin is generally not known for causing an increase in blood sugar levels or blood pressure

According to some research studies, Gabapentin can significantly lower your blood glucose levels. The study observed the hypoglycemic effects of Gabapentin on both diabetic and non-diabetic patients, and it was concluded that some people experienced severe hypoglycemia at the end of the study (1,2). 

This indicates that Gabapentin can cause a number of different effects in different individuals. Just make sure you monitor your side effects properly and report them to your healthcare provider, and don’t stop the medication abruptly. 

What factors can affect your blood sugar levels while taking Gabapentin?

While Gabapentin itself is not known to directly increase blood sugar levels, certain factors can affect your blood sugar levels while taking the medication. These factors include:

Coexisting conditions

If you have an underlying medical condition such as diabetes or impaired kidney function, it can impact your blood sugar regulation, and the effects may be influenced by the combination of Gabapentin and your existing condition.

Other medications

Concurrent use of other medications, especially those known to affect blood sugar levels (such as certain antipsychotics or corticosteroids), can potentially influence your blood sugar levels when taken alongside Gabapentin.

Lifestyle factors

Your diet, physical activity level, and overall lifestyle habits can play a role in your blood sugar management. Changes in these factors can affect your blood sugar levels independently of Gabapentin.

What to do if your blood sugar is going high while taking Gabapentin? 

Reach out to your doctor or healthcare team, if you notice that your blood sugar levels are rising while taking Gabapentin. Your doctor can provide guidance and evaluate whether there are other underlying factors contributing to the increase.

It is also important to discuss the possibility of interactions between Gabapentin and any other medications you are taking. Certain medications may affect blood sugar levels, and adjustments or alternatives may be necessary.

Furthermore, you should evaluate your dietary habits and consider making adjustments to help manage blood sugar levels (3,4). Focus on consuming a balanced diet with controlled portions of carbohydrates, sugars, and high-fibre foods. 

It is also important to monitor your blood sugar levels consistently, especially during periods of concern. This can help identify patterns and fluctuations, providing valuable information for your healthcare provider to make informed decisions.

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Scholl JH, van Eekeren R, van Puijenbroek EP. Six cases of (severe) hypoglycaemia associated with gabapentin use in both diabetic and non-diabetic patients. Br J Clin Pharmacol. 2015 May;79(5):870-1. doi: 10.1111/bcp.12548. PMID: 25387462; PMCID: PMC4415723.


Hayes WJ, Ferdinand A, Neabore S, Kappes JA, Hayes KM, Berendse J. Patient Case Report: Gabapentin-Induced Hypoglycemia. J Pharm Pract. 2022 Apr;35(2):298-301. doi: 10.1177/0897190020961229. Epub 2020 Sep 29. PMID: 32990167.


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