Can Adderall cause Lupus? (11 Identification Features)
By
Dr Natalia Marceli Stephanes (PhD)
Author bio
Dr Natália Marcéli Stephanes PhD is a Pharmacist with expertise in Drugs Administration and Toxicity; Discovery of New Drugs; Cancer Treatment; Biochemical Analyzes and Hematological Analyzes. She writes and reviews content on these topics.
Dr Natália Marcéli Stephanes’ Highlights:
- Pharmacist at the Department of Health of Santa Catarina State, Brazil
- PhD with a focus on oncology treatment
- Years of experience in commercial pharmacy
- Bachelor, Master and PhD degrees in Pharmacy at the Federal University of Santa Catarina
Professional Experience:
From her undergraduate studies to her Master’s and Doctorate degrees in Pharmacy, Dr Natália Marcéli Stephanes has participated in numerous scientific studies in the field of oncology and onco-hematology at the University Hospital of the Federal University of Santa Catarina, Brazil. Her research has focused on understanding the molecular and biochemical bases of malignant neoplasms and investigating safer and more effective therapeutic alternatives.
Dr Natália Marcéli Stephanes has also served as an assistant professor of haematology for undergraduate students at the Federal University of Santa Catarina. Additionally, she held the position of professor of Hospital Pharmacy at the Qualificar Technical School in Brazil, where she developed instructional materials for use in the Pharmacy Postgraduate Program at the Leonardo Da Vinci University Center.
In addition to her academic experiences, Dr Natália Marcéli Stephanes possesses a strong expertise in commercial pharmacy, with in-depth knowledge of medications, their routes of administration, desired effects, adverse effects, and toxicity.
Currently, Dr Natália Marcéli Stephanes works as a Pharmacist at the Health Department of Santa Catarina State, where her role entails providing pharmaceutical scientific consulting services to judges.
Education:
- 2016 Bachelor in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2018 Master in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2023 PhD in Pharmacy at the Federal University of Santa Catarina, Brazil
The main publications of Dr Natália Marcéli Stephanes are:
Falchetti M ; Delgobo M, Zancanaro H, Almeida K, Das Neves RN, Dos Santos B, Stefanes NM, et al. Bishop Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Comput. Biol. Med [Internet]. 2023; 152:106347.
Feuser PM, Matos dos Santos PC, Cordeiro AP, Stefanes NM, Walter LO, Maioral MF, Santos-Silva MC, et al. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562). J Drug Deliv Sci Technol [Internet]. 2022; 67:102924.
Jacques AV, Stefanes NM, Walter LO, Perondi DM, Efe FL, Souza LFS, Sens L, et al. Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines. Bioorg. Chem [Internet]. 2021; 116:105315.
Duarte BF, Vieira DSC, Lisboa ML, Stefanes NM, Grando LJ, Santos-Silva MC. Características clínico-epidemiológicas de pacientes portadores de carcinoma de células escamosas de boca. Arquivos Catarinenses de Medicina. 2021; 50(2): 232–245.
Machado V, Jacques AV, Stefanes NM, Santos-Silva MC, Biavatti MW. Anti-leukemic activity of semisynthetic derivatives of Lupeol. Nat. Prod. Res. 2021; 35(22):4494-4501.
Bigolin A, Maioral MF, Stefanes NM, Mascarello A, Chiaradia-Delatorre LD, Nunes RJ, Yunes RA, et al. A novel sulfonamide derivative as a strong and selective apoptotic agent against hematological malignancies. Chem. Pap. 2020; 74:2965–2976.
Bigolin A, Maioral MF, Stefanes NM, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anticancer Drugs. 2020; 31(7):709-717.
Maioral MF, Stefanes NM, Neufeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC. Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med. Chem. 2020; 12(8):673–688.
Perondi DM, Jacques AV, Stefanes NM, Maioral MF, Sens L, Pacheco LA, Cury NM, et al. A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. Anticancer Drugs. 2019; 30(8):p 828-837.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Argenta DF, Dotto MER, Santos-Silva MC, et al. PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment. Eur. Polym. J. 2019; 119:335-343.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Santos-Silva MC, Nunes RJ, Parize AL, et al. A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity. Mater. Sci. Eng. C [Internet]. 2019; 105:110051.
Maioral MF, Stefanes NM, Bigolin A, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Miconidine acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest. New Drugs. 2019; 37:912–922.
Srefanes NM, Toigo J, Maioral MF, Jacques AV, Chiaradia-Delatorre LD, Perondi DM, Ribeiro AAB, et al. Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity. Bioorg. Med. Chem. 2019; 27(2):375-382.
Maioral MF, Bodack CN, Stefanes NM, Bigolin A, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochim. 2017; 140:48-57.
You can view some of Dr Natália’s work below and links to her professional profile below.
Research Gate: https://www.researchgate.net/profile/Natalia-Stephanes
Linkedin: https://www.linkedin.com/in/nataliamarceli/
Can Adderall cause Lupus?
