Does Gabapentin have Aspirin in it?

Does Gabapentin have Aspirin in it?

No, Gabapentin does not have Aspirin in it. These two medications are entirely different from one another and you can’t possibly compare them. Gabapentin is a gamma-aminobutyric acid (GABA) analogue, whereas Aspirin is a non-steroidal anti-inflammatory medication. 

Gabapentin is a prescription medication, but you can find Aspirin over the counter. Both of these meds work in entirely different ways and have different side effect profiles. 

Understanding the differences between Gabapentin and Aspirin

Gabapentin is quite different from Aspirin. Let’s take a look at the basic difference between these two medications:

Mechanism of action and clinical efficacy

Gabapentin is an antiepileptic medication which is prescribed to control the intensity and frequency of epileptic seizures. Gabapentin can also be used for the management and treatment of anxiety and nerve pain(1)

Gabapentin, being a GABA analogue, enhances the activity of the inhibitory system and controls the excessive electrical activity in your brain. This way, the abnormal neuronal firing is controlled, which in turns control your anxiety and convulsions. 

Aspirin, on the other hand, is an OTC painkiller and anti-inflammatory medication. It inhibits the synthesis of Prostaglandins, which are important mediators of pain and inflammation(2)

Aspirin can also reduce fever to some extent and can be used as a blood thinner in patients with coronary artery diseases.

Side effect profiles

Gabapentin and Aspirin, like every other medication on this planet, are associated with some side effects. Let’s take a look at them. 

Side effects of Gabapentin

  • Xerostomia or dry mouth 
  • Weight gain 
  • Dizziness 
  • Somnolence
  • Swollen hands and feet
  • Headache
  • Vision problems
  • Diarrhoea 
  • Cloudy mind
  • Fatigue
  • Tremors 
  • Confusion
  • Joint pain 
  • Abdominal pain 
  • Flatulence and bloating
  • Unsteadiness
  • Muscle twitching 
  • Constipation 
  • Back pain
  • Increased appetite 
  • Fever

Rare and serious side effects include:

  • Suicidal behaviour 
  • Impaired motor coordination
  • Reduced heart rate 
  • Thrombocytopenia or decreased levels of platelets
  • Water retention
  • Rhabdomyolysis – a condition associated with an abnormal breakdown of muscles
  • Convulsions 
  • Swelling or tenderness in different parts of the body.
  • An allergic reaction 

Side effects of Aspirin 

  • Nausea
  • Vomiting 
  • Abdominal pain
  • Acid reflux 
  • Flatulence 

Rare and serious side effects include:

  • An allergic reaction or hypersensitivity 
  • Arrhythmia or abnormal heartbeat
  • Irregular breathing 
  • Tremors 
  • Bloody vomiting 
  • Loss of hearing
  • Black or tarry stools – indicating gastrointestinal bleeding
  • Ulceration 

Final words 

Make sure you use Gabapentin only if prescribed by your healthcare provider, and Aspirin if it doesn’t affect your health. It’s always best to report your side effects to your doctor. Gabapentin is not an easy medication and your body may take some time to adjust. 

Furthermore, Gabapentin should not be discontinued abruptly, as doing so can subject you to side effects, including anxiety, headaches, nausea, ringing in the ears, etc.

As far as Aspirin is concerned, it may not affect you if you take this medication only if you need it. Unlike Gabapentin, Aspirin can cause blood thinning, so it should be used cautiously in people who do not require anticoagulant effects.

Furthermore, long-term use of Aspirin could affect your body negatively and you should talk to your doctor about that – especially if you’re taking Aspirin for a chronic condition. 

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PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 3446, Gabapentin; [cited 2023 Feb. 28]. Available from:


PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 2244, Aspirin; [cited 2023 Feb. 28]. Available from: