Can you take Benadryl with Prednisone?
By
Dr Drielli Vital-Fujii (PhD)
Author bio
Dr Drielli Vital-Fujii, PhD, is a Pharmacist with expertise in Drug Design and Development, Enzymes, Molecular Modelling, and Photodynamic Therapy. She writes and reviews content on these topics.
Dr Drielli Vital-Fujii’s Highlights:
- Postdoctoral fellow at the Department of Biochemistry at the University of São Paulo, emphasizing therapy of neglected diseases using light.
- PhD in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Six months as an international researcher at the Center for Discovery and Innovation in Parasitic Diseases (University of California San Diego)
- Master’s degree in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Bachelor of Pharmacy at the University of Mogi das Cruzes – São Paulo / Brazil
Professional Experience:
2012 – 2018 Project manager at University of São Paulo – Pharmacy Department
Dr Drielli Vital-Fujii has worked with computational studies, synthesis, biological evaluation, design, and development of new inhibitor candidates for Chagas Disease and Leishmaniasis.
2017 – 2017 International research fellow at University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences – Center for Discovery and Innovation in Parasitic Diseases.
She used Virtual Screening (VS) and High-Throughput Screening (HTS) Integration in the Discovery of new drugs against neglected tropical diseases (NTDs).
2018 – 2019 Faculdades Oswaldo Cruz
Dr Drielli Vital-Fujii was a professor in the Faculty of Pharmacy, teaching the subjects of Pharmaceutical Chemistry and Drug Development.
2019 – 2021 Researcher in Biochemistry University of São Paulo – Biochemistry Department
She applied Photodynamic Therapy in Leishmaniasis Treatment, mentored undergraduate students in scientific activities, and wrote, executed, translated, and reported scientific projects with funding agencies.
2023-2023 UniPiaget – University Center.
Dr Drielli Vital-Fujii was a Biology, Nutrition, Physiotherapy, and Pharmacy professor.
Education:
2018 -2021 Postdoctoral at the Department of Biochemistry at the University of São Paulo
2013 -2018 PhD of Science: Drugs and Medicines at Department of Pharmacy at University of São Paulo
2012 -2013 M.Sc. of Sciences: Drugs and Medicines at the Department of Pharmacy at the University of São Paulo
2005-2008 Bachelor of Pharmacy at the University of Mogi das Cruzes
The leading publications of Dr Drielli Vital-Fujii are:
Vital-Fujii, D.G, Baptista, M.S. (2021). Progress in the photodynamic therapy treatment of Leishmaniasis. Brazilian Journal of Medical and Biological Research, 54, 1-11.
Gatti, F. M., Gomes, R.A., da Fonseca, A.L., Lima, E.J.C., Vital-Fujii, D.G., Taranto, A.G., Varotti, F.P., Trossini, G.H.G. (2020). Antiplasmodial activity of sulfonylhydrazones: in vitro and in silico approaches. Future medicinal chemistry, 13, 233-250.
Silva, E.J., Bezerra-Souza, A., Passero, L.F., Laurenti, M.D., Ferreira, G.M., Fujii, D.G.V., et al. (2018). Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives. Future medicinal chemistry, 10, 2069-2085.
Leite, F.H.A., Froes, T.Q., da Silva, S.G., de Souza, E.I.M., Vital-Fuji,i D.G., Trossini, G.H.G., et al. (2017). An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. European Journal of Medicinal Chemistry, 132, 322-332.
Vital, D.G., Damasceno, F.S., Rapado, L.N., Silber, A.M., Vilella, F.S., Ferreira, R.S., et al. (2017). Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study. Journal of Biomolecular Structure and Dynamics, 35, 1244–1259.
Mello, J. F.R., Gomes, R.A., Vital-Fujii, D.G., Ferreira, G.M., Trossini, G.H.G. (2017). Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases. Chemical Biology & Drug Design, 90, 1067-1078.
Pantaleao, S.Q., Fujii, D.G.V., Maltarollo, V.G., da C. Silva, D., Trossini, G.H.G., Weber, K.C., et al. (2017). The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery. Medicinal Chemistry, 13, 706-720.
