Can Accutane cause haemorrhoids? (+3 treatments)

In this article, we will explore whether Accutane can be a cause of haemorrhoids or not, how can Accutane be linked to haemorrhoids, what factors might influence Accutane-induced haemorrhoids and what to do if Accutane causes haemorrhoids. 

Can Accutane cause haemorrhoids?

Yes, haemorrhoids can occur due to Accutane (isotretinoin). However, there is no definite causal link between Accutane and haemorrhoids but some indirect factors and pathways that Accutane is involved in might lead towards haemorrhoids. Accutane can be a causal factor that can contribute to the incidence of haemorrhoids. 

Accutane is the brand name of isotretinoin, a derivative of vitamin A. Accutane is used to treat acne by targeting the sebaceous glands by controlling the production of oil on the skin. The treatment with Accutane has a limited duration (1).

If you are taking Accutane for acne and have concerns regarding haemorrhoids or you experience any symptoms or signs of haemorrhoids then you should consult your healthcare provider. 

How can Accutane be linked to haemorrhoids?

Research studies have not determined any definite link between Accutane and haemorrhoids but there are some theories of the connection.

Accutane has been reported to trigger or exacerbate the condition of IBS (inflammatory bowel syndrome) particularly Crohn’s disease or ulcerative colitis (2). This condition can cause colon or rectum inflammation which may lead to haemorrhoids in some patients (3).

Dryness and constipation are a commonly reported side effect of Accutane. Constipation can cause complications due to straining during bowel movement. The hardened stool can further irritate the anal or rectal area leading towards haemorrhoids (4).

Not every person will experience haemorrhoids after taking Accutane as various individual factors are involved as well.

What factors can influence Accutane-induced haemorrhoids?

There are some indirect factors associated with Accutane that might influence the incidence or exacerbation of haemorrhoids. Here are a few of these factors:

• Dosage and duration are important as higher doses and longer durations of Accutane are more likely to cause haemorrhoids in patients.

• Dryness caused by Accutane can irritate the mucus membrane all over the body including the rectal and anal areas. This increased discomfort can cause an increased risk of haemorrhoids.

• Accutane can cause gastrointestinal issues like diarrhoea or constipation. Constipation can put a strain on the bowel movement which is potentially a cause of haemorrhoids.

• Accutane is also found to have caused dehydration in some individuals. Dehydration can lead to dryness which can indirectly increase the risk of haemorrhoids.

• Individual factors such as genetic predisposition, age, gender and metabolism also influence the incidence of haemorrhoids in patients taking Accutane.

• Certain interactions of Accutane as one with an underlying medical condition or concurrent medications can influence the incidence of haemorrhoids.

What to do if Accutane causes haemorrhoids?

If you experience haemorrhoids after taking Accutane then you should do the following (5):

• Consulting your healthcare provider is the most crucial step to be taken. Delaying the treatment can only worsen the condition and lead towards complications.

• Your doctor will perform a thorough analysis and might have to modify or alter your dosage regimen. They may lower the dose to reduce the intensity of side effects, particularly constipation and dryness.

• Your doctor will also prescribe some over-the-counter pain-relieving medications such as lidocaine or hydrocortisone to provide temporary relief from pain and discomfort. You may also be prescribed some NSAIDs such as naproxen.

• Warm baths with Epsom salt can also be helpful in providing temporary relief.

• If your condition is severe and the haemorrhoids are persistent then your doctor may suggest some treatment procedure such as sclerotherapy or rubber band litigation to shrink or remove haemorrhoids.

• Lifestyle modifications are also recommended such as boosting water uptake, taking high-fibre content in food and completing all the nutrient requirements.

If Accutane is found to be the cause of haemorrhoids then you might be asked to discontinue the medication and your doctor might any other alternative treatment for your acne to ensure safe and effective treatment with minimal side effects. The alternatives may include topical antibiotics such as:

• Erythromycin
• Clindamycin 
• Muciprocin

In my opinion, Accutane does not directly cause haemorrhoids in patients taking it for acne treatment. However, some of the side effects associated with Accutane can add up to or lead the patient towards haemorrhoids. These side effects are dryness and constipation.

The major cause of haemorrhoids is the strain during bowel movements especially during constipation. If you experience any symptoms or have any queries regarding the use of Accutane then it is better to consult your healthcare provider.

References