Can you take Lorazepam in the morning and Trazodone at night?
By
Dr Natalia Marceli Stephanes (PhD)
Author bio
Dr Natália Marcéli Stephanes PhD is a Pharmacist with expertise in Drugs Administration and Toxicity; Discovery of New Drugs; Cancer Treatment; Biochemical Analyzes and Hematological Analyzes. She writes and reviews content on these topics.
Dr Natália Marcéli Stephanes’ Highlights:
- Pharmacist at the Department of Health of Santa Catarina State, Brazil
- PhD with a focus on oncology treatment
- Years of experience in commercial pharmacy
- Bachelor, Master and PhD degrees in Pharmacy at the Federal University of Santa Catarina
Professional Experience:
From her undergraduate studies to her Master’s and Doctorate degrees in Pharmacy, Dr Natália Marcéli Stephanes has participated in numerous scientific studies in the field of oncology and onco-hematology at the University Hospital of the Federal University of Santa Catarina, Brazil. Her research has focused on understanding the molecular and biochemical bases of malignant neoplasms and investigating safer and more effective therapeutic alternatives.
Dr Natália Marcéli Stephanes has also served as an assistant professor of haematology for undergraduate students at the Federal University of Santa Catarina. Additionally, she held the position of professor of Hospital Pharmacy at the Qualificar Technical School in Brazil, where she developed instructional materials for use in the Pharmacy Postgraduate Program at the Leonardo Da Vinci University Center.
In addition to her academic experiences, Dr Natália Marcéli Stephanes possesses a strong expertise in commercial pharmacy, with in-depth knowledge of medications, their routes of administration, desired effects, adverse effects, and toxicity.
Currently, Dr Natália Marcéli Stephanes works as a Pharmacist at the Health Department of Santa Catarina State, where her role entails providing pharmaceutical scientific consulting services to judges.
Education:
- 2016 Bachelor in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2018 Master in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2023 PhD in Pharmacy at the Federal University of Santa Catarina, Brazil
The main publications of Dr Natália Marcéli Stephanes are:
Falchetti M ; Delgobo M, Zancanaro H, Almeida K, Das Neves RN, Dos Santos B, Stefanes NM, et al. Bishop Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Comput. Biol. Med [Internet]. 2023; 152:106347.
Feuser PM, Matos dos Santos PC, Cordeiro AP, Stefanes NM, Walter LO, Maioral MF, Santos-Silva MC, et al. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562). J Drug Deliv Sci Technol [Internet]. 2022; 67:102924.
Jacques AV, Stefanes NM, Walter LO, Perondi DM, Efe FL, Souza LFS, Sens L, et al. Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines. Bioorg. Chem [Internet]. 2021; 116:105315.
Duarte BF, Vieira DSC, Lisboa ML, Stefanes NM, Grando LJ, Santos-Silva MC. Características clínico-epidemiológicas de pacientes portadores de carcinoma de células escamosas de boca. Arquivos Catarinenses de Medicina. 2021; 50(2): 232–245.
Machado V, Jacques AV, Stefanes NM, Santos-Silva MC, Biavatti MW. Anti-leukemic activity of semisynthetic derivatives of Lupeol. Nat. Prod. Res. 2021; 35(22):4494-4501.
Bigolin A, Maioral MF, Stefanes NM, Mascarello A, Chiaradia-Delatorre LD, Nunes RJ, Yunes RA, et al. A novel sulfonamide derivative as a strong and selective apoptotic agent against hematological malignancies. Chem. Pap. 2020; 74:2965–2976.
Bigolin A, Maioral MF, Stefanes NM, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anticancer Drugs. 2020; 31(7):709-717.
Maioral MF, Stefanes NM, Neufeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC. Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med. Chem. 2020; 12(8):673–688.
Perondi DM, Jacques AV, Stefanes NM, Maioral MF, Sens L, Pacheco LA, Cury NM, et al. A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. Anticancer Drugs. 2019; 30(8):p 828-837.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Argenta DF, Dotto MER, Santos-Silva MC, et al. PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment. Eur. Polym. J. 2019; 119:335-343.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Santos-Silva MC, Nunes RJ, Parize AL, et al. A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity. Mater. Sci. Eng. C [Internet]. 2019; 105:110051.
Maioral MF, Stefanes NM, Bigolin A, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Miconidine acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest. New Drugs. 2019; 37:912–922.
Srefanes NM, Toigo J, Maioral MF, Jacques AV, Chiaradia-Delatorre LD, Perondi DM, Ribeiro AAB, et al. Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity. Bioorg. Med. Chem. 2019; 27(2):375-382.
Maioral MF, Bodack CN, Stefanes NM, Bigolin A, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochim. 2017; 140:48-57.
