Can Tylenol PM raise blood pressure? 

Can Tylenol PM raise blood pressure?

Tylenol PM is not commonly associated with high blood pressure as a side effect. This is considered one of the safest pain killers and occasional users are usually free from side effects. Tylenol PM contains two active ingredients – Acetaminophen and Diphenhydramine (1,2).

Although occasional use of Tylenol PM is considered safe for most people, chronic use may increase blood pressure – according to a recent study. It’s a known fact that when you use some medication continuously for a long period of time, you are bound to experience some changes in your body. 

Long-term use of Tylenol PM can also damage your liver, depending on the dosage (3). If you’re a chronic Tylenol PM user and you think the medication is now affecting your blood pressure, talk to your healthcare provider. 

Your doctor will rule out other possible factors and will determine if the drug is solely responsible for it or not. If yes, your doctor will guide you regarding the further use of Tylenol PM. 

Tylenol PM can also cause some side effects, as it is a combination of two medications. It may also cause a false positive on a drug test, as diphenhydramine can show false positive results for opioids. However, this is not considered common.

What factors can affect your blood pressure while taking Tylenol PM?

While Tylenol PM itself does not increase blood pressure, there are factors that can affect your blood pressure while taking it. Here are some important considerations:

Other medications

If you’re taking other medications along with Tylenol PM, such as blood pressure medications or medications that can affect blood pressure, they may have an impact on your blood pressure levels. 

It’s essential to be aware of any potential interactions between Tylenol PM and your other medications. Incompatible combinations can cause various adverse effects – like the use of Tylenol PM with Benadryl or any other sedative antihistamine can cause increased sedation. (4)

Individual response

Each person may have a different response to medications, including Tylenol PM. While it may not directly increase blood pressure in most individuals, some people may have a unique reaction or sensitivity that can affect their blood pressure. 

It’s important to monitor your blood pressure regularly and consult with your healthcare provider if you have any concerns.

Underlying health conditions

Certain health conditions, such as cardiovascular disease or hypertension (high blood pressure), can influence blood pressure levels. If you have a pre-existing condition, it’s crucial to discuss the use of Tylenol PM with your doctor to ensure it is safe and appropriate for you.

Lifestyle factors

Lifestyle factors, such as stress, diet, exercise, and alcohol consumption, can impact blood pressure. It’s important to maintain a healthy lifestyle, including regular physical activity, a balanced diet, stress management techniques, and limiting alcohol intake, to help maintain stable blood pressure levels.

What to do if your blood pressure raises while taking Tylenol PM?

If you notice that your blood pressure is rising while taking Tylenol PM, it’s important to discuss it with your healthcare provider. Your doctor will rule out any underlying condition that could be responsible for affecting your blood pressure, as Tylenol PM is not commonly known for such a side effect. 

However, each individual is unique and can respond differently to medications. If your blood pressure continues to rise despite using Tylenol PM, your healthcare provider may recommend alternative medications that are less likely to affect your blood pressure. 

They can suggest suitable alternatives based on your medical history, current condition, and any other medications you may be taking.

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Gerriets V, Anderson J, Nappe TM. Acetaminophen. 2022 Sep 18. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29493991.


Sicari V, Zabbo CP. Diphenhydramine. 2022 Jul 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30252266.


Barker JD Jr, de Carle DJ, Anuras S. Chronic excessive acetaminophen use and liver damage. Ann Intern Med. 1977 Sep;87(3):299-301. doi 10.7326/0003-4819-87-3-299. PMID: 900673. Available from:


LABEL: TYLENOL PM EXTRA STRENGTH- acetaminophen and diphenhydramine hydrochloride tablet, film coated. Available from: