Can you take Benadryl and Advil together?
By
Dr Natalia Marceli Stephanes (PhD)
Author bio
Dr Natália Marcéli Stephanes PhD is a Pharmacist with expertise in Drugs Administration and Toxicity; Discovery of New Drugs; Cancer Treatment; Biochemical Analyzes and Hematological Analyzes. She writes and reviews content on these topics.
Dr Natália Marcéli Stephanes’ Highlights:
- Pharmacist at the Department of Health of Santa Catarina State, Brazil
- PhD with a focus on oncology treatment
- Years of experience in commercial pharmacy
- Bachelor, Master and PhD degrees in Pharmacy at the Federal University of Santa Catarina
Professional Experience:
From her undergraduate studies to her Master’s and Doctorate degrees in Pharmacy, Dr Natália Marcéli Stephanes has participated in numerous scientific studies in the field of oncology and onco-hematology at the University Hospital of the Federal University of Santa Catarina, Brazil. Her research has focused on understanding the molecular and biochemical bases of malignant neoplasms and investigating safer and more effective therapeutic alternatives.
Dr Natália Marcéli Stephanes has also served as an assistant professor of haematology for undergraduate students at the Federal University of Santa Catarina. Additionally, she held the position of professor of Hospital Pharmacy at the Qualificar Technical School in Brazil, where she developed instructional materials for use in the Pharmacy Postgraduate Program at the Leonardo Da Vinci University Center.
In addition to her academic experiences, Dr Natália Marcéli Stephanes possesses a strong expertise in commercial pharmacy, with in-depth knowledge of medications, their routes of administration, desired effects, adverse effects, and toxicity.
Currently, Dr Natália Marcéli Stephanes works as a Pharmacist at the Health Department of Santa Catarina State, where her role entails providing pharmaceutical scientific consulting services to judges.
Education:
- 2016 Bachelor in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2018 Master in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2023 PhD in Pharmacy at the Federal University of Santa Catarina, Brazil
The main publications of Dr Natália Marcéli Stephanes are:
Falchetti M ; Delgobo M, Zancanaro H, Almeida K, Das Neves RN, Dos Santos B, Stefanes NM, et al. Bishop Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Comput. Biol. Med [Internet]. 2023; 152:106347.
Feuser PM, Matos dos Santos PC, Cordeiro AP, Stefanes NM, Walter LO, Maioral MF, Santos-Silva MC, et al. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562). J Drug Deliv Sci Technol [Internet]. 2022; 67:102924.
Jacques AV, Stefanes NM, Walter LO, Perondi DM, Efe FL, Souza LFS, Sens L, et al. Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines. Bioorg. Chem [Internet]. 2021; 116:105315.
Duarte BF, Vieira DSC, Lisboa ML, Stefanes NM, Grando LJ, Santos-Silva MC. Características clínico-epidemiológicas de pacientes portadores de carcinoma de células escamosas de boca. Arquivos Catarinenses de Medicina. 2021; 50(2): 232–245.
Machado V, Jacques AV, Stefanes NM, Santos-Silva MC, Biavatti MW. Anti-leukemic activity of semisynthetic derivatives of Lupeol. Nat. Prod. Res. 2021; 35(22):4494-4501.
Bigolin A, Maioral MF, Stefanes NM, Mascarello A, Chiaradia-Delatorre LD, Nunes RJ, Yunes RA, et al. A novel sulfonamide derivative as a strong and selective apoptotic agent against hematological malignancies. Chem. Pap. 2020; 74:2965–2976.
Bigolin A, Maioral MF, Stefanes NM, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anticancer Drugs. 2020; 31(7):709-717.
Maioral MF, Stefanes NM, Neufeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC. Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med. Chem. 2020; 12(8):673–688.
Perondi DM, Jacques AV, Stefanes NM, Maioral MF, Sens L, Pacheco LA, Cury NM, et al. A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. Anticancer Drugs. 2019; 30(8):p 828-837.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Argenta DF, Dotto MER, Santos-Silva MC, et al. PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment. Eur. Polym. J. 2019; 119:335-343.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Santos-Silva MC, Nunes RJ, Parize AL, et al. A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity. Mater. Sci. Eng. C [Internet]. 2019; 105:110051.