No, There is no definitive evidence to suggest that Adderall directly causes lupus. Lupus is an autoimmune disease that occurs when the immune system mistakenly attacks healthy tissues in the body.
The exact cause of lupus is not fully understood, but it is believed to involve a combination of genetic and environmental factors.
Adderall is a prescription medication that contains Amphetamine and Dextroamphetamine, which are stimulant drugs used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.
While Adderall can have side effects, such as increased heart rate, elevated blood pressure, increased urination and changes in mood or behaviour, it has not been identified as a direct cause of lupus. (1)
However, it is essential to note that any concerns about developing or worsening lupus symptoms should be discussed with a healthcare professional. They can provide personalized guidance based on individual medical history and specific circumstances.
How to know if you have Lupus?
Lupus, or systemic lupus erythematosus (SLE), is a complex autoimmune disease affecting various body parts. It can be challenging to diagnose because its symptoms can mimic those of other conditions. If you experience any of the following signs or symptoms, it is advisable to consult a healthcare professional for a proper evaluation: (2)
- Fatigue: Persistent and unexplained fatigue or exhaustion, even after adequate rest.
- Joint pain and swelling: Recurrent joint pain, stiffness, and swelling, commonly affecting the fingers, hands, wrists, and knees.
- Skin rashes: A characteristic butterfly-shaped rash across the cheeks and bridge of the nose, often worsened by sun exposure. Other skin problems like rashes on other body parts, sensitivity to sunlight, and sores in the mouth or nose may also occur.
- Fever: Unexplained fever, usually low-grade but occasionally high-grade.
- Sensitivity to sunlight: Increased sensitivity to sunlight, resulting in rashes or flares of existing skin symptoms.
- Hair loss: Patchy hair loss or thinning, often accompanied by scalp tenderness.
- Raynaud’s phenomenon: Fingers and toes becoming pale, numb, and cold in response to cold temperatures or stress.
- Chest pain: Chest discomfort or pain, especially when taking a deep breath, and shortness of breath.
- Kidney problems: Symptoms may include increased urination, blood in the urine, or swelling in the legs and ankles.
- Mouth or nose ulcers: Painful sores or ulcers in the mouth or nose that do not heal quickly.
- Other symptoms: These can include swollen glands, unexplained weight loss, headaches, vision changes, memory problems, and gastrointestinal issues.
Remember that these symptoms can vary from person to person, and not everyone with lupus will experience all of them. Additionally, other medical conditions can also cause similar symptoms. Therefore, it is crucial to consult a healthcare professional for an accurate diagnosis.
How is Lupus treated?
The treatment for lupus (systemic lupus erythematosus or SLE) depends on the severity of symptoms and the organs affected. While there is no cure for lupus, the primary goals of treatment are to control symptoms, prevent organ damage, and minimize flare-ups.
The treatment plan is typically tailored to each individual’s needs and may involve a combination of the following approaches: (2)
Medications:
Various medications can be prescribed to manage different aspects of lupus, including:
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Help reduce pain, swelling, and inflammation.
- Antimalarial drugs: Hydroxychloroquine or Chloroquine may be used to control skin rashes, joint pain, and fatigue.
- Corticosteroids: Prednisone or other steroids may be prescribed for severe symptoms or flare-ups to reduce inflammation and suppress the immune response.
- Immunosuppressants: Drugs such as Azathioprine, Methotrexate, Mycophenolate Mofetil, or Cyclophosphamide may suppress the overactive immune system.
- Biologics: These newer medications, such as Belimumab, specifically target immune system components involved in lupus.
Lifestyle modifications:
Healthy habits can help manage lupus symptoms and improve overall well-being. This may include:
- Sun protection: Limiting sun exposure, using sunscreen, and wearing protective clothing to minimize skin rashes and photosensitivity.
- Rest and stress management: Getting enough restful sleep and practising stress-reduction techniques can help manage fatigue and minimize flare-ups.
- Regular exercise: Engaging in low-impact activities, as advised by a healthcare professional, can help maintain joint flexibility, strengthen muscles, and improve overall fitness.
- Balanced diet: Eating a nutritious diet, including vegetables, fruits, whole grains, and lean proteins, can support overall health and help manage inflammation.
Monitoring and regular check-ups:
Regular medical follow-ups are essential to monitor disease activity, manage medications, and address emerging concerns or complications.
Supportive care:
Lupus can impact a person’s emotional well-being and quality of life. Seeking support from family, friends, or lupus support groups can provide valuable emotional support and information.
To develop a personalized treatment plan, working closely with a rheumatologist or healthcare professional experienced in treating lupus is essential. The treatment may be adjusted over time based on the individual’s response and disease activity.
Early diagnosis, prompt treatment, and ongoing management can help individuals with lupus lead productive lives and minimize the impact of the disease on their overall health.
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References
1.-
Dextroamphetamine and Amphetamine (National Library of Medicine, NIH)
2.-
Lupus: An Overview (National Library of Medicine, NIH)
