Does Fluvoxamine cause insomnia? (3+ tips)

This article discusses the topic of whether Fluvoxamine causes insomnia and explores the research findings on the effects of Fluvoxamine on sleep quality.

The article also offers strategies to reduce Fluvoxamine-induced insomnia. Furthermore, it emphasizes the importance of consulting with a healthcare professional if insomnia persists.

Does Fluvoxamine cause insomnia?

Yes, Fluvoxamine is associated with the potential side effect of insomnia. However, it’s important to recognize that individual responses to the medication can vary, and not everyone will experience this side effect.

If you have concerns or are experiencing difficulties sleeping while taking Fluvoxamine, discussing it with your healthcare provider is recommended for personalized guidance.

How does Fluvoxamine cause insomnia?

Fluvoxamine, as a Selective Serotonin Reuptake Inhibitor (SSRI), can potentially cause insomnia through its effect on serotonin levels in the brain. Serotonin plays a crucial role in regulating mood and sleep-wake cycles.

When Fluvoxamine increases serotonin levels, it may disrupt the balance of neurotransmitters involved in sleep regulation.

The specific mechanisms leading to changes in serotonin levels in the brain can affect the functioning of the sleep-wake system. This disruption may lead to difficulties falling asleep, staying asleep, or experiencing restorative sleep, contributing to insomnia as a side effect.

It’s essential to note that individual responses to medications can vary, and while some people may experience insomnia with Fluvoxamine, others may not be affected in the same way.

If insomnia becomes a concern while taking Fluvoxamine, it’s advisable to discuss the issue with your healthcare provider. Adjustments to the dosage or exploration of alternative treatments may be considered to address the sleep-related side effects.

How Fluvoxamine affect sleep patterns?

Fluvoxamine, being a Selective Serotonin Reuptake Inhibitor (SSRI), plays a role in influencing sleep patterns. The mechanism behind its effect on sleep is connected to the serotonin levels in the brain. Here are the possible factors affecting how Fluvoxamine affects sleep patterns:

  1. Initial Disruptions: When individuals start taking Fluvoxamine, some may experience disruptions in their sleep patterns, commonly in the form of insomnia. This initial disturbance is thought to be a result of the adjustments occurring in the brain as serotonin levels change. It’s important to note that this effect tends to be temporary.
  2. Adaptation Over Time: As the body adjusts to Fluvoxamine, the initial sleep disturbances often improve. This adaptation period varies from person to person, and some individuals may find relief sooner than others. The slow adjustment allows the body to find a new balance, potentially resulting in more stable and improved sleep patterns.
  3. Sedating Effect: On the other hand, some individuals may experience a sedating effect from Fluvoxamine. This means that Fluvoxamine may cause drowsiness, especially in people whose sleep is disrupted by conditions such as anxiety. This sedating quality can be benefecial as it promotes a calming influence that contributes to better sleep quality.

What does research suggest?

A study investigated the effects of Paroxetine and Fluvoxamine on sleep quality in a home setting. Utilizing a 31-day protocol with healthy volunteers, the research demonstrated that Fluvoxamine led to significant sleep disruption. Particularly, the study revealed specific measures such as the eyelid quiescence index, rhythmicity, and eyelid movements per minute during non-rapid eye movement sleep, indicating the distinctive effect of Fluvoxamine on sleep patterns. These findings contribute to the understanding of Fluvoxamine’s effect on sleep quality, confirming previous laboratory observations of SSRI-induced changes in sleep. (1)

Moreover, in an 8-week study, Fluvoxamine demonstrated positive effects on sleep architecture in clinically depressed patients with insomnia, enhancing PSG parameters and reducing insomnia complaints. However, the study highlights an important factor: persistent insomnia increases the risk of remaining depressed by the trial’s end. This emphasizes the importance of monitoring sleep status, especially around the 14-day mark, as an early indicator of Fluvoxamine’s potential efficacy in sustaining mood improvement. (2)

Lastly, in a 12-week study of people using Fluvoxamine for depression at home, changes in sleep patterns were observed. The medication influenced how quickly they entered Rapid Eye Movement (REM) sleep, and most returned to normal by week 12. People felt better subjectively about their sleep over time, especially those who responded well to the treatment. Importantly, the at-home recording of sleep was convenient and didn’t cause much disruption for the participants. (3)

According to these studies, Fluvoxamine showed significant sleep disruption in healthy volunteers, positive effects on sleep architecture in depressed patients, and influenced REM sleep in a 12-week home-based setting. These findings emphasize Fluvoxamine’s impact on sleep patterns and suggest its potential benefits in managing mood disorders.

