Can you use Pantoprazole and Coffee together? (3 risks)
By
Dr Natalia Marceli Stephanes (PhD)
Author bio
Dr Natália Marcéli Stephanes PhD is a Pharmacist with expertise in Drugs Administration and Toxicity; Discovery of New Drugs; Cancer Treatment; Biochemical Analyzes and Hematological Analyzes. She writes and reviews content on these topics.
Dr Natália Marcéli Stephanes’ Highlights:
- Pharmacist at the Department of Health of Santa Catarina State, Brazil
- PhD with a focus on oncology treatment
- Years of experience in commercial pharmacy
- Bachelor, Master and PhD degrees in Pharmacy at the Federal University of Santa Catarina
Professional Experience:
From her undergraduate studies to her Master’s and Doctorate degrees in Pharmacy, Dr Natália Marcéli Stephanes has participated in numerous scientific studies in the field of oncology and onco-hematology at the University Hospital of the Federal University of Santa Catarina, Brazil. Her research has focused on understanding the molecular and biochemical bases of malignant neoplasms and investigating safer and more effective therapeutic alternatives.
Dr Natália Marcéli Stephanes has also served as an assistant professor of haematology for undergraduate students at the Federal University of Santa Catarina. Additionally, she held the position of professor of Hospital Pharmacy at the Qualificar Technical School in Brazil, where she developed instructional materials for use in the Pharmacy Postgraduate Program at the Leonardo Da Vinci University Center.
In addition to her academic experiences, Dr Natália Marcéli Stephanes possesses a strong expertise in commercial pharmacy, with in-depth knowledge of medications, their routes of administration, desired effects, adverse effects, and toxicity.
Currently, Dr Natália Marcéli Stephanes works as a Pharmacist at the Health Department of Santa Catarina State, where her role entails providing pharmaceutical scientific consulting services to judges.
Education:
- 2016 Bachelor in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2018 Master in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2023 PhD in Pharmacy at the Federal University of Santa Catarina, Brazil
The main publications of Dr Natália Marcéli Stephanes are:
Falchetti M ; Delgobo M, Zancanaro H, Almeida K, Das Neves RN, Dos Santos B, Stefanes NM, et al. Bishop Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Comput. Biol. Med [Internet]. 2023; 152:106347.
Feuser PM, Matos dos Santos PC, Cordeiro AP, Stefanes NM, Walter LO, Maioral MF, Santos-Silva MC, et al. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562). J Drug Deliv Sci Technol [Internet]. 2022; 67:102924.
Jacques AV, Stefanes NM, Walter LO, Perondi DM, Efe FL, Souza LFS, Sens L, et al. Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines. Bioorg. Chem [Internet]. 2021; 116:105315.
Duarte BF, Vieira DSC, Lisboa ML, Stefanes NM, Grando LJ, Santos-Silva MC. Características clínico-epidemiológicas de pacientes portadores de carcinoma de células escamosas de boca. Arquivos Catarinenses de Medicina. 2021; 50(2): 232–245.
Machado V, Jacques AV, Stefanes NM, Santos-Silva MC, Biavatti MW. Anti-leukemic activity of semisynthetic derivatives of Lupeol. Nat. Prod. Res. 2021; 35(22):4494-4501.
Bigolin A, Maioral MF, Stefanes NM, Mascarello A, Chiaradia-Delatorre LD, Nunes RJ, Yunes RA, et al. A novel sulfonamide derivative as a strong and selective apoptotic agent against hematological malignancies. Chem. Pap. 2020; 74:2965–2976.
Bigolin A, Maioral MF, Stefanes NM, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anticancer Drugs. 2020; 31(7):709-717.
Maioral MF, Stefanes NM, Neufeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC. Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med. Chem. 2020; 12(8):673–688.
Perondi DM, Jacques AV, Stefanes NM, Maioral MF, Sens L, Pacheco LA, Cury NM, et al. A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. Anticancer Drugs. 2019; 30(8):p 828-837.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Argenta DF, Dotto MER, Santos-Silva MC, et al. PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment. Eur. Polym. J. 2019; 119:335-343.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Santos-Silva MC, Nunes RJ, Parize AL, et al. A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity. Mater. Sci. Eng. C [Internet]. 2019; 105:110051.
Maioral MF, Stefanes NM, Bigolin A, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Miconidine acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest. New Drugs. 2019; 37:912–922.
Srefanes NM, Toigo J, Maioral MF, Jacques AV, Chiaradia-Delatorre LD, Perondi DM, Ribeiro AAB, et al. Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity. Bioorg. Med. Chem. 2019; 27(2):375-382.
Maioral MF, Bodack CN, Stefanes NM, Bigolin A, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochim. 2017; 140:48-57.
You can view some of Dr Natália’s work below and links to her professional profile below.
Research Gate: https://www.researchgate.net/profile/Natalia-Stephanes
Linkedin: https://www.linkedin.com/in/nataliamarceli/
In this blog post, we are going to answer the question, “Can you use Pantoprazole and Coffee together?”. Pantoprazole is a commonly used Proton pump inhibitor which can help counteract the symptoms associated with gastric acid reflux and heartburn.
