Does Duloxetine give you energy? (3+ tips)

In this article, we will answer the question “Does Duloxetine give you energy?”. We will also discuss research findings in this regard, what to do if Duloxetine does not help improve your energy and some self-care tips that can help you boost your energy levels while taking Duloxetine.

Does Duloxetine give you energy?

Duloxetine may give you energy and improve your mood. However, the improvement in energy levels is seen in individuals who respond positively to Duloxetine. The response to Duloxetine may vary in different individuals, and so will the ability of the medicine to improve your energy.

Duloxetine (also known as Cymbalta), is an antidepressant belonging to the class of serotonin and norepinephrine reuptake inhibitors (SNRIs) approved by the FDA for the treatment of major depressive disorder (MDD), generalised anxiety disorder (GAD), diabetic peripheral neuropathic pain (DPNP), fibromyalgia and chronic musculoskeletal pain (1).

Duloxetine increases the level of serotonin in the brain by inhibiting its reuptake. The high levels of serotonin are responsible for improved energy levels of the individual. Sometimes the increased energy becomes so intense that it causes the activation of manic episodes. During a manic episode, the individual can show extreme moods and behaviours (1).

Duloxetine is not an energy-boosting medication. It is an antidepressant that can improve energy levels in depressed patients. It can treat depression, but at the same time make you feel more energetic and motivated, like citalopram, venlafaxine or fluvoxamine.

What does research suggest?

Not many research studies have been published that analyse the effect of Duloxetine on energy levels. However, the very few that have been published report improved energy levels in depressed patients taking Duloxetine.

A study assessing the effects of Duloxetine when used for patients with chronic fatigue syndrome (CFS), reported that almost 51% of patients receiving Duloxetine showed improvement in energy levels while on the medication (2).

Another study analysing the effects of Duloxetine on the change in energy in patients with MDD concluded that Duloxetine can improve energy in depressed individuals as early as one week after starting therapy (3).

A study conducted in Japan, assessing the efficacy of Duloxetine and selective serotonin reuptake inhibitors (SSRIs) concluded that these medications have comparable efficacy but Duloxetine shows an advantage in improving energy and the loss of interest (4).

A clinical study comparing Sertraline and Duloxetine in the management of depressive illnesses stated that both these medications helped with the lack of energy experienced by patients. These medications improved the involvement of the individual in pleasurable activities (5).

What to do if Duloxetine does not boost your energy levels?

Duloxetine may cause some unwanted symptoms at the start of therapy. These side effects can include general fatigue, restlessness and agitation which tend to go away after your body adjusts to the medication.

After the first few weeks of therapy, you may start noticing improvements in energy and mood. However, if Duloxetine does not improve your symptoms or makes them worse you should consult your healthcare provider for guidance.

Your doctor will assess your situation, evaluate your symptoms and give you a plan according to your needs. Your healthcare provider may change the dose of Duloxetine or give you an alternative medication.

What are some self-care tips to improve energy while on Duloxetine?

Some self-care tips that can help you improve and optimize your energy levels while on Duloxetine include the following:

Regular exercise

Exercising regularly can keep you healthy as well as improve your mood. Exercise is found to produce endorphins which alter cortisol thereby improving mood and energy levels.

Improve diet and reduce caffeine and alcohol intake

Taking a healthy diet rich in minerals and vitamins can provide it with the nutrients and energy it needs. Alcohol and caffeine can also decrease energy levels. Although caffeine may give you energy, if consumed in large quantities during the day, it can also lead to insomnia. Alcohol reduces your concentration and makes you drowsy and fatigued thereby reducing energy.

Control stress and be well-rested

You should try to control stress and reduce stress-causing activities. Having a routine of meditation and yoga can also relieve stress and improve energy.

Low energy can also be due to inadequate sleep. Be sure to get as much sleep as your body needs. This is beneficial because getting enough sleep will improve your energy levels and your body will function better.

Keep yourself hydrated

Dehydration can cause fatigue and low energy levels. Taking enough water will help relieve these symptoms and increase energy levels.

Seeking professional guidance

You should talk to your healthcare provider about energy levels on Duloxetine. You should communicate any problems you experience while on Duloxetine therapy. Your doctor will assess your situation and advise you on the best techniques to improve your energy levels.

In my opinion, and according to research studies, Duloxetine may improve energy levels in individuals receiving treatment. However, this response may not be seen in all patients, as Duloxetine may not respond positively in everyone.

As individuals vary, so does their response to any given medication. So, it is advised to consult your healthcare provider if any symptoms of Duloxetine treatment cause discomfort or concern. You can also try some self-care tips to help improve your symptoms.

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The Food and Drug Administration (FDA). HIGHLIGHTS OF PRESCRIBING INFORMATION. CYMBALTA® (duloxetine hydrochloride) Delayed released capsules for oral use. Available from: 


Arnold LM, Blom TJ, Welge JA, Mariutto E, Heller A. A randomized, placebo-controlled, double-blinded trial of duloxetine in the treatment of general fatigue in patients with chronic fatigue syndrome. Psychosomatics. 2015 May 1;56(3):242-53.


Harada E, Kato M, Fujikoshi S, Wohlreich MM, Berggren L, Tokuoka H. Changes in energy during treatment of depression: an analysis of duloxetine in double‐blind placebo‐controlled trials. International Journal of Clinical Practice. 2015 Oct;69(10):1139-48.


Harada E, Schacht A, Koyama T, Marangell LB, Tsuji T, Escobar R. Efficacy comparison of duloxetine and SSRIs at doses approved in Japan. Neuropsychiatric Disease and Treatment. 2015 Jan 12:115-23.


Mowla A, Dastgheib SA, Razeghian Jahromi L. Comparing the effects of sertraline with duloxetine for depression severity and symptoms: a double-blind, randomized controlled trial. Clinical drug investigation. 2016 Jul;36:539-43.

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