Can Cephalexin raise blood pressure? 

Can Cephalexin raise blood pressure? 

No, Cephalexin is not associated with high blood pressure as a side effect. It was not reported in any of the clinical trials or research studies.

Cephalexin is an antibiotic commonly utilized to combat conditions such as respiratory tract infections, including throat infections, bronchitis, sinus infections, and pneumonia

However, Cephalexin being an antibiotic can affect your blood pressure if you’re taking it concomitantly with other medications. (1)

Drug interactions are sometimes neglected, but they can make a huge difference in the therapeutic response you achieve. 

It’s best to ask your healthcare provider if there’s even the slightest possibility of an interaction between your antibiotic and other prescription or OTC medications that you have been taking lately. 

Apart from this, drug-disease interactions are also considerable. Studies have indicated that people who have severe hypertension may respond negatively to Cephalexin or other antibiotics. In general, antibiotics like Cephalexin, Azithromycin, etc don’t increase blood pressure. 

This interaction sure isn’t common, but as I said, it’s considerable. Make sure you talk to your doctor about this and do not make any changes in your dose or frequency of drug administration without your doctor’s approval. 

What side effects are common with Cephalexin use?

Cephalexin, although it does not increase blood pressure, can cause some side effects. These include: (2)

Common side effects of cephalexin may include

  • Upset stomach or gastrointestinal discomfort
  • Diarrhoea
  • Nausea
  • Vomiting
  • Abdominal pain or cramps
  • Headache
  • Dizziness
  • Fatigue or tiredness
  • Skin rash or itching

Rare side effects of cephalexin may include:

  • Allergic reactions, such as hives, swelling, or difficulty breathing
  • Severe diarrhoea or persistent watery stools
  • Yellowing of the skin or eyes (jaundice)
  • Dark urine
  • Easy bruising or bleeding
  • Unusual tiredness or weakness
  • Joint pain or swelling
  • Seizures
  • Changes in mood or mental state

What to do if your blood pressure is getting high while taking Cephalexin?

If you notice that your blood pressure is increasing while taking cephalexin, it is important to consult your healthcare provider. They will evaluate your situation and determine the best course of action. 

They may recommend adjusting the dosage of cephalexin or switching to a different medication if necessary. It’s crucial not to make any changes to your medication regimen without medical guidance. 

Your healthcare provider will monitor your blood pressure and provide appropriate guidance to ensure your safety and well-being.

Make sure you take Cephalexin properly to make the most out of it. Always check for the expiry date before you take your meds, as expired meds won’t help you with your symptoms adequately.

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Speight TM, Brogden RN, Avery GS. Cephalexin: a review of its antibacterial, pharmacological and therapeutic properties. Drugs. 1972;3(1):9-78. doi: 10.2165/00003495-197203010-00002. PMID: 4559812.


Herman TF, Hashmi MF. Cephalexin. 2022 Aug 18. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31747187.