Can you take Sudafed in the morning and Benadryl at night?

In this article, we will discuss the use of Sudafed (Pseudoephedrine) in the morning and Benadryl (Diphenhydramine) at night. We will also discuss some potential benefits and risks of this combination.

Can you take Sudafed in the morning and Benadryl at night?

Yes, you can take Sudafed (Pseudoephedrine) in the morning and Benadryl (Diphenhydramine) at night. These medications are frequently used together to manage various cold, flu, and allergy symptoms. 

Sudafed is a nasal decongestant that narrows the blood vessels in your nasal passages, reducing swelling and congestion (1). This allows you to breathe more easily and can help alleviate symptoms like a stuffy or runny nose (1). 

Benadryl, on the other hand, is a first-generation sedative antihistamine that helps with allergy symptoms, like sneezing, runny nose, watery eyes, etc and can help you sleep (2). 

Taking Sudafed in the morning and Benadryl at night is a common approach for managing these symptoms, and you can also take them at the same time. 

In fact, Pseudoephedrine and Diphenhydramine – the active ingredients in Sudafed and Benadryl respectively – are available in various formulations in a combined form. 

Other combinations of an antihistamine and a nasal decongestant are also easily available, which give the same therapeutic benefits – NyQuil severe, which contains Doxylamine and Phenylephrine among other active ingredients (3).

However, it’s important to make sure that you don’t combine similar OTC formulations, like combining Benadryl with NyQuil or Sudafed with DayQuil. This can increase the risk of side effects, because of the overlapping active ingredients. 

Potential benefits of taking Sudafed in the morning and Benadryl at night

Taking Sudafed in the morning and Benadryl at night can offer several benefits when managing cold and flu symptoms (4).

As discussed earlier, Sudafed helps with nasal congestion and other symptoms like a runny or stuffy nose. It contains ingredients that can reduce the swelling of blood vessels in your nasal passages, allowing you to breathe more easily during the day. 

Since Sudafed can have stimulant effects and might interfere with sleep, it’s wise to take it in the morning to avoid potential sleep disturbances (1). 

On the other hand, Benadryl can help you sleep better. It has a sedative effect that can relieve allergy symptoms, including sneezing, itching, and a runny nose (2). By taking it at night, it can promote restful sleep without the risk of daytime drowsiness. 

The timing of these medications is indeed beneficial because it addresses your symptoms effectively while also considering their potential effects on sleep. 

This approach can help you feel more comfortable during the day and ensure a good night’s sleep, which is essential for a speedy recovery when dealing with cold and flu symptoms.

Potential risks of taking Sudafed in the morning and Benadryl at night

There aren’t any potential risks of taking Sudafed in the morning and Benadryl at night for healthy individuals, and these medications can also be taken at the same time without any side effects. However, people are different and can respond differently to medications. 

Although these meds don’t interact with one another, they may cause side effects in people who are sensitive to either one or both of these medications. 

For example, Sudafed can elevate blood pressure in some cases and it is a potential risk for people with hypertension or people who are at a higher risk of heart attacks (5). 

This is why it’s important to discuss using these medications with a doctor or pharmacist if you have an underlying health condition. It is also important to seek medical attention if you experience an allergic reaction after taking any of the two medications. 


In this article, we have discussed the use of Sudafed in the morning and Benadryl at night, and have talked about how this treatment approach can help manage various cold, flu, and allergy symptoms. We have also discussed some potential risks, which are important to discuss when a doctor. 

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