You can view some of Dr Natália’s work below and links to her professional profile below.
Research Gate: https://www.researchgate.net/profile/Natalia-Stephanes
Linkedin: https://www.linkedin.com/in/nataliamarceli/
In this article, we will discuss the use of Lorazepam, a benzodiazepine, in the morning and Trazodone, an antidepressant, at night. We will also discuss the potential benefits and risks of taking this combination.
Can you take Lorazepam in the morning and Trazodone at night?
You can take Lorazepam in the morning and Trazodone at night, but only if recommended by your healthcare provider. Both Lorazepam and Trazodone are prescription medications and this combination should be prescribed very carefully (1,2).
Factors like the patient’s age, symptoms, pre-existing health conditions, and body response to such meds should be considered when deciding the best combination treatment. The combination of Lorazepam and Trazodone can be beneficial for some individuals.
For example, if you’re dealing with both anxiety and insomnia, your doctor might recommend this combination to address both issues (1,2). However, it’s essential to remember that everyone’s body reacts differently to medications.
What works well for one person may not be suitable for another. Some individuals might experience adverse effects or feel excessively drowsy, while others might not. Generally, Trazodone should not be taken at the same time as other sedative medications, like Lorazepam, Diazepam, etc.
Potential benefits of taking Lorazepam in the morning and Trazodone at night
Taking Lorazepam in the morning and Trazodone at night can offer potential benefits for some individuals. Lorazepam, when taken in the morning, can provide calming effects – as the medication is used to manage anxiety disorders and can help ease feelings of unease or nervousness (1).
Trazodone, when taken at night, serves a dual purpose. It’s primarily an antidepressant, which means it can lift your mood over time. Additionally, its sedative properties can help you sleep well at night (2).
So, by taking these medications as recommended, you can address anxiety and mood management in the daytime with Lorazepam and ensure a peaceful night’s sleep with Trazodone.
Potential risks of taking Lorazepam in the morning and Trazodone at night
Taking Lorazepam in the morning and Trazodone at night can have potential risks that need to be considered. These include:
Excess sedation
One of the main concerns is excessive drowsiness. Taking Lorazepam in the morning may lead to significant sedation for some individuals. This drowsiness can affect your daily activities, making it unsafe to operate heavy machinery or drive a car (1).
Additive side effects
Combining these medications can sometimes lead to additive side effects. This means that the sedative effects of both drugs may intensify when taken together, potentially causing more drowsiness, dizziness, or coordination problems (1,2).
General intolerance
Some people may not be able to tolerate this treatment approach generally. The dosage strengths of these meds are also very important to ensure their safe and effective use. However, there are plenty of other combinations that may provide more appropriate benefits than this one.
Important considerations before taking Lorazepam in the morning and Trazodone at night
Some important considerations before taking Lorazepam in the morning and Trazodone at night include:
Duration of Lorazepam use
Lorazepam is a controlled medication, and it’s not meant for long-term use due to the potential for dependence and tolerance (3). It’s essential to discuss with your doctor how long you’ll be taking it and explore alternative treatments for chronic anxiety.
Dosage strengths
The doses of both medications must be carefully adjusted. Incorrect dosages can increase the risk of side effects. Your healthcare provider will determine the appropriate strengths based on your specific needs and medical history.
Underlying mental disorder
If you have an underlying mental health condition, such as bipolar disorder, combining these medications can be complex. It’s vital to work closely with your doctor to ensure this combination is suitable for your condition, as it may worsen symptoms in some cases.
Age considerations
Elderly individuals may be more susceptible to the sedative effects of both Lorazepam and Trazodone. This can lead to falls or persistent drowsiness throughout the day, which can impact daily activities.
Remember, it’s important to make sure that you only take this combination if prescribed by your doctor and stick to the proper dose and frequency.
Conclusion
In this article, we have discussed the use of Lorazepam, a benzodiazepine, in the morning and Trazodone, an antidepressant, at night. We have also discussed the potential benefits and risks of taking this combination, and some important things to consider before taking it.
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References
1.-
Shin JJ, Saadabadi A. Trazodone. 2022 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29262060. https://www.ncbi.nlm.nih.gov/books/NBK470560
2.-
Ghiasi N, Bhansali RK, Marwaha R. Lorazepam. 2023 Jan 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30422485. https://www.ncbi.nlm.nih.gov/books/NBK532890
3.-
Schmitz A. Benzodiazepine use, misuse, and abuse: A review. Ment Health Clin. 2016 May 6;6(3):120-126. doi: 10.9740/mhc.2016.05.120. PMID: 29955458; PMCID: PMC6007645. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007645/