Vital, D., Arribas, M., Trossini, G. (2014). Molecular Modeling and Docking Application to Evaluate Cruzain Inhibitory Activity by Chalcones and Hydrazides. Letters in Drug Design and Discovery, 11, 249-255.
Blau, L., Menegon, R.F., Trossini, G.H.G., Molino, J.V.D., Vital, D.G., Cicarelli, R.M.B., et al. (2013). Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates. European Journal of Medicinal Chemistry, 67, 142-151.
You can view some of Dr Drielli’s work below and links to her professional profile.
Orcid: https://orcid.org/0000-0001-9270-0466
Research Gate: https://www.researchgate.net/profile/Drielli-Gomes-Vital-Fujii
Scopus: https://www.scopus.com/authid/detail.uri?authorId=55829534000
Google Scholar: https://scholar.google.com/citations?user=F9U50AEAAAAJ&hl=pt-BR
Linkedin: linkedin.com/in/driellivital
Escavador: https://www.escavador.com/sobre/6101380/drielli-gomes-vital
CDIPD: https://cdipd.org/index.php/about-us/visiting-scientists
Can you take Benadryl with Prednisone?
Yes, you can take Benadryl and Prednisone together. There is no known interaction between the two medications; they can be taken safely and concomitantly (1,2).
Benadryl is a first-generation antihistamine medication that is used for the management and treatment of allergy symptoms and it helps you fall asleep. Prednisone, on the other hand, is a Corticosteroid.
It is well known for its anti-inflammatory properties and it can also be used in certain allergic reactions. Although it is entirely safe to use these two together, it’s not recommended to take them excessively.
Potential benefits and risks of taking Benadryl with Prednisone
Taking Benadryl (Diphenhydramine) with Prednisone can have both potential benefits and risks (1,2).
Potential Benefits
- Enhanced allergy relief: Benadryl is an antihistamine that can help relieve allergy symptoms like sneezing, runny nose, itching, and watery eyes. When combined with Prednisone, which is a corticosteroid, it may provide more effective relief from severe allergic reactions or inflammation.
Potential Risks
- Drug interaction: Combining these medications can lead to drug interactions, affecting how each medication works in the body. It’s important to consult a healthcare professional to ensure they are safe to use together, especially if you’re taking other medications or have certain medical conditions.
- Increased side effects: Taking Benadryl and Prednisone together may increase the risk of side effects, such as dizziness, tiredness, dry mouth, blurred vision, or heart palpitations. Monitoring for any unusual symptoms and seeking medical attention if they occur is crucial.
- Worsening health conditions: While Prednisone can help manage various inflammatory conditions, using it with Benadryl may not always be suitable for everyone. It could mask certain symptoms or lead to complications in some medical conditions.
How to ensure the safe and effective use of Benadryl with Prednisone?
The following points are important to ensure the safe and effective use of Benadryl with Prednisone (1,2):
- Follow the prescribed dosages of both medications as directed by your healthcare provider.
- Inform your doctor about any existing medical conditions, allergies, or other medications you’re taking.
- Take Benadryl and Prednisone at separate times, unless your doctor advises otherwise.
- Be aware of potential side effects, especially drowsiness, and avoid activities that require alertness until you know how the medications affect you.
- Avoid alcohol or other sedating substances while using these medications.
- Monitor for any unusual symptoms or reactions and seek medical attention if needed.
- Do not stop or adjust the dosage of either medication without consulting your doctor.
- Follow your healthcare provider’s advice on the duration of treatment with these medications.
- Store the medications properly, following their specific storage instructions.
- If you experience any new or worsening symptoms, consult your doctor promptly.
Final words
To sum up, Benadryl and Prednisone can be taken together, but it’s best to talk to your doctor about it first. Some people might have underlying health conditions or other health-related factors that could potentially contribute to adverse events. This is why professional advice from your healthcare provider is important.
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References
1.-
Sicari V, Zabbo CP. Diphenhydramine. 2022 Jul 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30252266. https://www.ncbi.nlm.nih.gov/books/NBK526010
2.-
Puckett Y, Gabbar A, Bokhari AA. Prednisone. 2023 Mar 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30521230. https://www.ncbi.nlm.nih.gov/books/NBK534809
