Does Celexa contain an antihistamine? (+5 differences)

 In this article, we will discuss whether Celexa contains an antihistamine. Additionally, we will delve into the composition of Celexa’s formulation, highlighting the key differences between Celexa and antihistamine medications. This discussion will encompass their mechanisms, side effects, and uses, providing a comprehensive understanding of their distinctions.

Does Celexa contain an antihistamine?

No, Celexa does not contain an antihistamine. It is an antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) class. It is not designed or intended to have the properties of an antihistamine.

Antihistamines are specifically designed to block the action of histamine and are commonly used for treating allergy symptoms, while Celexa is an antidepressant that modulates serotonin levels in the brain (1,2). These medications have different purposes, and their formulations include distinct active ingredients. 

What are the ingredients of Celexa formulation?

The formulation of Celexa contains both active and inactive ingredients, also known as excipients. The specific inactive ingredients in Celexa can vary depending on the manufacturer and the form of the medication, whether it’s in tablets or oral solution.

Active ingredient Citalopram hydrobromide
Excipients  Binders, fillers, disintegrants, coloring agents, preservatives, flavoring agents, coating agents, lubricants, solubilizers, humectants, and antiadherents.

What are antihistamines and their functions?

Antihistamines are employed in the treatment of allergic reactions, addressing symptoms such as itching, sneezing, watery eyes, and a runny nose. They operate by blocking the effects of histamine, a chemical in our body responsible for allergic reactions. These medications are frequently prescribed to manage conditions such as:

  • Allergy relief
  • Hives and rash treatment
  • Nasal congestion
  • Motion sickness
  • Insomnia

What are the key differences between Celexa and antihistamines?

The key differences between Celexa and medications belonging to the class of antihistamines may include their(1,2):

Features Celexa antihistamines
Class selective serotonin reuptake inhibitor (SSRI) first-generation (sedating) and second-generation (non-sedating).
Mechanism of action Inhibits the reuptake of serotonin, enhancing serotonin levels and regulating mood. Blocks histamine receptors, alleviating allergy symptoms
Indications Treatment of depression, panic disorder, and certain anxiety disorders Relieves symptoms of allergic reactions, such as sneezing, itching, and runny nose
Side Effects nausea, dry mouth, insomnia, loss of appetite, and sexual dysfunction.  drowsiness, dry mouth, and blurred vision 
Formulation (dosage forms)

tablets or oral solution

 

tablets, capsules, liquids, and nasal sprays. 

Does Celexa show any potential interactions with antihistamines?

Yes, there is a potential interaction between Celexa and some antihistamines. Combining these medications may heighten the risk of experiencing their common side effects, leading to additional effects such as sedation, drowsiness, and dizziness (1,2).

Moreover, both Celexa and antihistamines can contribute to lowering blood pressure, and their combination may result in feelings of dizziness or lightheadedness, particularly when standing up (3,4).

If you need to combine Celexa with an antihistamine, it is advisable to opt for a nonsedative variant such as cetirizine, loratadine, or fexofenadine. Choosing a nonsedative antihistamine can help mitigate the risk of feeling excessively sleepy when combined with Celexa.

Consult with your doctor to determine which nonsedative antihistamine is suitable for your needs. Moreover, whenever possible, consider taking Celexa and antihistamines at different times of the day. Creating a time gap between the doses of these two medications can help prevent potential interactions, likely reducing the severity of side effects.

Always follow your healthcare provider’s guidance regarding the appropriate timing and dosage to ensure the safe and effective use of these medications.

In my experience

In my experience, the formulations of citalopram, such as Celexa, do not include any antihistamines. Celexa is a frequently prescribed medication in clinical settings for managing various mental disorders, like depression and anxiety. There is no established connection or inclusion of antihistamine medications in Celexa’s composition or intended use.

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References

1.-

Sharbaf Shoar N, Fariba KA, Padhy RK. Citalopram. [Updated 2023 Nov 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482222/

2.-

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Antihistamines. 2017 Jan 16. PMID: 31643232. https://pubmed.ncbi.nlm.nih.gov/31643232/

3.-

Ozdemir PG, Karadag AS, Selvi Y, Boysan M, Bilgili SG, Aydin A, Onder S. Assessment of the effects of antihistamine drugs on mood, sleep quality, sleepiness, and dream anxiety. Int J Psychiatry Clin Pract. 2014 Aug;18(3):161-8. doi: 10.3109/13651501.2014.907919. Epub 2014 Apr 23. PMID: 24673474. Available from: https://pubmed.ncbi.nlm.nih.gov/24673474/

4.-

National Collaborating Centre for Mental Health (UK). Depression in Adults with a Chronic Physical Health Problem: Treatment and Management. Leicester (UK): British Psychological Society (UK); 2010. (NICE Clinical Guidelines, No. 91.) Appendix 16, Table of drug interactions. Available from: https://www.ncbi.nlm.nih.gov/books/NBK82914/

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