Can Fluvoxamine mess with your periods? (+3 factors)

In this article, we will discuss the effects of Fluvoxamine on periods or menstrual health. We will also discuss some research studies and what one should do if this side effect occurs.

Can Fluvoxamine mess with your periods?

Fluvoxamine may affect periods in some women. Although it is not considered a common side effect, menstrual irregularities are considered possible and listed as a side effect of Fluvoxamine.

Menstrual problems such as heavy or unusual bleeding, spotting or bleeding between periods, and periods with severe pain and cramps can be caused by the use of some antidepressants such as Fluvoxamine (1)

According to the National Health Service, these changes are not normal and should be discussed with a healthcare provider immediately.

Fluvoxamine, a selective serotonin reuptake inhibitor, is an antidepressant used for treating anxiety and depression (2).

Several studies have shown that Fluvoxamine and other antidepressants like Sertraline, Fluoxetine, Citalopram, Mirtazapine, Venlafaxine etc cause menstruation disorders.

What is the potential connection between Fluvoxamine and irregular periods?

Antidepressants such as Fluvoxamine can interfere with menstrual cycles leading to irregular periods. Fluvoxamine, which is an SSRI, can cause the release of high levels of a hormone called prolactin.

Elevated prolactin levels prevent the ovaries from releasing eggs by blocking the release of follicular-stimulating hormone (FSH), leading to missed periods (5).

What does research suggest?

Several research studies have found a link between menstrual issues and Fluvoxamine or antidepressants in general. 

One of the research studies was conducted on 1432 women subjects. They were divided into two groups, the antidepressant group and the control group. The results showed that menstrual disorders were high in the antidepressant group (3)

Another study indicated a notable prevalence of menstruation disorders among women using antidepressants, suggesting a potential association between such disorders and the use of antidepressant medications (4).

Can Fluvoxamine lead to other hormonal changes?

Fluvoxamine, being an SSRI, mainly targets serotonin, a neurotransmitter, in the brain. However, it can indirectly influence changes in the secretion of some hormones like cortisol and prolactin and possibly others. The extent of changes can vary among individuals.

The impact of Fluvoxamine on these hormone levels is less significant compared to other medications that directly affect hormone regulation. If you are concerned about hormone changes while taking Fluvoxamine, it is important to consult this with your healthcare provider.

What other factors besides Fluvoxamine lead to irregular periods? 

Various factors can contribute to irregular periods. These include:

  • Pregnancy
  • Stress and anxiety
  • Hormone imbalance e.g elevated levels of prolactin hormone
  • Certain infections e.g uterine fibroids and endometrial polyps
  • Trauma
  • Weight changes
  • Certain medications e.g antiepileptics and antidepressants
  • Age
  • Menopause
  • Intrauterine devices (IUD)

Can depression affect your period?

Depression or high levels of stress can affect your menstrual cycles. Various studies have suggested that women suffering from depression are more prone to irregular periods.

Depression triggers cortisol release affecting the hypothalamus. This affects the usual signal from the hypothalamus to release an egg, resulting in delayed or absent periods due to altered ovulation (6).

If your period becomes irregular or problematic while taking Fluvoxamine, it could be a sign that the medication is not effectively managing your depression. In such cases, it is important to discuss this with your healthcare provider.

What to do if Fluvoxamine is affecting your period?

If Fluvoxamine is affecting your periods, reach out to your healthcare provider. Your doctor may try a dose reduction at first to help your body adjust to the medication. If dose reduction does not work, they may gradually discontinue the medication or switch to another antidepressant with fewer side effects.

Additionally, your doctor may recommend hormonal assays to check the levels of hormones in your body, like prolactin, to diagnose any potential hormonal changes that could affect your menstrual cycle.

It is all about finding the best strategy to help you feel your best, both mentally and physically. So, communicate openly with your healthcare provider.

Alternative medications if Fluvoxamine is affecting your periods

If you are experiencing irregular periods while taking Fluvoxamine, your doctor may switch to another antidepressant such as:

  • Sertraline 
  • Paroxetine  
  • Bupropion

However, it is crucial to remember that these medications have their own side effects and individual responses to medications vary. So, it is important to consult your doctor before switching to another antidepressant. They can provide guidance based on your individual health and needs.


In my opinion, Fluvoxamine can cause irregular periods in some women. However, individual responses to medications vary. It is advisable to communicate openly with your healthcare provider for personalized guidance and treatment plans.



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