Does duloxetine cause a runny nose? (+3 factors)

In this article, we will discuss whether duloxetine causes a runny nose. We will also discuss some factors that may increase the risk of a runny nose while taking duloxetine and the management tips for a runny nose. Additionally, we will discuss some common side effects of duloxetine.

Does duloxetine cause a runny nose?

No, duloxetine does not cause a runny nose. There is no established connection between the use of duloxetine and the occurrence of a runny nose. However, individual responses to medications can vary, and some individuals may experience unexpected side effects of duloxetine.

Duloxetine is an antidepressant medication that works by increasing the levels of serotonin and norepinephrine in the brain. The increased concentration of these neurotransmitters in the brain may help in the regulation of mood and behavior in individuals with underlying mental disorders. Duloxetine is frequently prescribed in the management of various health conditions such as depression, anxiety, and fibromyalgia (1).

Duloxetine is usually considered a well-tolerated medication with a lower incidence of serious side effects in individuals. However, it may cause some side effects in some susceptible patients.

What does research suggest?

There is no research evidence indicating a link between the use of duloxetine and the occurrence of a runny nose. A runny nose is not listed as a side effect of this medication.

Research suggests that duloxetine is a generally safe medication, and even at higher doses, it has a low incidence of side effects. Common side effects are typically mild to moderate and commonly include dizziness, nausea, vomiting, dry mouth, headache, and fatigue. Importantly, runny nose has never been reported as a side effect by patients taking duloxetine (2).

Factors increasing the risk of runny nose while taking duloxetine

A runny nose is not commonly associated with duloxetine use, but various factors unrelated to the medication could potentially contribute to this symptom. Some potential factors that may cause a runny nose while on duloxetine include (3,4):

Concurrent medications: Concurrent use of other medications could potentially contribute to a runny nose while taking duloxetine. These medications may include antihypertensive medications such as enalapril, lisinopril, and propranolol. Additionally, opioid analgesics, such as codeine or morphine, can sometimes lead to nasal congestion.

Underlying health conditions: Several pre-existing medical conditions can contribute to or increase the likelihood of a runny nose while taking duloxetine, such as a common cold, nasal polyps, and sinusitis. Conditions like allergic rhinitis or non-allergic rhinitis could contribute to nasal issues.

Environmental factors: Several environmental factors unrelated to duloxetine use can trigger nasal symptoms including a runny nose such as, changes in weather, especially cold or dry conditions, environmental irritants such as cigarette smoke and air pollution, and low humidity levels. 

It’s essential to consult with a healthcare professional if you experience persistent or bothersome symptoms while taking duloxetine or any other medication. They can help identify the underlying cause and determine the appropriate course of action.

How to manage a runny nose while taking duloxetine?

Experiencing a runny nose while taking duloxetine is generally a self-limiting condition and does not typically interfere with the medication’s effectiveness. In most instances, the symptom may resolve on its own without the need for additional interventions.

However, if the runny nose persists or becomes bothersome, it is recommended to consult with your healthcare provider. They can provide guidance on whether the runny nose is related to duloxetine or if other factors may be contributing to it.

If allergies are suspected, your healthcare provider might recommend antihistamines or other allergy medications to alleviate symptoms. Additionally, over-the-counter nose drops could be recommended as they may provide relief by moisturizing and soothing the nasal passages.

These measures aim to address potential allergic triggers and improve your overall comfort during the management of nasal symptoms.

What side effects are associated with the use of duloxetine?

While duloxetine does not cause a runny nose, there are some other potential side effects of duloxetine that may occur frequently in individuals taking this medication. These side effects may include:

  • nausea
  • vomiting 
  • dizziness
  • headaches
  • fatigue
  • drowsiness
  • electrolyte disturbances 
  • loss of appetite
  • weight loss
  • cardiovascular complications
  • sleep disturbances
  • dry mouth

It’s crucial to discuss any side effects with your healthcare provider, as they can provide guidance on managing symptoms or consider adjustments to the treatment plan if necessary. Additionally, some side effects may diminish over time as your body adjusts to the medication. Always consult with a healthcare professional for personalized advice and monitoring during duloxetine therapy.

 In my opinion, while duloxetine therapy may have certain side effects like nausea, dry mouth, and dizziness, it’s important to note that antidepressants, including duloxetine, are generally not known for causing a runny nose.

However, individual responses can vary, and any concerns about side effects should be discussed with your healthcare provider for personalized guidance and adjustments to your treatment plan if necessary.

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Dhaliwal JS, Spurling BC, Molla M. Duloxetine. 2023 May 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31747213.


Cowen PJ, Ogilvie AD, Gama J. Efficacy, safety and tolerability of duloxetine 60 mg once daily in major depression. Curr Med Res Opin. 2005 Mar;21(3):345-56. doi: 10.1185/030079905X30680. PMID: 15811202.


Bergsmark J, Gadeholt G. Nesepolypper og kronisk sinusitt som mulig bivirkning av uselektive betablokkere [Nasal polyps and chronic sinusitis as a possible adverse effect of non-selective beta blockers]. Tidsskr Nor Laegeforen. 1994 Aug 10;114(18):2116-7. Norwegian. PMID: 7992269.


Daley CL, Sande M. The runny nose. Infection of the paranasal sinuses. Infect Dis Clin North Am. 1988 Mar;2(1):131-47. PMID: 3074104.

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