Can you take Mirtazapine with alcohol?

In this article, we will discuss whether it’s safe to take Mirtazapine, an antidepressant, with alcohol. We will also talk about the potential risks of this combination and who should avoid it completely.

Can you take Mirtazapine with alcohol?

No, it is not recommended to take Mirtazapine with alcohol, especially if you have just started taking the antidepressant. However, once you’re settled in, you can occasionally drink alcohol, but it’s still recommended to not take them at the exact same time. 

It is important to note that alcohol should not be used excessively with antidepressants (1). The use of alcohol can be dangerous for some people and can affect the treatment.

What are the potential risks of taking Mirtazapine with alcohol? 

Taking Mirtazapine with alcohol can lead to some health risks, including:

Sedation and mental impairment

Mirtazapine is a sedative antidepressant, which means it can cause drowsiness and affect your mental clarity. When alcohol is added to the mix, the sedative effect can become more pronounced, leading to increased drowsiness, impaired judgment, and difficulty concentrating (2,3). 

This combination can be dangerous, especially when performing tasks that require focus, such as driving.

Negative impact on mood

Alcohol is a depressant, and when consumed excessively, it can worsen feelings of sadness or hopelessness. If you’re already dealing with depression, alcohol can magnify these negative emotions and make you dwell on troubling thoughts, leading to a more challenging mental state (4).

However, some studies do suggest that Mirtazapine can help depressed alcoholics and can be used to help people recover from this addiction (5). However, it is important to limit the use of alcohol for Mirtazapine to work for that purpose. Taking the two together excessively will get you nowhere. 

Potential medication interactions

It’s essential to be cautious if you’re taking other medications along with Mirtazapine. Alcohol can interact with various drugs, including those used for other medical conditions, leading to unpredictable effects or reducing the effectiveness of your treatment.

General harmful effects of alcohol

Alcohol consumption is generally harmful, and it can negatively impact your recovery from depression (3). It can interfere with the effectiveness of antidepressant medications, including Mirtazapine. Additionally, alcohol can disrupt your sleep patterns, further worsening your mood and overall well-being (3).

To ensure your safety and well-being, it’s crucial to avoid alcohol while taking Mirtazapine. If you have questions or concerns about how Mirtazapine may interact with alcohol or other medications, consult your doctor.

Who should completely avoid the combination of Mirtazapine and alcohol? 

Certain individuals should completely avoid the combined use of Mirtazapine and alcohol. These include:

Liver disease

If you have liver problems or a history of liver disease, alcohol can further strain your liver function. Mirtazapine is processed by the liver, and alcohol can affect the liver’s ability to metabolize medications properly (3). 

Combining Mirtazapine with alcohol in such cases can lead to a higher risk of adverse effects on the liver.

Seizure disorders

Alcohol can lower the seizure threshold, making individuals with seizure disorders more susceptible to experiencing seizures (6). 

Mirtazapine has the potential to increase the risk of seizures, especially at higher doses. Combining alcohol with Mirtazapine in these cases could further elevate the seizure risk.

Concomitant use of other medications

If you’re taking other medications along with Mirtazapine, especially those that interact negatively with alcohol, it’s essential to avoid alcohol completely. Certain medications, when combined with alcohol, can lead to dangerous interactions, compromising your health.

History of substance abuse

Individuals with a history of substance abuse or those struggling with addiction should steer clear of alcohol while on Mirtazapine. Alcohol can worsen mental health conditions and impede the effectiveness of Mirtazapine in managing depressive symptoms.

In these cases, the risks associated with combining Mirtazapine and alcohol are significantly heightened, and it’s crucial to prioritize your health and well-being by refraining from alcohol consumption altogether. 

Why consulting your doctor before you combine Mirtazapine and alcohol is important?

Consulting your doctor before combining Mirtazapine and alcohol is of paramount importance to ensure your safety and well-being. While Mirtazapine is prescribed to help manage conditions like depression and anxiety, alcohol can interact with the medication, potentially leading to adverse effects. 

Your doctor plays a crucial role in understanding how these two substances may interact based on your individual health profile.

When discussing this combination with your doctor, several key points should be addressed to avoid any potential risks. Firstly, your complete medical history should be shared, including any preexisting health conditions or allergies. 

Conditions such as liver problems, seizure disorders, or a history of substance abuse can significantly impact how your body reacts to the combination of Mirtazapine and alcohol.

It’s also important to inform your doctor about all the medications you’re currently taking, both prescription and over-the-counter, as well as any supplements or herbal remedies. Some medications may have interactions with alcohol or affect how Mirtazapine works in your body.

Openly discussing your alcohol consumption habits is crucial. Be honest about how much and how often you consume alcohol. This information helps your doctor assess how alcohol may affect your health, especially when combined with Mirtazapine. 

Remember, these points are important and can significantly affect your life if you’re an alcoholic. So make sure you have a detailed and honest discussion with your provider about this and follow all the necessary instructions for safeguarding your physical and mental health.


In this article, we have discussed the concomitant use of Mirtazapine and alcohol. We have talked about some potential health risks associated with this combination and people who should completely avoid taking them together. 

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