Can Mirtazapine cause excessive hunger?

In this article, we will discuss Mirtazapine-induced excessive hunger – which is a known side effect of this antidepressant. We will also discuss some research studies and some tips to prevent weight gain while Mirtazapine spikes your cravings. 

Can Mirtazapine cause excessive hunger?

Yes, Mirtazapine can cause excessive hunger.  It’s not uncommon for people to report an increased appetite while taking this medication. In fact, Mirtazapine is known for causing weight gain in some individuals precisely because it can make you feel hungrier (1,2). 

However, it’s important to note that everyone is unique, and how they respond to medication can vary. Not everyone will experience this side effect, and some individuals may have different reactions to Mirtazapine.

What does research suggest?

Several research studies have linked Mirtazapine to excessive hunger. 

In one research study, researchers looked at the effects of mirtazapine on the metabolism of healthy men. To do this, they had 10 healthy men follow a strict routine for nutrition, sleep, and exercise for three weeks. Then, they gave these men 30 mg of Mirtazapine daily for a week (3).

The results showed that, even without significant weight gain or changes in energy expenditure, Mirtazapine increased feelings of hunger and cravings for sweets. It also shifted the body’s preference for using carbohydrates for energy and increased insulin and C-peptide release after eating (3).

Another study presented a case of Mirtazapine-induced sleep-related eating disorder (SRED). (4)

The study indicated that SRED episodes involve eating unusual or even harmful things, sleep disruptions leading to daytime fatigue, sleep-related injuries, engaging in risky behaviours while seeking or preparing food, loss of appetite in the morning, and negative health effects from binge eating high-calorie foods (4).

The study included that Mirtazapine may trigger this condition, as it works by increasing serotonin release through various mechanisms. It blocks specific receptors in the nervous system, which can help with sleep problems and appetite. 

Additionally, it has sedative and appetite-enhancing effects due to its interaction with histamine receptors (4).

Another study indicated that Mirtazapine can increase appetite and weight in elderly underweight individuals (5). 

A study was conducted on older patients who were underweight and prescribed antidepressants during hospitalisation. It was found that Mirtazapine was commonly prescribed to underweight older patients compared to other antidepressants (5).

These studies indicate that Mirtazapine does indeed make you hungrier, which can be beneficial in some cases and harmful in others.

What to do if Mirtazapine makes you excessively hungry?

If you find that Mirtazapine is making you excessively hungry, it’s important to talk to your doctor about it. This increased appetite can have different effects on different people. 

For some, especially those dealing with anorexia alongside depression, it might be a helpful side effect as it can aid in gaining weight. 

However, for others, it can be undesirable and lead to weight gain, which may worsen their depression by affecting their self-esteem and social interactions.

In such cases, your doctor may consider reducing the dose or exploring alternative medications to help manage this side effect and ensure your overall well-being. 

Helpful tips to prevent weight gain when Mirtazapine makes you hungrier

Some helpful tips that can help you prevent weight gain when Mirtazapine makes you hungrier include:

• Opt for nutrient-dense, low-calorie foods like fruits, vegetables, and lean proteins. This way, you can satisfy your hunger without consuming excessive calories.

• Instead of three large meals, consider eating smaller, more frequent meals throughout the day. This can help you manage your hunger and prevent overeating.

• Drink plenty of water throughout the day. Sometimes, our bodies confuse thirst with hunger, so staying hydrated can help control unnecessary eating.

• Incorporate regular physical activity into your routine. Exercise not only burns calories but also has mood-lifting benefits, and can help you lose weight while taking Mirtazapine.

• Sugary foods and complex carbohydrates can lead to energy spikes and crashes, which may trigger more frequent eating. Try to limit your intake of these foods.

• Alcohol can increase appetite and lower inhibitions, potentially leading to overeating. Moderation is key if you choose to consume alcohol.

• Pay attention to what and when you’re eating. Sometimes, we eat out of habit or boredom rather than true hunger. Mindful eating can help you distinguish between the two.

Remember, everyone’s response to medications can vary, so it’s crucial to work closely with your doctor to find the best approach for your individual situation.

Conclusion

In this article, we have discussed Mirtazapine-induced excessive hunger. We have discussed some research studies to understand how Mirtazapone is linked to this side effect. We have also talked about some tips that can help you when Mirtazapine makes you hungrier. 

References