Can you take Effexor and Trazodone together? (3+ effects)

In this article, we will discuss whether Effexor and Trazodone can be taken together in combination for the treatment of the intended condition or not. We will also discuss what research suggests on this, the potential benefits of this combination and the possible side effects of combining Effexor and Trazodone.

Can you take Effexor and Trazodone together?

Yes, in some cases healthcare providers may prescribe Effexor and Trazodone together as a combination therapy, to address complex mental health conditions.

Effexor (venlafaxine) and Trazodone are two types of medicines used for different mental health issues. Effexor helps with depression and anxiety while Trazodone is mainly used for sleeping problems (insomnia) and sometimes for depression. (1)

However, this combination should only be used under the guidance and monitoring of a healthcare provider. They will carefully evaluate your specific condition and will keep a close eye on how you’re doing. (1)

What does research suggest?

According to a case study, researchers experimented on how adding Trazodone to the treatment of 50 depressed patients, who were already taking Effexor (venlafaxine) for 4 weeks would affect their sleep and mood. (3)

They found that some patients had trouble sleeping even with the medicines they were taking. They split the patients into 2 groups, one that did not get Trazodone (G1) and one that did get trazodone (G2).

Both groups were similar in the beginning but the G1 patients had more trouble with sleep and feeling anxious. When they added Trazodone the G2 patient’s sleep got better but they still felt anxious. (3)

So, it seems like Trazodone might help with sleep problems but it doesn’t do much for anxiety in these patients. (2)

What are the potential benefits of combining Effexor and Trazodone?

Combining Effexor and Trazodone can offer potential benefits in specific situations particularly when a person is dealing with both depression or anxiety and sleep problems. (2)

  • Comprehensive treatment: Effexor is great for helping when you are feeling sad or anxious, while Trazodone can make it easier for you to get a good night’s sleep. Using them together can take care of both these things together. 
  • Sleep improvement: Trazodone can make you fall asleep or stay asleep easier when you are feeling down and anxiety is messing with your sleep.
  • Enhance mood: Effexor can give your mood a lift and reduce those feelings of sadness and anxiety.

What are the possible side effects of combining Effexor and Trazodone?

Combining Trazodone and Effexor can have some effects on your body. Here’s what you might experience: (4)

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Nausea
  • Headaches
  • Blood pressure changes
  • Possible interactions (Combining medications can sometimes change how your body processes them. Your doctor will check for this.)
  • Serotonin syndrome

Remember, always talk to your doctor before changing or mixing the medicines. They can help manage these side effects and find the right treatment for you. 

What precautions you should take when combining Effexor and Trazodone?

When you are taking both Effexor and Trazodone together, it’s important to be cautious and follow these steps: (6)

  • Medical supervision: Consult with your healthcare provider and don’t mix these medicines on your own.
  • Dosage and timings: Follow your doctor’s advice on how much of each medicine to take and when to take them, such as morning or night. 
  • Monitoring: Stay in regular contact with your healthcare provider. They will monitor your progress, assess if any side effects are present and make necessary adjustments to your treatment plan.
  • Serotonin Syndrome awareness: Be aware of the signs of serotonin syndrome, which can be serious. If you feel very agitated and confused, your blood pressure is high and you are experiencing a rapid heartbeat, get medical help right away. 
  • Avoid alcohol consumption: Alcohol can interact with both Effexor and Trazodone and can make you feel more drowsy.
  • Medical history: Inform your healthcare provider of your complete medical history including any allergies.

It’s important to follow the recommendations and guidance of your healthcare provider for the best therapeutic outcome. 


In this article, we have discussed the efficacy and possible side effects when taking Effexor and Trazodone together as a combination therapy for the treatment of both depression or anxiety and insomnia.

 In my opinion, combining Effexor and Trazodone can offer benefits for individuals who are dealing with both mood-related issues and sleep disturbances. 

However, it’s essential to seek professional guidance and not combine these medications on your own. Monitoring is important to ensure your safety and balanced treatment.

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