However, this medicine may not pair well with the most commonly used beverage; coffee. This blog will cover the safety and efficacy of the concomitant use of Pantoprazole and Coffee.
Can you use Pantoprazole and Coffee together?
No, it is not recommended to take Pantoprazole and Coffee together. The combination of these two may make your symptoms worse, either by exacerbating your condition or by decreasing the efficiency of Pantoprazole. You can drink coffee after 30 minutes to an hour of taking Pantoprazole.
Pantoprazole is a Proton pump inhibitor. The last and very basic step in the production of gastric acid in your stomach is the binding of H+ ions to Cl- ions. This combination completes the molecular formula of Hydrochloric acid (HCl), which is the type of acid our body makes.
Pantoprazole and other PPIs block this last stage by blocking the pump which supplies these H+ ions. When there are no free hydrogen ions (protons) available to bind with the chloride ions, acid production is hindered.
This is how these meds control your acid reflux, heartburn, and related symptoms. PPIs are considered safe to use and almost everyone responds well to them. They can be considered over-the-counter meds and you may not need a doctor’s prescription to take this med.
If we look at the topic of our discussion closely, we can see that both Pantoprazole and Coffee can be used together without your doctor even knowing about this. If you continue to take large amounts of these two together, you may be subjected to a number of serious complications.
Coffee, on the other hand, acts as a central nervous system (CNS) stimulant. It has an active ingredient caffeine which actually increases your mental alertness and energy levels. Caffeine is also believed to boost your metabolism.
It can help some people lose weight because of that very effect. Coffee can also increase gastrointestinal motility in some people and help regulate their bowel movements. Coffee can also act as a diuretic.
This is why experts suggest drinking plenty of water if you’re a regular coffee drinker to prevent any possible symptoms associated with dehydration. Because of this diuretic effect, coffee can decrease your blood volume and it may decrease your blood pressure.
This is why you should not drink too much coffee as an excess of this beverage can result in a number of difficulties. It can also cause anxiety at higher doses.
What are the risks associated with the concomitant use of Pantoprazole and Coffee?
The most common risks associated with the concomitant use of Pantoprazole and Coffee include:
- Inefficiency of Pantoprazole
- Exacerbation of your gastric disease
- Risk of caffeine overuse
Inefficiency of Pantoprazole
The concomitant use of Pantoprazole and Coffee may result in some type of pharmacokinetic interaction that can decrease the efficacy of this Proton pump inhibitor. When the drug fails to do what it is supposed to, you do not find enough relief in your condition.
This can result in therapeutic failure. This is why it is not recommended to pair acid reducers with any such thing. Taking them on an empty stomach or half an hour to an hour before breakfast can result in more pronounced effects of the drug.
Exacerbation of your gastric disease
Drinking coffee with Pantoprazole can exacerbate your gastric disease. This is because coffee has a strong impact on your gastrointestinal system. It not only increases intestinal motility, but it can also make your acidity worse.
This is why you may see some healthcare providers who generally ask you to cut back on alcohol when you’re suffering from an upset stomach.
This condition may not become a big problem if you suffer from minor or seasonal acid reflux, but it can give rise to a number of complications if you have an ulcer, either gastric or duodenal.
An ulcer is an entire disease which occurs as a result of the damage caused by stomach acid. When acidity increases over time, it starts to damage your protective gastric mucosa bit by bit. It may cause a burning sensation and abdominal pain at first, but it gets much worse.
With time, this acid completely destroys the protective barrier on the lining of your stomach which starts to bleed. It becomes a wound, an ulcer, which continues to ache and bleed. This condition can get significantly affected by the use of caffeine and it should be completely stopped.
Risk of caffeine overuse
Several studies have indicated that Pantoprazole may decrease the effects of coffee. It may act on your stomach, but the CNS stimulatory effects of caffeine may become less prominent. This can lead to the misuse or overuse of caffeine.
This is because people who are addicted to coffee first thing in the morning may not feel that kick or that head start of their day. This will make them come back for another cup of coffee and then another. Excessive intake of coffee is an entire problem on its own.
Coffee can cause anxiety and several other mood-related problems when it is consumed in excess. Several research studies have indicated that coffee can increase intestinal motility. To confirm this claim, a double-blind placebo trial was performed in which the test participants were divided into two groups.
All of the people included in the study were suffering from mild to moderate constipation. It was important because the study aimed to see the effects of caffeine on constipation.
After the study, it was observed that the group that received coffee showed more frequent bowel movements as compared to the placebo group. This study indicated that caffeine does increase intestinal motility and it helps some people regulate their bowel movements.
This means that excessive coffee will not only make your stomach hurt by increasing your acid reflux, but it can also cause diarrhoea. So, it is important to take Pantoprazole properly to make out of it. Make sure to check for the expiry date before you take your meds.
Expired medications won’t help you with your symptoms adequately.
What are the side effects associated with the use of Pantoprazole and Coffee?
