Can you cut Amoxicillin in half? 

Can you cut Amoxicillin in half? 

Yes, you can cut Amoxicillin in half. This antibiotic is safe to cut if you find it difficult to swallow the tablets whole. If dose reduction is why you’re cutting Amoxicillin tablets, make sure you talk to your healthcare provider before that. 

It is not recommended to reduce your recommended antibiotic dose. Bacterial infections should be treated properly to ensure the proper eradication of bacteria (1), which is why you shouldn’t reduce your dose without consulting your doctor first.

However, Amoxicillin may cause gastrointestinal disturbances and some people may try reducing their dose because of the disturbing side effects. If Amoxicillin is being heavy on your stomach, try taking it with food. You should also take probiotics to replenish the good gut bacteria. 

Risks associated with cutting Amoxicillin in half

Most Amoxicillin tablets can be cut in half without a problem, but you need to make sure of something. If you’re cutting the tablets that are not scored, you need to cut them into two equal halves. 

This is because unequal halves can cause variation in dose uniformity and you may end up taking more or less than the prescribed dose. Another important thing is to properly secure the other half of the tablet that you’re not taking right away. 

Split tablets are not as stable as whole tablets because they are vulnerable to moisture attack, which can attract the stability and purity of the tablets.

This is why you have to place them properly to protect them from moisture penetration. It is also important to not split all of your prescription Amoxicillin at once. Just split the one you’re about to take. 

Alternatives to cutting Amoxicillin 

Amoxicillin is available in a wide variety of dosage forms and you can easily find a good alternative to cutting the tablets. Ask your pharmacist for an oral liquid suspension or chewable Amoxicillin tablets for your ease of administration. 

However, make sure you know how much of the new dosage form you will have to take to equal your doctor’s prescribed dose. 

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PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 33613, Amoxicillin. Available from: