Can Trazodone cause heart pounding? 

Can Trazodone cause heart pounding? 

Trazodone may cause heart pounding in some people. Although cardiac side effects are not common on standard doses of Trazodone, it could still affect some people. 

Trazodone is normally not considered an ideal antidepressant to be used in people who have active cardiac disease, this is because it is more cardiotoxic than other antidepressants. 

If we talk about a healthy individual with this medication, he/she may not experience cardiac side effects. Heart pounding could also be an early side effect in someone who’s new to Trazodone or antidepressants in general. 

In such cases, heart palpitations go away on their own, as the body adjusts to the medication. On the other hand, if you’re a cardiac patient taking Trazodone or someone who frequently has high blood pressure and it makes your heart pound, immediately report it to your healthcare provider. 

What does research suggest?

There is limited research on the Effects of Trazodone on heart health.  studies indicate that Trazodone does not cause cardiac side effects and its generally considered safe to be used in cardiac patients, as compared to tricyclic antidepressants (1).  

The research also suggests that Trazodone does not exacerbate the symptoms of pre-existing cardiac diseases, like ventricular arrhythmia. However, it may cause palpitations during the early course of the treatment.

What to do if Trazodone causes heart pounding? 

If you’re new to Trazodone and have no history of cardiac disease, Trazodone may make your heart pound a little during the early course of your treatment – but this side effect shouldn’t be a concerning one. 

In most cases, early side effects of Trazodone begin to subside within a few weeks, as your body adjusts to the medication. However, if you have a history of cardiac diseases or high blood pressure, I recommend reaching out to your healthcare provider. 

People who are taking Trazodone for insomnia usually take lower doses and they may experience relatively milder side effects as compared to those taking Trazodone for depression. 

Trazodone can affect some people more than others. It can also cause QT prolongation in some cases. It’s always best to talk to your doctor about your side effects to make sure the drug is not damaging your body or affecting your organs. 

Final words

Although Trazodone is not known for causing cardiac side effects, and it does not exacerbate pre-existing arrhythmias, some people may not do so well on this antidepressant. This is why you should properly monitor your side effects and keep your doctor informed. 


  1. Himmelhoch JM, Schechtman K, Auchenbach R. The role of trazodone in the treatment of depressed cardiac patients. Psychopathology. 1984;17 Suppl 2:51-63. doi: 10.1159/000284093. PMID: 6201941. Available from: 

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