Can you take Allopurinol and Indomethacin together? 

Can you take Allopurinol and Indomethacin together? 

Yes, you can take Allopurinol and Indomethacin together. These two meds are frequently used for the management and treatment of gout, which is a condition commonly triggered by an increased amount of uric acid in your body. 

Role of Allopurinol 

Allopurinol is used to reduce the amount of uric acid in your body, which prevents gout, and reduces the frequency of gout flare-ups, and the formation of certain types of kidney stones (1). 

Allopurinol basically inhibits the synthesis of uric acid to produce its effects and can also be used in people who have high uric acid levels because of cancer or chemotherapy. 

Role of Indomethacin 

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID), which can be used for the management of pain and inflammation associated with gout (2). 

Risks and side effects of taking Allopurinol and Indomethacin together

Allopurinol and Indomethacin don’t chemically interact with one another and do not cause similar side effects. When these two are prescribed together, the doses are usually adjusted and they are always within the safety window. 

However, high doses of these meds can cause side effects of their own, if not additive. On the other hand, a small number of people could be allergic to either one or both of these meds. 

So, it’s best to monitor your symptoms and reach out to your healthcare provider if you notice anything unusual. Commonly expected side effects are:

  • Nausea 
  • Vomiting 
  • Diarrhoea 
  • Upset stomach 
  • Acid reflux 
  • Abdominal pain
  • Drowsiness 
  • Ringing in ears. 

Both indomethacin and allopurinol can cause some rare and serious side effects, like an allergic reaction, unexplained weight changes, etc. So, make sure you keep a close eye on your side effects and report them to your doctor.

Don’t start taking Allopurinol and Indomethacin without consulting your doctor first 

It’s always best to talk to your doctor about your symptoms and stick to the meds prescribed specifically for you. I don’t ever recommend starting to take any prescription medication without knowing for certain what you’re actually going through. 

You may have more reasons to go to your doctor if your gout is not diagnosed yet. Your doctor will ask you for some blood tests to check the current amount of uric acid in your blood and the dose of Allopurinol is adjusted according to the level of uric acid. 

If it’s not that high or at the borderline, your doctor may not even prescribe the medication for that. This is why you should always talk to your doctor before combining any medication, even if you’ve heard hundreds of therapeutic benefits of that combination. You need to make sure it’s the right one for you. 

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National Library of Medicine (US). Allopurinol. [updated 2021 May 15]. In: MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); [cited 2023 Mar 07]. Available from:


National Library of Medicine (US). Indomethacin. [updated 2021 May 15]. In: MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); [cited 2023 Mar 07]. Available from: