Can you switch from 10mg of Citalopram to 50mg of Sertraline?

In this article, we will discuss switching from Citalopram to Sertraline – both of which are selective serotonin reuptake inhibitors (SSRIs). We will also discuss some switching strategies and what one must do to ensure a safe transition.

Can you switch from 10mg of Citalopram to 50mg of Sertraline?

You can switch from 10mg of Citalopram to 50mg of Sertraline if your healthcare provider advises this transition (1,2). Antidepressant switching is quite common and many people try multiple antidepressants before sticking to the one that works for the best in their case. 

However, the antidepressant transition should be carefully carried out under your doctor’s supervision. The antidepressant-switching strategy should be decided by your doctor and the dosage strength of the new antidepressant should be determined carefully.

What is the best switching strategy to switch from Citalopram to Sertraline?

When it comes to switching from Citalopram to Sertraline, it’s crucial to work closely with your healthcare provider. Your doctor knows about your complete medical history, understands why you’re transitioning from Citalopram, and is aware of the duration you’ve been on it. 

With this valuable information, your doctor can determine the most suitable switching strategy for you. Typically, since both Citalopram and Sertraline belong to the same class of antidepressants, there are two primary switching strategies to consider: the direct switch and the cross-taper (3). 

Direct switching

The direct switch involves discontinuing the use of your old antidepressant, Citalopram, and directly initiating the new one, Sertraline. This approach is generally employed when switching between antidepressants within the same class (3). However, it is not suitable for everyone.

Cross tapering

The cross-taper strategy involves gradually reducing the dose of your current antidepressant, Citalopram, while simultaneously introducing the new one, Sertraline, starting from the lowest effective dose. This method allows for a smoother transition between medications (3).

Ultimately, the choice between these strategies is a decision that should be made by your doctor, taking into account your unique circumstances and medical history.

What are the dosage recommendations for Sertraline?

The recommended dosage for Sertraline typically starts at 50 milligrams once a day for adults, and you can take it either in the morning or evening (4). 

Your doctor might make adjustments to your dose based on your individual needs, but generally, it doesn’t exceed 200 mg per day for adults (4). 

For children, the appropriate dose must be determined by their doctor, as it varies based on their specific circumstances. Always follow your healthcare provider’s guidance regarding the correct dosage for your situation to ensure safe and effective treatment.

How to ensure a safe transition from Citalopram to Sertraline?

Ensuring a safe transition from Citalopram to Sertraline is important for your physical and mental well-being. It is important to follow your doctor’s directions properly for a smooth antidepressant transition. 

If your healthcare provider recommends a cross-taper strategy, where you gradually reduce Citalopram while introducing Sertraline, it’s essential to adhere to their prescribed doses and timing. 

This approach helps minimize potential withdrawal symptoms and ensures a smoother transition. Moreover, patience is key during this transition. Understand that Sertraline may take some time to exhibit its full therapeutic effects. 

Don’t worry if you experience initial side effects; many of these typically subside within a few days as your body adjusts to the new medication. Early side effects of Sertraline may include nausea, diarrhoea, insomnia, acid reflux, metallic taste, etc.

However, always report any unusual or concerning side effects to your doctor. Remember, don’t hesitate to discuss any questions or uncertainties with your doctor. Clear communication with your healthcare provider is essential to ensure your transition to Sertraline is safe and effective. 


In this article, we have discussed switching from Citalopram to Sertraline. We have also discussed typical switching strategies and what one should do to ensure a safe and smooth transition. 

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Sharbaf Shoar N, Fariba KA, Padhy RK. Citalopram. 2021 Dec 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29489221.


Singh HK, Saadabadi A. Sertraline. 2023 Feb 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31613469. Available from:


National Prescribing Service Limited. Guidelines for switching antidepressants. [Internet]. NPS MedicineWise; 2010. Available from:


The Food and Drug Administration (FDA). HIGHLIGHTS OF PRESCRIBING INFORMATION. ZOLOFT (sertraline hydrochloride) tablets, for oral use. Available from:

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