Can you switch from Mirtazapine to Trazodone?

This article will discuss whether you can switch from Mirtazapine to Trazodone. We will also discuss the potential benefits of this antidepressant transition and what one should expect when it happens. We will also talk about some reasons that may lead to Mirtazapine discontinuation.

Can you switch from Mirtazapine to Trazodone?

Yes, you can switch from Mirtazapine to Trazodone if your doctor believes that Trazodone will prove to be more beneficial for you. Both Mirtazapine and Trazodone are effective antidepressants with sedative properties that can help manage symptoms (1,2). 

Mirtazapine is a generally well-tolerated medication and many people have shared their success stories. However, it may not be the best choice for you (2).

If you find that Mirtazapine has not adequately addressed your symptoms, your doctor may consider transitioning you to Trazodone. However, it’s important to note that this transition should only be done under a doctor’s supervision. 

It is essential for ensuring a smooth and safe transition between antidepressants, as your doctor can monitor your progress, manage any potential side effects, and make necessary adjustments to your treatment plan.

What is the best way to switch from Mirtazapine to Trazodone?

The best way to switch from Mirtazapine to Trazodone can vary from person to person, and this should be determined by your doctor. Generally, a common switching strategy is the cross-taper approach (3). 

In this method, your doctor gradually reduces the dosage of Mirtazapine while simultaneously introducing the new medication, Trazodone, starting at the lowest effective dose (3). 

This cross-taper strategy ensures that you’re not abruptly discontinuing Mirtazapine, which can lead to withdrawal symptoms while allowing Trazodone to build up in your system gradually. It helps to minimize potential side effects or disruptions in your treatment (4). 

Your doctor will carefully monitor your progress during this transition to ensure it’s going smoothly and make any necessary adjustments to the dosages as needed. Remember, the key here is to work closely with your healthcare provider throughout the process. 

What reasons can lead to Mirtazapine withdrawal? 

Several reasons can lead to considering withdrawal from Mirtazapine. Some individuals may experience side effects from the medication that can be bothersome or uncomfortable. 

These side effects can include drowsiness, increased appetite leading to weight gain, dizziness, and dry mouth, among others (2). Additionally, not everyone responds the same way to antidepressant medications like Mirtazapine. 

Some people may find that it doesn’t effectively alleviate their symptoms of depression or anxiety, making them explore other treatment options (2). It’s important to discuss any concerns or reasons for discontinuation with a healthcare provider before stopping Mirtazapine. 

Abruptly discontinuing this medication can lead to withdrawal symptoms and should be done under the guidance of a medical professional. 

What to expect when switching from Mirtazapine to Trazodone?

When you switch from Mirtazapine to Trazodone, there are a few things to expect. The new medication, Trazodone, might not show its full effects immediately – it could take some time to start working and you might experience some initial side effects – like nausea, dizziness, nightmares, etc (1). 

These side effects usually improve within a few days as your body adapts to the new antidepressant. It’s important to understand that finding the right antidepressant for you can be a process of trial and error. 

Not everyone responds the same way to medications, and it might take a few attempts to finalise the best treatment strategy that works for you. 

Remember to follow your doctor’s directions closely throughout this transition. Maintaining a healthy lifestyle with proper sleep, regular exercise, and a balanced diet can also positively impact your overall well-being. 


In this article, we have discussed switching from Mirtazapine to Trazodone. We have also discussed some reasons that can possibly lead to Mirtazapine withdrawal and what to expect after the transition.

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Shin JJ, Saadabadi A. Trazodone. 2022 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29262060.


Jilani TN, Gibbons JR, Faizy RM, Saadabadi A. Mirtazapine. 2022 Sep 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30085601.


National Prescribing Service Limited. Guidelines for switching antidepressants. [Internet]. NPS MedicineWise; 2010. Available from:


Keks N, Hope J, Keogh S. Switching and stopping antidepressants. Aust Prescr. 2016 Jun;39(3):76-83. doi: 10.18773/austprescr.2016.039. Epub 2016 Jun 1. PMID: 27346915; PMCID: PMC4919171.

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