How to address insomnia caused by Fluvoxamine?

If you’re experiencing insomnia as a side effect of Fluvoxamine, it’s crucial to communicate with your healthcare provider. Here are some steps you can take: (4)

  1. Contact Your Healthcare Provider: Inform your healthcare provider about your insomnia symptoms. They can provide guidance on whether to make adjustments to your medication, such as changing the dosage or trying a different timing for administration.
  2. Timing of Medication: Discuss the timing of your Fluvoxamine dose with your healthcare provider. Sometimes taking the medication earlier in the day can help minimize insomnia, as SSRIs can influence sleep patterns.
  3. Sleep Hygiene Practices: Implement good sleep hygiene practices, such as maintaining a consistent sleep schedule, creating a relaxing bedtime routine, and ensuring your sleep environment is comfortable to rest in.
  4. Avoid Stimulants: Reduce or avoid stimulants like caffeine and nicotine, especially in the evening. These can worsen insomnia.
  5. Limit Screen Time: Reduce exposure to screens (phones, computers, and TVs) before bedtime, as the blue light emitted can interfere with the production of the sleep hormone melatonin.
  6. Relaxation Techniques: Practice relaxation techniques such as deep breathing, meditation, or progressive muscle relaxation to help calm your mind before bedtime.
  7. Consultation with a Sleep Specialist: If insomnia persists, consider consulting a sleep specialist. They can provide more targeted strategies and interventions to improve your sleep.

What to do if Fluvoxamine-induced insomnia doesn’t go away?

If insomnia persists, it’s essential to have a detailed conversation with your healthcare provider. Discuss your specific experiences with insomnia and any challenges you’re facing. Your doctor may consider adjusting the dosage of Fluvoxamine, exploring alternative medications, or incorporating additional sleep aids into your treatment plan. It’s important to communicate openly about the effect on your sleep quality and any concerns you may have.

If modifying the timing of Fluvoxamine or trying other strategies proves ineffective, your healthcare provider may consider the possibility of transitioning to a different medication with potentially fewer effects on sleep. This decision will depend on your individual health circumstances and the overall management of your condition.

Consistent and transparent communication with your doctor is crucial throughout this process. They can provide tailored guidance to address your specific situation, ensuring the most suitable approach to enhance both your mental health and sleep quality.


In my conclusion, if you’re experiencing insomnia due to Fluvoxamine, it’s important to recognize that individual responses vary. Seeking guidance from your healthcare provider is essential. Discussing your specific experience will help you customize potential adjustments or alternative treatments to improve your sleep quality.

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Silvestri R, Pace-Schott EF, Gersh T, Stickgold R, Salzman C, Hobson JA. Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: a home-based Nightcap evaluation during drug administration and withdrawal. J Clin Psychiatry. 2001 Aug;62(8):642-52. doi: 10.4088/jcp.v62n0812. PMID: 11561938.


Hao Y, Hu Y, Wang H, Paudel D, Xu Y, Zhang B. The Effect Of Fluvoxamine On Sleep Architecture Of Depressed Patients With Insomnia: An 8-Week, Open-Label, Baseline-Controlled Study. Nat Sci Sleep. 2019 Nov 4;11:291-300. doi: 10.2147/NSS.S220947. PMID: 31807102; PMCID: PMC6839582.


Wilson SJ, Bell C, Coupland NJ, Nutt DJ. Sleep changes during long-term treatment of depression with fluvoxamine–a home-based study. Psychopharmacology (Berl). 2000 May;149(4):360-5. doi: 10.1007/s002139900362. PMID: 10867963.


NHS Choices. Sleep and tiredness [Internet]. 2023 [cited 2023 Nov 16]. Available from:

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