Does Benadryl cause atrial fibrillation? (+5 factors)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss whether Benadryl can cause atrial fibrillation. We will also discuss the research linking Benadryl and atrial fibrillation and the factors that may increase the risk of atrial fibrillation while taking Benadryl. Additionally, we will discuss the management of Benadryl-induced partial fibrillation.
Does Benadryl cause atrial fibrillation?
Benadryl does not cause atrial fibrillation. However, it may cause other cardiovascular complications such as QT prolongation, palpitations, tachycardia, and arrhythmias but it is not associated with atrial fibrillation.
Benadryl (diphenhydramine), is an antihistamine medication. It is frequently indicated in the management of common colds, hay fever, allergic rhinitis, and seasonal allergies. Due to its anticholinergic properties, it has some sedative effects that can be utilized in the management of sleep disturbances. The side effects of Benadryl may include dizziness, drowsiness, gastrointestinal distress, confusion, allergic reactions, tardive dyskinesia, and palpitations (1).
On the other hand, atrial fibrillation is a cardiovascular condition characterized by rapid and irregular heart rhythms. The risk of atrial fibrillation is higher in patients with chronic hypertension and other cardiovascular diseases (4). Benadryl can cause different heart conditions including arrhythmias in some individuals but atrial fibrillation is not reported yet with the use of Benadryl.
What does research suggest?
According to research, due to the anticholinergic properties of Benadryl, it may develop cardiovascular complications in some individuals.
A case study reported that an infant who was prescribed IV Benadryl for sedation, experienced cardiac arrest after taking the medication. This incident indicated the potential risk of cardiovascular complications associated with the use of Benadryl, especially in infants (2).
Additionally, research suggests that Benadryl is associated with developing severe arrhythmias and QT interval prolongation. It may also block the k channels in the heart leading to various cardiovascular complications. However, it is important to note that, while Benadryl may lead to CVS complications, there is no evidence linking it to atrial fibrillation (3).
What factors can contribute to atrial fibrillation while taking Benadryl?
Presence of certain factors can contribute to the risk of developing atrial fibrillation while taking Benadryl such as:
Pre-existing medical conditions: The risk of developing cardiovascular complications including arterial fibrillation is higher in patients having pre-existing medical conditions such as high blood pressure (hypertension), a history of myocardial infection, heart valve disorders, heart failure, kidney diseases, and obesity.
Use of alcohol: Alcohol can directly affect the heart’s electrical conduction system. Chronic alcohol consumption may increase the risk of partial fibrillation in individuals taking Benadryl.
Biological factors: These factors may include the age and gender of the patients. The prevalence of atrial fibrillation is higher among elderly men. Aging can lead to changes in the heart’s structure and function, contributing to the development of atrial fibrillation.
Genetic factors: The risk of atrial fibrillation may be higher if there’s a family history of atrial fibrillation. Genetic factors may play an important role in predisposing certain individuals to atrial fibrillation.
Medications: The concomitant use of Benadryl with other medications such as paclitaxel, milrenone, theophylline, and adenosine, which are known for their potential to induce atrial fibrillation as a side effect, can enhance specific side effects of Benadryl, potentially increasing the likelihood of arrhythmias and the associated risk of developing atrial fibrillation (5).
What are the common symptoms of atrial fibrillation?
The symptoms of atrial fibrillation may include, irregular heartbeats, pain in the chest, fatigue, lightheadedness, confusion, tachycardia, and difficulty breathing (4).
It’s important to note that some individuals with atrial fibrillation may not experience noticeable symptoms, and the condition may be detected during routine medical examinations or screenings. If someone suspects they have symptoms of atrial fibrillation, it’s essential to consult with a healthcare professional for proper evaluation and management.
How do you manage atrial fibrillation while taking Benadryl?
If you experience any symptoms of atrial fibrillation while taking Benadryl, consult your healthcare provider. If Benadryl is causing or exacerbating the symptoms of atrial fibrillation, your healthcare provider may adjust the dosage or provide you with an alternative to Benadryl to ensure a safe and effective therapy with fewer side effects.
Your doctor may prescribe you medications for the management of atrial fibrillation such as amiodarone, diltiazem, and propranolol. However, you should never start any medication without consulting your healthcare provider.
Lifestyle changes including a healthy diet, sufficient water intake, adequate rest and sleep, as well as other stress management techniques including regular exercises, yoga, and meditation can help manage stress which may contribute to triggering atrial fibrillation episodes.
In my experience as a pharmacist, I have rarely encountered patients in clinical settings complaining of severe cardiovascular complications with Benadryl. To my knowledge, this medication may cause a few side effects, including palpitations, arrhythmias, and tachycardia, which may overlap with symptoms of atrial fibrillation. However, it is essential to consult with your healthcare provider, they will assess your overall condition and provide you with a suitable treatment plan.
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References
1.-
Huynh DA, Abbas M, Dabaja A. Diphenhydramine Toxicity. 2023 Apr 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32491510. https://pubmed.ncbi.nlm.nih.gov/32491510/
2.-
Andersen CL, Tobias JD. Cardiac Arrest Following the Administration of Intravenous Diphenhydramine for Sedation to an Infant With Congenital Heart Disease. J Pediatr Pharmacol Ther. 2021;26(3):311-314. doi: 10.5863/1551-6776-26.3.311. Epub 2021 Mar 31. PMID: 33833635; PMCID: PMC8021246. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021246/
3.-
Huynh DA, Abbas M, Dabaja A. Diphenhydramine Toxicity. [Updated 2023 Apr 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557578/
4.-
Nesheiwat Z, Goyal A, Jagtap M. Atrial Fibrillation. 2023 Apr 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30252328. https://pubmed.ncbi.nlm.nih.gov/30252328/
5.-
Kaakeh Y, Overholser BR, Lopshire JC, Tisdale JE. Drug-induced atrial fibrillation. Drugs. 2012 Aug 20;72(12):1617-30. doi: 10.2165/11633140-000000000-00000. PMID: 22834678; PMCID: PMC5531271. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531271/
