Why are you not losing weight on Ozempic®? 

Why are you not losing weight on Ozempic®? 

You may not be losing weight on Ozempic® because of the following reasons (1,2,3):

  • Inadequate dose
  • Improper dose administration 
  • Your genetics
  • Unhealthy diet
  • Lack of exercise 
  • An underlying health condition 
  • Concomitant use with some other medication

Inadequate dose

You may not lose weight on Ozempic® if your dose is too low. It is best to start from the lowest effective dose, especially when you are a new user, but the dose should be escalated once you are certain that the drug does not affect your body negatively. 

Every person has different symptoms and different physiological makeup. If your dose is not enough to make a noticeable change in your body, it will result in therapeutic failure. 

Improper dose administration 

Improper dose administration could be another possible reason why you’re not losing weight. Some people show non-adherence. They don’t take their meds on time or take them on alternate days deliberately. 

This improper way of taking Ozempic® or any other medication is the most common reason for not achieving your desired therapeutic goals. Make sure you remember to take your medication at the same time every single day until your doctor has advised you to. 

Your genetics 

It is a known fact that we all have different genetic makeups and this plays a huge role in how your body reacts to foreign chemicals. Medications are also foreign substances as they are not the normal part of your body. 

If your body doesn’t respond to Ozempic® well or you’re allergic to it, you will not see any therapeutic outcome. This is why it is advised to discontinue Ozempic if you have been using it for a week but don’t see any positive change. 

Unhealthy diet 

You may not be losing weight on Ozempic® because of your poor diet. It is not a magic pill and it can’t make the calories you consume magically disappear. You have to keep your diet balanced and healthy if you wish to see a positive change while being treated with Ozempic. 

Lack of exercise 

Lack of physical activity could be another reason why you can’t achieve your desired therapeutic goals. This is because your body is designed to be moved and physical activity literally helps your muscles breathe. Exercise helps strengthen your body and mind. 

Don’t just work out for the sake of losing weight as the benefits of staying active go way beyond that. Make it a part of your lifestyle and you’ll see a big change in your physical and mental health. 

An underlying health condition 

An underlying health condition may also make Ozempic® ineffective for you. Make sure your doctor rules out any such undiagnosed health condition that could be secretly affecting your body weight or any other physio function. 

Concomitant use with some other medication

The concomitant use of Ozempic® with any other medication that can affect its absorption in your body can make this medication ineffective. This is why it is important to not take any medication with Ozempic® that is incompatible. 

The best way to avoid this is to stick to your doctor’s recommended medications. You can also discuss the use of over-the-counter TC medications with your doctor to ensure your safety. 

Consult your healthcare provider

Talk to your doctor if you think Ozempic® is not working the way it should. Your doctor will determine the reason for drug insufficiency and will guide you accordingly. Some people may gain weight on Ozempic, which should be discussed with your doctor.

Make sure you are using this medication as directed by your doctor. Ozempic® may not work well for every individual. If it’s not the right choice of med for you, your doctor will switch you to another one since the long-term effects of Ozempic® are still being developed(4). 


  1. Scheen AJ. Semaglutide, once weekly GLP-1 receptor agonist (Ozempic®). Revue Medicale de Liege. 2019 Sep 1;74(9):488-94. https://pubmed.ncbi.nlm.nih.gov/31486321/ 
  2. Sivanand A, Gulliver WP, Josan CK, Alhusayen R, Fleming PJ. Weight loss and dietary interventions for hidradenitis suppurativa: a systematic review. Journal of Cutaneous Medicine and Surgery. 2020 Jan;24(1):64-72. https://pubmed.ncbi.nlm.nih.gov/31502868/ 
  3. Wilding JP, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MT, Wadden TA, Wharton S. Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine. 2021 Mar 18;384(11):989-1002. https://pubmed.ncbi.nlm.nih.gov/33567185/ 
  4. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007 May 1;132(6):2131-57.https://pubmed.ncbi.nlm.nih.gov/17498508/ 

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Institute for Quality and Efficiency in Health Care (IQWiG, Germany). Semaglutide (type 2 diabetes mellitus) – Benefit assessment according to §35a Social Code Book V. Dossier assessment; Commission A18-75. January 30, 2019. (IQWiG reports; Volume 721). Available from: https://www.ncbi.nlm.nih.gov/books/NBK538538/#i3331