Maioral MF, Stefanes NM, Bigolin A, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Miconidine acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest. New Drugs. 2019; 37:912–922.
Srefanes NM, Toigo J, Maioral MF, Jacques AV, Chiaradia-Delatorre LD, Perondi DM, Ribeiro AAB, et al. Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity. Bioorg. Med. Chem. 2019; 27(2):375-382.
Maioral MF, Bodack CN, Stefanes NM, Bigolin A, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochim. 2017; 140:48-57.
You can view some of Dr Natália’s work below and links to her professional profile below.
Research Gate: https://www.researchgate.net/profile/Natalia-Stephanes
Linkedin: https://www.linkedin.com/in/nataliamarceli/
Can you take Benadryl and Advil together?
Yes, you can take Benadryl (Diphenhydramine) and Advil (Ibuprofen) at the same time. The two medications do not interact with one another or cause similar side effects (1).
They are absolutely safe to use at the same time. The ideal time for taking Benadryl is nighttime because of its sedative nature. You can take Advil at that time too. People who are sensitive to the side effects of Advil can take Benadryl with Tylenol.
Potential benefits of taking Benadryl and Advil together
Taking Benadryl and Advil together may offer potential benefits for certain individuals experiencing multiple symptoms. These medications can provide a more comprehensive approach to managing certain conditions.
For example, if someone has an allergic reaction that causes both nasal congestion and body aches, the combination of Benadryl and Advil can address both the allergy symptoms and pain simultaneously (1,2).
However, these medications can cause side effects. Even though they are OTC, taking Benadryl and Advil together should still be done with caution and under the guidance of a healthcare provider.
While these medications can be safe when used appropriately, it’s crucial to consider individual factors such as medical history, current health conditions, and potential drug interactions.
Following the recommended dosages and using them for short-term relief is generally safe for most people. However, using them together for an extended period or in high doses without medical supervision can increase the risk of side effects and potential harm to your health.
Benadryl can also be used with other anti-inflammatory medications, such as corticosteroids like Prednisone.
Who should not take Benadryl and Advil together?
Individuals who should not take Benadryl and Advil together include those who have known allergies or hypersensitivity to these medications or their active ingredients (1,2). If you have experienced an allergic reaction to either Benadryl or Advil in the past, it is essential to avoid taking them together.
People with a history of stomach ulcers, gastrointestinal bleeding, or other digestive issues should also use caution when considering the combination of Benadryl and Advil, especially Advil (3).
Individuals with a history of kidney or liver problems should consult their healthcare provider before taking Benadryl and Advil together. These medications can affect kidney and liver function, and using them in combination may increase the risk of adverse effects (1,2).
Pregnant and breastfeeding individuals should also seek medical advice before using Benadryl and Advil together. It’s essential to weigh the potential risks and benefits, as these medications may have implications during pregnancy and lactation (1,2).
Benadryl is not considered suitable to be used in all age groups. The geriatric or elderly population should not use Benadryl because of its mind-numbing and sedative properties.
There are other antihistamines, usually non-sedative, that are more suitable to use for such people. The use of Benadryl should also be avoided in Children and should only be given when prescribed by the healthcare provider.
People who are on other prescription medications that can affect sleep, like Benzodiazepines, should not take Benadryl. It’s best to talk to your doctor or pharmacist before combining Benadryl with any prescription medication.
If you are currently taking other medications, including prescription, over-the-counter, or herbal supplements, it’s crucial to inform your healthcare provider. Some medications can interact with Benadryl and Advil, affecting their efficacy or increasing the risk of side effects.
Always consult your healthcare provider before combining medications, and follow their guidance to ensure safe and appropriate use based on your individual health status and medical history.
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References
1.-
Sicari V, Zabbo CP. Diphenhydramine. 2022 Jul 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30252266. https://www.ncbi.nlm.nih.gov/books/NBK526010
2.-
Ngo VTH, Bajaj T. Ibuprofen. 2023 May 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31194439. https://www.ncbi.nlm.nih.gov/books/NBK542299
3.-
Pellicano R. Gastrointestinal damage by non-steroidal anti-inflammatory drugs: updated clinical considerations. Minerva Gastroenterol Dietol. 2014 Dec;60(4):255-61. PMID: 25384803. https://pubmed.ncbi.nlm.nih.gov/25384803/
