Are Vagifem and yuvafem the same? (+5 differences)

In this article, we will discuss Vagifem and yuvafem. We will discuss the differences and similarities between these two. Furthermore, we will discuss the ways to select the best among them based on your condition.

Are Vagifem and yuvafem the same?

Yes, Vagifem and yuvafem are the same medications. Yuvefem is the generic medication whereas, Vagifem is the brand drug of yuvafem. Both these medications have the same active ingredient.

Vagifem (yuvafem) is an estradiol which is used to treat vulvovaginal atrophy, a condition that occurs after menopause. It is used to treat vaginal itching, burning, and dryness due to menopause (1).

Vulvovaginal atrophy (VVA) is an inflammation of the vaginal epithelium due to reduced levels of estrogen. The only approved treatment for this condition is the administration of exogenous estrogen (2).

For this purpose, estrogen therapy can be given via many formulations such as estradiol vaginal creams, patches, inserts, or Vagifem (yuvafem) tablets (2).

However, always take Vagifem (yuvafem) with your doctor’s prescription. Vagifem and yuvafem share the same active ingredient however, there may be a few similarities and differences between the two.

What are some similarities and differences between Vagifem and yuvafem?

The following are the main similarities and differences between Vagifem and yuvafem (1):

The main difference between the Vagifem and yuvafem is their status. Vagifem is manufactured under a brand hence, it is more costly than the generic yuvafem tablets. Discuss with your healthcare provider and then start taking either of these medications.

How is Vagifem (yuvafem) vaginal tablet used?

Vagifem and yuvafem both are available in the form of vaginal tablets. The most appropriate way of using a vaginal tablet is as follows (1):

• The first step is to open the plastic wrap and remove the applicator.
• Choose a comfortable position, either one leg up on a chair or lie down.
• Hold the applicator in one hand with a finger on the end of the plunger.
• Use the other hand to guide the applicator inside the vaginal opening.
• Insert the applicator inside the vagina, as far as it is comfortable.
• Do not forcefully push the applicator into the vagina.
• Gently press the plunger until you hear a click sound.
• Remove the empty applicator from the vagina and discard it.

What does research suggest?

A study was conducted to evaluate the difference in effectiveness and hygiene of estrogen vaginal creams and vaginal tablets for the treatment of atrophic vaginitis (3).

For this study, 160 postmenopausal women with symptoms of atrophic vaginitis were selected and divided into two groups. One group of these women were given Vagifem (yuvafem) vaginal tablets and the other was treated with vaginal creams. They took the medication daily for the first 2 weeks and then twice daily for 12 weeks (3).

The symptoms of vaginal atrophy evaluated were dysuria (painful urination), dyspareunia (painful intercourse), vaginal itching, and dryness. However, the results of this study showed similar effectiveness of both formulations (3).

The patients were more satisfied with Vagifem (yuvafem) vaginal tablets as compared to vaginal creams due to hygiene. They reported that applying vaginal creams becomes unhygienic due to vaginal leakage which requires sanitary protection. Whereas, there is no such requirement with the vaginal tablets (3).

What are the potential side effects of Vagifem (yuvafem)?

Some potential side effects of Vagifem (yuvafem) include (1):

• Breast pain or tenderness
• Vomiting
• Headache
• Changes in sexual desire
• Hairloss
• Sudden feeling of heat or sweating
• Stomach pain
• Bloating
• Vaginal discharge
• Painful urination
• Back or joint pain
• Sleeping difficulties

However, taking exogenous estrogen may also increase the risk of developing ovarian cancer or gallbladder disease. Always monitor yourself for symptoms and excessive side effects must be discussed with your healthcare provider.

In my opinion

In my opinion as a pharmacist, there is no significant difference between either Vagifem or yuvafem. Both have the same dosage strength and are available in the same formulation of vaginal tablets.

Therefore, your doctor may prescribe you either Vagifem or yuvafem. Vagifem can only be a little costly due to the brand as compared to yuvafem which is generic. If you have financial constraints, then you must ask your doctor to prescribe you the cheaper form.

References