Can you take Pantoprazole in the morning and Omeprazole at night?
By
Dr Natalia Marceli Stephanes (PhD)
Author bio
Dr Natália Marcéli Stephanes PhD is a Pharmacist with expertise in Drugs Administration and Toxicity; Discovery of New Drugs; Cancer Treatment; Biochemical Analyzes and Hematological Analyzes. She writes and reviews content on these topics.
Dr Natália Marcéli Stephanes’ Highlights:
- Pharmacist at the Department of Health of Santa Catarina State, Brazil
- PhD with a focus on oncology treatment
- Years of experience in commercial pharmacy
- Bachelor, Master and PhD degrees in Pharmacy at the Federal University of Santa Catarina
Professional Experience:
From her undergraduate studies to her Master’s and Doctorate degrees in Pharmacy, Dr Natália Marcéli Stephanes has participated in numerous scientific studies in the field of oncology and onco-hematology at the University Hospital of the Federal University of Santa Catarina, Brazil. Her research has focused on understanding the molecular and biochemical bases of malignant neoplasms and investigating safer and more effective therapeutic alternatives.
Dr Natália Marcéli Stephanes has also served as an assistant professor of haematology for undergraduate students at the Federal University of Santa Catarina. Additionally, she held the position of professor of Hospital Pharmacy at the Qualificar Technical School in Brazil, where she developed instructional materials for use in the Pharmacy Postgraduate Program at the Leonardo Da Vinci University Center.
In addition to her academic experiences, Dr Natália Marcéli Stephanes possesses a strong expertise in commercial pharmacy, with in-depth knowledge of medications, their routes of administration, desired effects, adverse effects, and toxicity.
Currently, Dr Natália Marcéli Stephanes works as a Pharmacist at the Health Department of Santa Catarina State, where her role entails providing pharmaceutical scientific consulting services to judges.
Education:
- 2016 Bachelor in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2018 Master in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2023 PhD in Pharmacy at the Federal University of Santa Catarina, Brazil
The main publications of Dr Natália Marcéli Stephanes are:
Falchetti M ; Delgobo M, Zancanaro H, Almeida K, Das Neves RN, Dos Santos B, Stefanes NM, et al. Bishop Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Comput. Biol. Med [Internet]. 2023; 152:106347.
Feuser PM, Matos dos Santos PC, Cordeiro AP, Stefanes NM, Walter LO, Maioral MF, Santos-Silva MC, et al. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562). J Drug Deliv Sci Technol [Internet]. 2022; 67:102924.
Jacques AV, Stefanes NM, Walter LO, Perondi DM, Efe FL, Souza LFS, Sens L, et al. Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines. Bioorg. Chem [Internet]. 2021; 116:105315.
Duarte BF, Vieira DSC, Lisboa ML, Stefanes NM, Grando LJ, Santos-Silva MC. Características clínico-epidemiológicas de pacientes portadores de carcinoma de células escamosas de boca. Arquivos Catarinenses de Medicina. 2021; 50(2): 232–245.
Machado V, Jacques AV, Stefanes NM, Santos-Silva MC, Biavatti MW. Anti-leukemic activity of semisynthetic derivatives of Lupeol. Nat. Prod. Res. 2021; 35(22):4494-4501.
Bigolin A, Maioral MF, Stefanes NM, Mascarello A, Chiaradia-Delatorre LD, Nunes RJ, Yunes RA, et al. A novel sulfonamide derivative as a strong and selective apoptotic agent against hematological malignancies. Chem. Pap. 2020; 74:2965–2976.
Bigolin A, Maioral MF, Stefanes NM, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anticancer Drugs. 2020; 31(7):709-717.
Maioral MF, Stefanes NM, Neufeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC. Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med. Chem. 2020; 12(8):673–688.
Perondi DM, Jacques AV, Stefanes NM, Maioral MF, Sens L, Pacheco LA, Cury NM, et al. A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. Anticancer Drugs. 2019; 30(8):p 828-837.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Argenta DF, Dotto MER, Santos-Silva MC, et al. PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment. Eur. Polym. J. 2019; 119:335-343.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Santos-Silva MC, Nunes RJ, Parize AL, et al. A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity. Mater. Sci. Eng. C [Internet]. 2019; 105:110051.
Maioral MF, Stefanes NM, Bigolin A, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Miconidine acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest. New Drugs. 2019; 37:912–922.
