Does Buspirone cause sweating? (3+ risk factors)

In this article, we will discuss Buspirone-induced sweating. We will also discuss some factors that may put some people at a higher risk of this side, as compared to others. We will also discuss what one should do if this side effect occurs.

Does Buspirone cause sweating?

Buspirone may cause sweating in some individuals. It is listed as a rare or uncommon side effect of Buspirone and not many cases have been reported so far (1).

Buspirone is a medication used to treat anxiety, and it controls excessive sweating and palpitations associated with anxiousness (2). However, it’s important to remember that the occurrence of side effects like sweating does not mean the medication is unsafe or ineffective.

It’s a matter of how your body reacts to the medication. If your sweating persists or starts affecting the quality of your life, please reach out to your healthcare provider. 

What does research suggest?

There is limited research on sweating induced by Buspirone. One research study indicated that only 1% of the people taking Buspirone have reported this side effect (3). The exact mechanism through which Buspirone may cause sweating is not fully understood.

However, research suggests that Buspirone affects certain chemicals in the brain, especially serotonin and dopamine (2). Serotonin, in particular, is involved in many bodily functions, including temperature regulation (4).

When the medication affects serotonin levels, it might result in your body feeling warmer than usual, and as a response, you might start sweating to cool down (4).

This is one of the main reasons why serotonin-specific antidepressants, like Lexapro (Escitalopram), can also cause sweating as a side effect (5). However, it is important to note that not everyone will experience this side effect while taking Buspirone.

People who do experience this usually start to get better as their bodies adjust to the medication. 

What are the risk factors for Buspirone-induced sweating?

There are some risk factors for Buspirone-induced sweating. These include: 

  • Dosage strength – people at higher doses are at a higher risk of side effects.
  • Individual response to the drug – people can react differently to medications.
  • Concomitant use of other medications – Buspirone can be paired with other medications, like antidepressants, which may increase the risk of excessive sweating. 
  • Underlying health conditions – some people may experience increased sweating because of an underlying health condition.
  • Environmental factors – people living in hot and humid weather are more likely to sweat while taking Buspirone, as compared to people living in colder weather. 

Remember, sweating on Buspirone is not that common and these factors might increase the risk of getting this side effect. 

What to do if Buspirone causes sweating as a side effect?

It is important to consult your doctor if Buspirone causes excessive sweating. Your doctor might consider lowering the dosage of Buspirone to see if that reduces the sweating while still effectively managing your symptoms.

Changing the timing of taking Buspirone may also help sometimes. In most cases, the side effect begins to fade away on its own as the body adjusts to the effects of Buspirone.

However, in some cases, the side effect may persist and your doctor may prescribe another medication to control sweating or safely switch you to another anti-anxiety medication. Just make sure you don’t stop taking Buspirone without your doctor’s approval.

Medications like Buspirone are tapered off and they should never be discontinued abruptly. Doing so can subject you to disturbing withdrawal symptoms. This is why always reach out to your doctor to discuss your concerns.


In this article, we have discussed Buspirone-induced sweating. We have also discussed the possible mechanism through which this med can trigger sweating and what one should do if this side effect occurs. 

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National Library of Medicine. Buspirone: MedlinePlus Drug Information [Internet]. Bethesda (MD): U.S. National Library of Medicine. Available from:


Wilson TK, Tripp J. Buspirone. 2023 Jan 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30285372. Available from:


Newton RE, Marunycz JD, Alderdice MT, Napoliello MJ. Review of the side-effect profile of buspirone. Am J Med. 1986 Mar 31;80(3B):17-21. doi: 10.1016/0002-9343(86)90327-x. PMID: 2870641. Available from:


Kanova M, Kohout P. Serotonin-Its Synthesis and Roles in the Healthy and the Critically Ill. Int J Mol Sci. 2021 May 3;22(9):4837. doi: 10.3390/ijms22094837. PMID: 34063611; PMCID: PMC8124334. Available from:


Marcy TR, Britton ML. Antidepressant-induced sweating. Ann Pharmacother. 2005 Apr;39(4):748-52. doi: 10.1345/aph.1E564. Epub 2005 Feb 22. PMID: 15728327. Available from: