Does Benadryl cause nosebleeds? (3 helpful tips)

In this article, we will discuss nosebleeds associated with the use of Benadryl, an antihistamine. We will also discuss the mechanism of Benadryl-induced nosebleeds and what one should do if this side effect occurs.

Does Benadryl cause nosebleeds?

Benadryl (Diphenhydramine) may cause nosebleeds in some individuals. Although it is not a common side effect and is not something one should be concerned about when taking Benadryl, a few cases of Benadryl-induced nosebleeds have been reported (1).

However, it is important to note that people are different and they can respond to medications differently. If you are someone who experiences nosebleeds while taking Benadryl, you should discuss it with your healthcare provider.

What does research suggest?

There is limited research on nosebleeds associated with Benadryl and there are only a few reported cases. However, research does indicate that the possible mechanism behind Benadryl-induced nosebleeds involves its anticholinergic properties (1).

It is also indicated that people who use Benadryl for a long time, like using it as a sleep aid, can be more susceptible to such anticholinergic side effects (2). Nosebleeds may also occur in case of overdosing on Benadryl or Benadryl toxicity (3). In such cases, seeking immediate medical attention is crucial.

How can Benadryl cause nosebleeds?

As stated in the previous section, Benadryl can cause nosebleeds because of its anticholinergic properties. It can dry out mucous membranes, including those in the nasal passages (1). This drying effect can lead to irritation and increased fragility of the blood vessels in the nose, making them more prone to bleeding.

Interestingly, this drying effect is the main reason why some people take Benadryl when they have a runny nose. So, while this drying effect can be desired by some people, sometimes it goes a bit too far – leading to irritation of the nasal blood vessels.

What to do if Benadryl causes nosebleeds?

If you struggle with Benadryl-induced nosebleeds, there are three things that can help:

Discussion with your doctor

The best way to be certain that Bendaryl is not affecting your health is to discuss your concerns with your doctor. Your provider will properly determine the exact cause of your symptoms and come up with the best management strategy. Your doctor may also rule out the other potential causes of nosebleeds, which may include: (4)

• Low humidity in the environment
• Nasal trauma or injury
• Untreated nasal allergy
• Nasal polyps
• Haematological disorders
• Infections

It is also important to discuss sleep disturbances with your doctor if you are taking Benadryl to help you sleep. Benadryl is a fast-acting sleep aid and can start to make you drowsy within an hour. However, it is not a permanent solution for your insomnia and taking it for a long time can make you more susceptible to side effects like nosebleeds.

Using other antihistamines

If Benadryl makes your nose bleed, there are other OTC antihistamines that may help. Research suggests that some second-generation antihistamines, including Allegra (Fexofenadine) and Zyrtec (Cetirizine), do not possess anticholinergic activities that other antihistamines do (5).

This indicates that using an antihistamine with a low potential for anticholinergic effects carries a lower risk of nosebleeds.

Trying home remedies

If your symptoms are mild, you can try home remedies to help you with a runny nose and alleviate nasal dryness. Some common remedies include:

• Saline nasal sprays
• Inhaling steam
• Using a humidifiers
• Drinking lemon and honey water
• Sipping some ginger tea
• Avoiding irritants

What are the additional anticholinergic side effects of Benadryl?

Benadryl can also cause some additional anticholinergic side effects, including (6):

• Dry mouth
• Dry eyes
• Constipation
• Dry skin
• Mydriasis (Dilated pupils)

If you’re experiencing any such side effects while taking Benadryl, talk to your doctor or pharmacist. Medications like Benadryl are not meant to be used for a long time.

If you’re struggling with insomnia or recurrent allergies, please talk to your doctor to discuss alternative options or lifestyle modifications that could help. Remember, safe and effective use of medications is the most important key to achieving your desired therapeutic outcomes.

Conclusion

In this article, we have discussed nosebleeds associated with Benadryl. We have also discussed some helpful steps that can you take if you’re struggling with this side effect or any other anticholinergic side effect associated with Benadryl.

References