Can you drink coffee while taking Naproxen? 

Can you drink coffee while taking Naproxen? 

You can drink coffee while you’re taking Naproxen, but it’s best to space them out and not take them at the exact same time. 

Naproxen is one of the most commonly used NSAIDs and is quite effective at what it does, but it can cause some side effects which may be enhanced if you drink coffee along with it. 

This is why most doctors recommend having an adequate time gap between these two. This allows you to safely enjoy coffee while taking Naproxen. 

Does coffee affect the absorption of Naproxen? 

According to several research studies, caffeine does affect the absorption of Naproxen or NSAIDs in general and increases the bioavailability of these painkillers. 

This does increase the analgesic and anti-inflammatory effects of these meds but can also increase the risk of side effects(1)

There are some combination NSAIDs – like fixed-dose Aspirin, Acetaminophen, and caffeine – which are used for greater pain relief, especially for migraines(2)

However, the risk-benefit ratio of the combined use of Caffeine and NSAIDs can vary from person to person. A healthy individual may gain some benefits if the doses are adjusted and are within the safety window. 

However, people who have an underlying gastrointestinal illness can’t possibly take this combination because of the additive gastrointestinal adverse events. 

Some NSAIDs may be combined with caffeine to help increase their activity, such as Aspirin Back & Body manufactured by Bayer Pharmaceuticals, which also contains caffeine. However, it is important to note that such formulations do not work well for everyone.

What are the potential risks of combining Naproxen and coffee? 

Naproxen is an NSAID, which is commonly associated with a number of side effects that may hit you more prominently if you take coffee at the exact same time as you take Naproxen. 

It usually happens because coffee can increase the absorption of Naproxen, which may increase the side effects or Coffee can cause side effects somewhat similar to Naproxen, and the two can cause additive side effects. Commonly expected side effects are:

  • Nausea 
  • Vomiting
  • Diarrhoea 
  • Flatulence 
  • Acid reflux 
  • Abdominal pain 
  • Anxiety 
  • Lightheadedness

Coffee and Naproxen may also significantly increase the risk of:

  • Gastrointestinal bleeding 
  • Ulceration 
  • Stomach or intestinal perforation 

This is why it’s best to space these two out. You can take these two on the same day as long as you have an adequate time gap in between. 

Alternatives to Naproxen for pain relief 

There are other OTC alternatives to Naproxen for pain relief, one of which is considered the safest. Acetaminophen is one of the safest OTC painkillers that you can combine with coffee and other medications as well. 

The only concern with Acetaminophen is liver damage, which is not common at standard therapeutic doses. Since Acetaminophen has a wide safety window, a very high dose of this painkiller is considered harmful to your liver, and not a therapeutic dose. 

However, you should consult your doctor if you already have liver disease or your pain is too severe for Acetaminophen to control. 

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Granados-Soto V, Castañeda-Hernández G. A review of the pharmacokinetic and pharmacodynamic factors in the potentiation of the antinociceptive effect of nonsteroidal anti-inflammatory drugs by caffeine. J Pharmacol Toxicol Methods. 1999 Oct;42(2):67-72. doi: 10.1016/s1056-8719(00)00044-7. PMID: 10924888. Available from:


Lipton RB, Stewart WF, Ryan RE Jr, Saper J, Silberstein S, Sheftell F. Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain: three double-blind, randomized, placebo-controlled trials. Arch Neurol. 1998 Feb;55(2):210-7. doi: 10.1001/archneur.55.2.210. PMID: 9482363. Available from: