Does Duloxetine make you feel cold? (3+ tips)

In this article, we will answer the question “Does Duloxetine make you feel cold?”. We will discuss some common side effects of Duloxetine, factors that can trigger cold sensations while taking Duloxetine and how to cope with such sensations. We will also discuss what to do if this problem does not subside.

Does Duloxetine make you feel cold?

Yes, Duloxetine may cause a cold sensation in some individuals. However, as each individual responds differently to different medications, everyone may not experience this side effect.

Duloxetine (Cymbalta) is an antidepressant of the serotonin and norepinephrine reuptake inhibitors (SNRIs) and is used in the treatment of depressive illnesses like major depressive disorder (MDD), generalised anxiety disorder (GAD), fibromyalgia, neuropathic pain and chronic musculoskeletal pain (1,2).

Duloxetine may cause side effects in individuals taking therapy. More common side effects include nausea, diarrhoea, headaches and decreased appetite. One side effect that may be experienced by individuals is chills and cold sensations. The exact mechanism by which Duloxetine causes cold sweats and chills is not known but there is a possibility that they may occur due to the changes in blood pressure caused by Duloxetine.

Such side effects normally occur at the initiation of therapy and subside once your body gets used to the medication. If you still experience these side effects and they cause discomfort you should contact your healthcare provider.

What are user experiences of cold sensations while on Duloxetine?

Various users of Duloxetine report experiencing cold sensations while taking the medication. One user was prescribed this medication for the treatment of neuropathic pain. Duloxetine did help with the pain but has caused cold feet ever since the first dose.

Another user sharing his experience of Duloxetine explained that he experienced a cold sensation and cold sweats while taking the medication.

A user taking Duloxetine for chronic pain also reported having an array of side effects including cold sweats. He claims to have experienced these until Duloxetine was discontinued.

One person taking this medication for anxiety developed the side effect of cold sweats after the first dose. He also described the symptoms and alternate hot and cold flashes which left him with no energy.

One user taking Duloxetine for MDD also experienced cold sweats and shivering when he started taking the medication. The symptoms became so uncomfortable that the drug had to be discontinued.

A user taking Duloxetine 40mg/day for depression also experienced cold sweats and general feelings of cold. He decided to consult his healthcare provider and ask for an alternate medication. 

What factors influence cold sensations while taking Duloxetine?

Some factors that can influence cold sensations while taking Duloxetine are as follows:

Improper diet

A diet lacking proper nutrition may cause cold sensations in the individual taking Duloxetine. Low nutrition and decreased blood glucose levels can trigger such a side effect.

Panic attacks

Sometimes extremes of depression can cause a panic attack. Shivering and chills can also be caused as a result of a panic attack.

Exposure to cold

Exposure to cold weather or any cold environment, in general, can also be a reason for any individual to feel chills or cold sensations. 


A decreased blood sugar level can compromise the amount of body heat generated and produce side effects like shivering, cold and chills.

How to cope with the chills while on Duloxetine?

Some tips and strategies to help you cope with the chills are as follows:

Proper diet

A proper and healthy diet can help you improve your overall health. It also can eliminate malnutrition which can become a reason for your chills.

Layer up

Sometimes the chills or cold sensations are only due to chilly weather. Layering up and keeping yourself warm is the best treatment in such situations.

Balance your sugar levels

If you feel that your sugar levels may be low, try eating candy or drinking juice to improve your sugar levels immediately. This can help you with the shivering and chills.

If you have been diagnosed with diabetes you should take extra care in this regard. If you do not have diabetes but still experience hypoglycemia, you should consult your doctor for a full workup to rule out diabetes.

Light exercise

Having a routine of light walking and exercise in your day can help you with the cold sensations. Muscle movement produces energy and heat which can improve these symptoms.

Maintaining a comfortable temperature

Make sure your room and house are at a comfortable temperature. If it is cold outside you can always turn the thermostat up to keep the indoors at a cosy temperature.

Adjustment in dosage

Sometimes a decrease in the dosage of Duloxetine can help manage such side effects. However, if you are on the lowest dose and the symptoms become unbearable then you should request an alternative medication from your healthcare provider.

Seeking medical advice

If you get persistent cold sensations and have tried all possible ways to make yourself comfortable, you should consult your doctor regarding your symptoms. Your healthcare provider will assess the situation and try to find out the underlying cause of your symptoms.

To the best of my knowledge, Duloxetine can cause chills or cold sensations in some individuals undergoing treatment. Not everyone taking Duloxetine experiences this side effect, and in some individuals, it subsides on its own. Medical intervention is hardly needed for this side effect.

Some tips and techniques are available to help you cope with your symptoms. However, if you consistently feel cold, and have shivers and cold sensations you should consult your healthcare provider regarding your symptoms and request a full workup to determine the underlying cause.

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The Food and Drug Administration (FDA). HIGHLIGHTS OF PRESCRIBING INFORMATION. CYMBALTA® (duloxetine hydrochloride) Delayed released capsules for oral use. Available from: 


Dhaliwal JS, Spurling BC, Molla M. Duloxetine. [Updated 2023 May 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


Wernicke JF, Gahimer J, Yalcin I, Wulster-Radcliffe M, Viktrup L. Safety and adverse event profile of duloxetine. Expert opinion on drug safety. 2005 Nov 1;4(6):987-93.

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