Srefanes NM, Toigo J, Maioral MF, Jacques AV, Chiaradia-Delatorre LD, Perondi DM, Ribeiro AAB, et al. Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity. Bioorg. Med. Chem. 2019; 27(2):375-382.
Maioral MF, Bodack CN, Stefanes NM, Bigolin A, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochim. 2017; 140:48-57.
You can view some of Dr Natália’s work below and links to her professional profile below.
Research Gate: https://www.researchgate.net/profile/Natalia-Stephanes
Linkedin: https://www.linkedin.com/in/nataliamarceli/
In this article, we will discuss the use of Pantoprazole in the morning and Omeprazole at night. We will also discuss the potential benefits and risks of this approach.
Can you take Pantoprazole in the morning and Omeprazole at night?
Yes, you can take Pantoprazole in the morning and Omeprazole at night. Both Pantoprazole and Omeprazole belong to the class of proton pump inhibitors (PPIs) and they have similar mechanisms of action (1,2).
PPIs work by inhibiting the action of tiny pumps in the stomach lining called proton pumps, which release acid into the stomach (3). By reducing acid production, PPIs can help manage conditions like gastroesophageal reflux disease (GERD), heartburn, and ulcers, among others.
Pantoprazole and Omeprazole are recommended for individuals who experience excessive stomach acid, which can lead to discomfort and various digestive issues.
Potential benefits of taking Pantoprazole in the morning and Omeprazole at night
Taking Pantoprazole in the morning and Omeprazole at night might not provide additional nighttime protection against stomach acid. PPIs are meant to be taken in the morning, or any time of the day 30 minutes before meals (3).
It is absolutely okay to take Pantoprazole in the morning, preferably on an empty stomach. However, taking Omeprazole at night may not provide the same level of effectiveness.
The reason behind this is that Proton Pump Inhibitors (PPIs) like Omeprazole work best when taken about 30 minutes before meals (2). This timing allows them to suppress stomach acid production in response to food intake, which is when acid secretion is most active.
If you’re experiencing nighttime acid reflux or require acid protection during the night, solely taking Omeprazole before bedtime might not provide the optimal solution.
In clinical practice, healthcare providers often advise taking a PPI before meals to address the acid production triggered by food consumption.
To manage nighttime acid reflux more effectively, some healthcare providers suggest taking a PPI in the morning and a low-dose H2 receptor blocker like Famotidine at bedtime (4).
This combination can provide better results in preventing nighttime acid reflux and ensuring more comprehensive acid control throughout the day and night.
Potential risks of taking Pantoprazole in the morning and Omeprazole at night
There aren’t any known risks associated with taking Pantoprazole in the morning and Omeprazole at night. However, it’s essential to recognize that this approach may not offer significant benefits either.
The potential for side effects exists with any medication, including PPIs. People may experience side effects specific to each medication, but in general, these medications are well-tolerated by most individuals. However, it’s important to make sure that you’re not allergic to any of these meds.
What should you do if you experience nighttime acid reflux?
If you’re experiencing nighttime acid reflux and related symptoms, it’s best to reach out to your doctor or pharmacist. While taking Omeprazole at bedtime might not be that effective, taking it before dinner can control acid reflux.
Furthermore, taking an H2 blockade at night and twice daily dose of a PPI can help control your nighttime heartburn. It’s best to reach out to your doctor if your acid reflux is persistent or severe.
Conclusion
In this article, we have discussed the concomitant use of Pantoprazole in the morning and Omeprazole at night. We have also discussed the potential benefits and risks of this approach.
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References
1.-
Shah N, Gossman W. Omeprazole. 2023 Feb 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30969608. https://www.ncbi.nlm.nih.gov/books/NBK539786
2.-
Bernshteyn MA, Masood U. Pantoprazole. 2023 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29763120. https://www.ncbi.nlm.nih.gov/books/NBK499945
3.-
Ahmed A, Clarke JO. Proton Pump Inhibitors (PPI). 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32491317. https://www.ncbi.nlm.nih.gov/books/NBK557385
4.-
Orr WC, Harnish MJ. The efficacy of omeprazole twice daily with supplemental H2 blockade at bedtime in the suppression of nocturnal oesophageal and gastric acidity. Aliment Pharmacol Ther. 2003 Jun 15;17(12):1553-8. doi: 10.1046/j.1365-2036.2003.01594.x. PMID: 12823159. https://pubmed.ncbi.nlm.nih.gov/12823159/
