Does Zoloft cause a metallic taste in your mouth? 

Does Zoloft cause a metallic taste in your mouth? 

Zoloft may cause a metallic taste in your mouth. This side effect is not that common and is reported by very few people. However, it could become quite disturbing and make food undesirable for you. 

The exact reason why Zoloft gives off a bad taste is not fully known, but the way this antidepressant works could be the culprit. The incidence of this side effect was found more common in people with higher doses of Zoloft, as compared to those who were taking lower doses. 

However, the unpleasant metallic taste is expected to go away with time. Most side effects of Zoloft begin to subside on their own within 2-4 weeks. However, some may linger for much longer than that. Make sure you report this side effect to your doctor. 

Zoloft-induced altered sense of taste can cause loss of appetite in some people, which can lead to weight loss if the affected individual continues to consume a lesser amount of calories. Zoloft can also increase salivation in some individuals. Although it is rare, it can be bothersome.

What does research suggest?

Research suggests that Zoloft (Sertraline) and other SSRIs can alter the sense of taste. Some people may experience a bitter taste in their mouth, and some may define it to be ‘metallic’, similar to the taste of blood in the mouth (1). 

Several studies have indicated that Zoloft and other SSRIs may not affect your sense of taste as much as other antidepressants can, like TCAs. however, the metallic or altered taste is a potential side effect of Zoloft among some other oral and dental side effects (2). 

What to do if Zoloft gives off a bad metallic taste in your mouth? 

There are a few things you can do if Zoloft gives off a metallic taste in your mouth. These are:

Take your antidepressant with food

If Zoloft starts to give off a bad taste right when you place it in your mouth, taking it with food can help mask the taste. You can take this med with something sweet, like pudding or applesauce for better results. 

Try salt water gargles

You can try gargling with lukewarm salt water to get rid of the Zoloft-induced metallic taste. This has helped some people and you can definitely try it too. However, it’s still not a promising solution and the bad taste may come back. 

Drink plenty of water 

Make sure you drink plenty of water to wash out the bad metallic taste in your mouth. You can also add fruits to make detox water, which will not only taste better but will fill you up with antioxidants. Adding citrus fruits like oranges and lemons can help. 

Chew gum

Chewing gum can help overcome the bad metallic taste in your mouth by increasing salivation. The taste of the gum can also mask the metallic taste. However, I recommend opting for sugar-free gums to stay on the healthier side. Too much sugar is never good for your health. 

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Schiffman SS. Influence of medications on taste and smell. World J Otorhinolaryngol Head Neck Surg. 2018 Mar 26;4(1):84-91. doi: 10.1016/j.wjorl.2018.02.005. PMID: 30035266; PMCID: PMC6051304. Available from:


Daly C. Oral and dental effects of antidepressants. Aust Prescr. 2016 Jun;39(3):84. doi: 10.18773/austprescr.2016.035. Epub 2016 Jun 1. PMID: 27350018; PMCID: PMC4919175. Available from:

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