Can Adderall cause spotting between periods? (+3 factors)

 In this article, we’ll talk about how Adderall might affect menstrual cycles, especially if it causes spotting. We’ll look at research studies to understand if there’s a connection between using Adderall and changes in periods. Also, we will also discuss some management tips on what to do if you notice spotting issues with Adderall.

Can Adderall cause spotting between periods?

Yes, Adderall can cause spotting between periods. While this occurrence is not commonly reported as a side effect, individual responses to the medication can vary. Some individuals may experience unexpected reactions, and spotting has been noted as one of them.

Adderall, classified as a psychostimulant, is often prescribed for conditions like attention deficit hyperactivity disorder (ADHD) and narcolepsy. Despite its effectiveness in managing these conditions, it’s essential to approach its use with caution, especially for individuals with a history of cardiovascular disorders (1).

This precaution is vital to minimize potential side effects, such as elevated blood pressure, a rapid heart rate, insomnia, and heightened anxiety.

What does research suggest?

While the direct evidence linking Adderall to changes in menstrual patterns or spotting is limited, a growing number of case reports suggest a potential association with vaginal bleeding.

A comprehensive study encompassing over 47,000 individuals, who had been using Adderall for more than a year and encountered side effects, revealed intriguing findings.

Among the female participants, 0.2% reported experiencing vaginal bleeding between periods. Particularly noteworthy is the observation that spotting occurred more frequently among individuals below 30 who had been on the medication for 6 to 12 months (2).

Additionally, 10% of patients documented irregular periods following the use of Adderall, adding further nuance to the potential impact of the medication on menstrual health (2).

What factors may influence Adderall-induced irregular periods?

Several factors may increase the likelihood of experiencing irregular periods or spotting between periods while using Adderall. These factors may include (3):

Individual sensitivity Individual responses to medications vary, with some experiencing menstrual irregularities, including spotting, while others do not.
Concurrent medications Combining Adderall with medications like Wellbutrin, warfarin, and certain antipsychotics may increase the risk of irregular periods and spotting. 
Medical history Individuals with underlying medical conditions such as polycystic ovary syndrome (PCOS), fibroids, or thyroid disorders are more prone to experiencing these side effects when using Adderall. These conditions independently impact menstrual flow and contribute to spotting. The combination of Adderall with these existing conditions may further heighten the likelihood of spotting.

What to do if Adderall causes spotting between periods?

Consult your healthcare provider and provide detailed information about the spotting, including when it started, its frequency, and any other relevant details. Avoid making changes to your Adderall dosage or discontinuing it without consulting your healthcare provider.

Work with your healthcare team to explore alternative treatments or adjustments to your medication regimen if necessary. If there are underlying health conditions contributing to the spotting, discuss appropriate management strategies.

Undergo a thorough medical evaluation to identify the cause of the spotting. If Adderall is identified as a contributor, your healthcare provider may consider adjusting the dosage.

Review other medications you may be taking, as interactions can contribute to spotting. If there are underlying health conditions contributing to menstrual irregularities, your healthcare provider may recommend specific treatments based on your individual needs. 

How to manage Adderall-induced menstrual irregularities? 

Your healthcare provider may recommend various management strategies for addressing irregularities in your menstrual cycle, including spotting between periods.

  • Medications such as Tranexamic acid or progesterone therapy may be suggested to regulate your menstrual cycle.


  • Over-the-counter analgesics or NSAIDs can be provided to manage pain associated with irregular periods.


  • In some cases where Adderall influences menstrual cycles, hormonal treatments may be considered.


  • Lifestyle modifications, including maintaining a healthy diet, regular exercise, and stress alleviation, can positively influence menstrual regularity.


  • For underlying medical conditions like fibroids, your healthcare provider may recommend surgical interventions.

 In my opinion, the incidence of side effects such as menstrual irregularities with Adderall is relatively low. However, if you encounter any unexpected symptoms, including spotting between periods, after taking Adderall, it is advisable to promptly consult your healthcare provider. Seeking immediate guidance serves to avoid any complications and ensures the safety of your treatment.

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Fitzgerald KT, Bronstein AC. Adderall® (amphetamine-dextroamphetamine) toxicity. Top Companion Anim Med. 2013 Feb;28(1):2-7. doi: 10.1053/j.tcam.2013.03.002. PMID: 23796480.


Saei Ghare Naz M, Farahmand M, Dashti S, Ramezani Tehrani F. Factors Affecting Menstrual Cycle Developmental Trajectory in Adolescents: A Narrative Review. Int J Endocrinol Metab. 2022 Mar 2;20(1):e120438