Which one is better hydroxyzine or Zyrtec? (3+benefits)

In this article, we will compare Zyrtec and hydroxyzine. We will also discuss the mechanism of action, side effect profile, and the benefits of taking Zyrtec and hydroxyzine. Additionally, we will discuss some safety measures to take while consuming Zyrtec and hydroxyzine. 

Which one is better hydroxyzine or Zyrtec? 

The effect of the drug varies among individuals. Hydroxyzine may be beneficial for some individuals, while others may benefit from Zyrtec (cetirizine). Cetirizine is known to cross the blood-brain barrier to a small extent and hence produces less sedation compared to hydroxyzine. Research studies have shown Zyrtec to be more effective than hydroxyzine. (1,2,3)

Zyrtec and hydroxyzine both belong to the same class of drugs called antihistamines and have the same mechanisms of action. Both of the drugs act on the histamine H1 receptors and inhibit their action, which helps manage the symptoms of allergies such as inflammation, watery eyes, etc. 

If one of the drugs is not effective in treating your symptoms, you can choose to take another one. Zyrtec is available as an over-the-counter drug, whereas hydroxyzine is available only under prescription. 

What does the research suggest? 

A comparative study was conducted by Brenema et al. to analyse the safety and efficacy of cetirizine and hydroxyzine. The study included 188 patients who were diagnosed with chronic idiopathic urticaria. The study groups were administered 10mg of cetirizine once a day, 25mg of hydroxyzine 25 mg twice a day and a placebo for a period of 4 weeks. (2)

The study demonstrated that after one day of treatment with cetirizine (10mg/day), the symptoms of urticaria episodes diminished when compared to hydroxyzine and placebo. Finally, the study concluded that 10mg per day of cetirizine was as effective as 25mg of hydroxyzine given three times a day. (2)

In another study, Kalivas et al. also mentioned the same finding in their research, that 5 to 20 mg of cetirizine once a day was equivalently effective in treating allergic symptoms when compared to 25 to 75 mg of hydroxyzine given in divided doses. The common side effect associated with cetirizine use was somnolence. (3)

What is the difference between hydroxyzine and Zyrtec? 

Zyrtec and hydroxyzine belong to the same class of drugs called antihistamines. Zyrtec (cetirizine) is a highly selective histamine H1 receptor antagonist. Cetirizine inhibits H1 receptors, which are present in respiratory smooth muscle cells, vascular endothelial cells, immune cells and the GI tract. (1)

Zyrtec crosses the blood-brain barrier to a very small extent compared to hydroxyzine. Hence, it induces minimal sedation. It also reduces the inflammation associated with allergic rhinitis. The elimination half-life of cetirizine is 8.3 hours and is excreted through the kidneys. (1)

Hydroxyzine also acts by inhibiting the histamine H1 receptors. It also acts on the areas of the subcortical region in the brain, which explains the sedative effects of hydroxyzine. Hydroxyzine is rapidly absorbed from the GI tract, and its clinical effect is seen within 15 to 30 minutes after oral administration. (4)

Like all other drugs, hydroxyzine and Zyrtec are associated with side effects (1,4)

 Some of the side effects are rare. However, due to individual variability, you may or may not experience these side effects. If you notice any unwanted side effects after consuming either of the drugs, make sure you consult your physician for proper management. 

What are the measures to take while consuming hydroxyzine and Zyrtec? 

Zyrtec is available as an over-the-counter drug which can be used to treat the symptoms of allergies. Cetirizine is associated with sedation, and it is important to take the medication in moderation. If you overdose on Zyrtec, you will experience enhanced sedation, drowsiness and some cardiac abnormalities. Hence, it is important to use Zyrtec as prescribed by the doctor.

On the other hand, hydroxyzine is a prescription drug which is used to treat the same symptoms as cetirizine. Hydroxyzine is only available if a physician writes it for you. Overdose of hydroxyzine can cause increased heartbeat, delirium, seizures, hypotension, etc. 

If you are experiencing any severe side effects other than sedation, make sure you consult your physician for proper management. Avoid alcohol while taking antihistamines, as they can interact with the medication and increase the risk of side effects and sedation. Do not take both Zyrtec and hydroxyzine together or on the same day unless your physician prescribes it. Usually, only one antihistamine is sufficient to treat your allergic symptoms.

Avoid handling any heavy machinery, driving, or any other activities that involve concentration if you have consumed Zyrtec or hydroxyzine because the drugs have sedative effects, which can impact one’s level of activity.

In my experience

As per my knowledge and research studies, Zyrtec (cetirizine) has been shown to be more effective than hydroxyzine in managing allergic symptoms, with a lower dose and dosing schedule. However, the effect of the drug varies among individuals; some may benefit from Zyrtec, whereas others from hydroxyzine. 

If you think your symptoms are not subsiding, make sure you consult a physician for proper management. 

References