Both Pantoprazole and Coffee are associated with some side effects. These side effects may become more prominent if you’re taking both of these together. However, these side effects can vary from person to person.
Some people can tolerate the two chemicals well and they won’t feel that much of a difference in their health, as compared to some other people who might get affected pretty badly. Let’s look at the side effects of Pantoprazole and Coffee individually.
Side effects of Pantoprazole
Pantoprazole is associated with the following side effects:
- Nausea
- Vomiting
- Diarrhoea
- Flatulence
- Bloating
- Headache
- Dizziness
- Joint pain
- Muscle pain
- Upset stomach
Pantoprazole can also cause some rare and serious side effects which may require immediate medical attention. Make sure you reach out to your healthcare provider as soon as you can if you suffer from the following side effects:
- An allergic reaction
- Redness of skin
- Itching
- Burning sensation
- Blue-purple patches
- Tightness of chest
- Wheezing
- Hoarseness
- Inability to breathe
- Swelling or tenderness in different parts of the body
- Irregular heartbeat or arrhythmia
- Severe diarrhoea that may lead to hospitalisation
- Muscle twitching and weakness
- Cough
- Severe diarrhoea
- Confusion
- Forgetfulness
Side effects of coffee
Coffee is associated with the following side effects:
- Anxiety
- Sleep disturbance or insomnia. It also decreases sleep quality
- Headaches
- Dizziness
- Tachycardia
- Dehydration, as it causes diuresis
- Muscle pain
- Addiction
- Fatigue
- Tolerance
- Gastrointestinal issues like nausea, vomiting, diarrhoea etc.
Some people may not stand coffee at all. It is either because of the bitter taste of the beverage, or an allergic reaction to it. Make sure you consult your healthcare provider if you’re a heavy coffee drinker and you’re just about to start taking a new medication, whether a prescription medication or an OTC one.
Conclusion
In this blog post, we have discussed the concomitant use of Pantoprazole and Coffee. The combination of these two may make your symptoms worse, either by exacerbating your condition or by decreasing the efficiency of Pantoprazole.
You can drink coffee after 30 minutes to an hour of taking Pantoprazole. Make sure you talk to your healthcare provider for further information and talk about the proper use of these meds.
FAQs: pantoprazole and coffee
What should you not take with pantoprazole?
Pantoprazole should not be taken with any medication that may contain rilpivirine in it. The concomitant use of these two can give rise to a number of complications. Pantoprazole is a Proton pump inhibitor. cause some rare and serious side effects which may require immediate medical attention. Make sure you reach out to your healthcare provider as soon as you can if you exhibit any sign of an allergic reaction or any unusual side effect after taking your first-ever dose of Pantoprazole.
Does pantoprazole need to be taken on an empty stomach?
Pantoprazole works best when it is taken on an empty stomach, most commonly half an hour to an hour before breakfast. Pantoprazole is a Proton pump inhibitor. The last and the very basic step in the production of gastric acid in your stomach is the binding of H+ ions to Cl- ions. This combination completes the molecular formula of Hydrochloric acid (HCl), which is the type of acid our body makes. Pantoprazole and other PPIs block this last stage by blocking the pump which supplies these H+ ions.
Can you use Pantoprazole and Coffee together?
No, it is not recommended to take Pantoprazole and Coffee together. The combination of these two may make your symptoms worse, either by exacerbating your condition or by decreasing the efficiency of Pantoprazole. You can drink coffee after 30 minutes to an hour of taking Pantoprazole. The concomitant use of Pantoprazole and Coffee may result in some type of pharmacokinetic interaction that can decrease the efficacy of this Proton pump inhibitor. When the drug fails to do what it is supposed to, you do not find enough relief in your condition.
What are the side effects of Pantoprazole?
Pantoprazole is associated with the following side effects:
- Nausea
- Vomiting
- Diarrhoea
- Flatulence
- Bloating
- Headache
- Dizziness
- Joint pain
- Muscle pain
- Upset stomach
Can Pantoprazole be dangerous?
Pantoprazole can also cause some rare and serious side effects which may require immediate medical attention. Make sure you reach out to your healthcare provider as soon as you can if you suffer from the following side effects:
- An allergic reaction
- Redness of skin
- Itching
- Burning sensation
- Blue-purple patches
- Tightness of chest
- Wheezing
- Hoarseness
- Inability to breathe
- Swelling or tenderness in different parts of the body
- Irregular heartbeat or arrhythmia
- Severe diarrhoea that may lead to hospitalisation
- Muscle twitching and weakness
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References
1.-
NHS – Pantoprazole https://www.nhs.uk/medicines/pantoprazole/#:~:text=You%20can%20eat%20and%20drink,cola%2C%20as%20well%20as%20alcohol.
2.-
Pantoprazole Interactions with Drugs, Food & Conditions https://druggenius.com/interactions/pantoprazole/
3.-
Pantoprazole And Caffeine: What You Need To Know https://www.trung-nguyen-online.com/can-you-drink-coffee-while-taking-pantoprazole/
4.-
National Library of Medicine – Pantoprazole https://medlineplus.gov/druginfo/meds/a601246.html
