Can Cymbalta increase your blood pressure? (+5 factors)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss the research findings linking Cymbalta and hypertension. We will also explore some factors that may increase the risk of elevated blood pressure with Cymbalta use. Additionally, we will explore the alternatives to Cymbalta if it causes high blood pressure.
Can Cymbalta increase your blood pressure?
Yes, Cymbalta can increase your blood pressure. Individuals with pre-existing cardiovascular conditions or those at risk for changes in blood pressure should be closely monitored while taking Cymbalta. As with any medication, the benefits and risks should be carefully weighed based on an individual’s health and medical history.
Cymbalta is an antidepressant medication that is most frequently prescribed for the management of various disorders such as anxiety, depression, and fibromyalgia. Like any other medication, Cymbalta can also cause different side effects in individuals including high blood pressure, dry mouth, headache, nausea, vomiting, and dizziness (1).
What does research suggest?
According to research, the use of Cymbalta is associated with increased blood pressure, heart rate, and pulse rate, along with other cardiovascular effects. A research study demonstrated that the use of this medication is associated with a notable increase in blood pressure at a dosage of 60mg daily for 2 weeks (2).
In another research study, Cymbalta used for the management of fibromyalgia, showed potential cardiovascular side effects. Specifically, a reported case documented high blood pressure after starting Cymbalta, which promptly resolved after stopping the medication (3).
Another study found that a patient with underlying diabetes experienced a hypertensive crisis after taking Cymbalta for one day. The increased blood pressure was successfully managed by using beta-blocker antihypertensive medications. This case suggests the need for careful monitoring and management when initiating Cymbalta treatment (4).
What factors can influence Cymbalta-induced high blood pressure?
There are several factors that could increase the risk of hypertension when taking Cymbalta such as:
Pre-existing Hypertension: People with a history of hypertension or those predisposed to high blood pressure might be more susceptible to an increased risk.
Dosage: Higher doses of Cymbalta may be associated with a higher chance of elevating blood pressure. It’s important to take the medication as prescribed by a healthcare professional.
Sensitivity to Cymbalta: Individual sensitivity to medications including Cymbalta can vary among people. Some individuals might be more vulnerable to changes in blood pressure as a response to Cymbalta.
Physical factors: Age, obesity, and overall health of individuals make them more vulnerable to changes in blood pressure. Close monitoring is particularly important in these elderly populations.
Unhealthy diet: An unhealthy diet, use of alcohol, and cigarette smoking are the risk factors for high blood pressure. When combined with the effects of Cymbalta, these factors may pose an additional risk.
What to do if Cymbalta increases your blood pressure?
If you experience increased blood pressure after taking Cymbalta, it’s essential to communicate promptly with your healthcare provider. Open communication with your healthcare providers about the medical history, existing health conditions, and any concerns about potential side effects, including changes in blood pressure is necessary to effectively manage your condition.
Your healthcare provider may conduct a thorough assessment to determine the cause of increased blood pressure. If Cymbalta is associated with your increased blood pressure, regular monitoring and adjustments to the treatment plan can help manage your blood pressure effectively.
Adopting a healthy lifestyle can positively impact your blood pressure. This may include changes in diet (such as reducing sodium intake), regular exercise, weight management, and minimizing alcohol and caffeine consumption.
What are alternatives to Cymbalta if it causes high blood pressure?
If you’re experiencing increased blood pressure as a side effect of Cymbalta, it’s important to consult your doctor. They can evaluate your overall health, consider alternative medications, or adjust your treatment plan as needed.
Possible alternatives to Cymbalta for managing conditions like depression, anxiety, or other mental disorders may include, selective serotonin reuptake inhibitors such as fluvoxamine, or other serotonin-norepinephrine reuptake inhibitors such as Pristiq, and Savella which are less likely to elevate your blood pressure.
Your healthcare provider will consider various factors, such as your medical history, the specific condition being treated, and potential side effects when determining the most appropriate alternative.
In my opinion, Cymbalta may contribute to elevated blood pressure in certain individuals. However, recognizing the variability in individual responses to medications, it is crucial for patients to communicate any observed side effects, including changes in blood pressure, to their healthcare providers.
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References
1.-
Dhaliwal JS, Spurling BC, Molla M. Duloxetine. 2023 May 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31747213. https://pubmed.ncbi.nlm.nih.gov/31747213/
2.-
Derby MA, Zhang L, Chappell JC, Gonzales CR, Callaghan JT, Leibowitz M, Ereshefsky L, Hoelscher D, Leese PT, Mitchell MI. The effects of supratherapeutic doses of duloxetine on blood pressure and pulse rate. J Cardiovasc Pharmacol. 2007 Jun;49(6):384-93. doi: 10.1097/FJC.0b013e31804d1cce. PMID: 17577103. https://pubmed.ncbi.nlm.nih.gov/17577103/
3.-
Mermi O, Atmaca M. Duloksetin Kullanımına Bağlı Hipertansiyon: Bir Olgu Sunumu [Duloxetine-Induced Hypertension: A Case Report]. Turk Psikiyatri Derg. 2016 Spring;27(1):67-9. Turkish. PMID: 27369688. https://pubmed.ncbi.nlm.nih.gov/27369688/
4.-
Shukla R, Khasbage S, Garg MK, Singh S. Duloxetine-induced hypertensive urgency in type 2 diabetes mellitus with diabetic neuropathy. Indian J Pharmacol. 2020 May-Jun;52(3):213-215. doi: 10.4103/ijp.IJP_370_19. Epub 2020 Aug 4. PMID: 32874005; PMCID: PMC7446681. https://pubmed.ncbi.nlm.nih.gov/32874005/
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