What antidepressants don’t cause excessive sweating?(2+)

In this article, we will discuss which antidepressants do not cause excessive sweating, the link between antidepressants and sweating, what factors can contribute to excessive sweating, and how to get rid of antidepressant-induced excessive sweating.

What antidepressants don’t cause excessive sweating?

Antidepressants that are less likely to cause excessive sweating include:

  • Agomelatine (Valdoxan)
  • Mirtazapine (Remeron)
  • Vortioxetine (Trintellix) (1)

 Agomelatine (Valdoxan):

Agomelatine is a newer antidepressant that belongs to the class of atypical antidepressants and works by antagonizing melatonin and serotonin receptors. It shows minimal excessive sweating, making it a potential option for patients worried about this side effect. (3)

Vortioxetine (Trintellix):

Vortioxetine is a relatively newer antidepressant that belongs to the class of serotonin modulators. It works by combining serotonin reuptake inhibition with serotonin receptor modulation.

Studies suggest that it may have a lower incidence of sweating compared to older SSRIs, making it an option for those suffering from this side effect. (4)

Mirtazapine (Remeron):

Mirtazapine acts on both the serotonin and norepinephrine systems. While it may cause weight gain, which can indirectly contribute to sweating, it is generally considered to be favorable regarding sweating compared to other antidepressants.

Mirtazapine’s antihistaminic effects may contribute to its lower incidence of sweating.

Communicating openly with your healthcare provider regarding all your concerns is advisable.

What is the link between antidepressants and excessive sweating?

Antidepressants are used to manage various mental health conditions and provide relief to those suffering from depression, anxiety, and obsessive-compulsive disorder. A common side effect associated with many antidepressants is excessive sweating.

Excessive sweating can not be pleasant for individuals struggling with mental health challenges. Excessive sweating, also known as hyperhidrosis, is reported by individuals suffering from mental health issues and taking certain antidepressants to get relief.

The exact mechanism behind this side effect is unclear. Still, it is believed to be related to the medications’ impact on the sympathetic nervous system or hypothalamus or an imbalance of alpha and beta-adrenergic receptor systems. (2)

What factors can contribute to excessive sweating caused by antidepressants?

These are some of the factors that can contribute to antidepressant-induced excessive sweating:

  • Individual Variability: People react differently to medications, and an individual’s unique physiology can influence how they respond to antidepressants. What causes excessive sweating in one person may not have the same effect in another.
  • Dosage and Medication Interactions: The dosage of antidepressant medications can play a role in excessive sweating. Additionally, interactions with other medications a person may be taking can influence how the body responds to antidepressants.
  • Treatment Duration: Excessive sweating may occur in the initial phase of antidepressant treatment and sometimes diminish over time as the body adjusts to the medication. However, some individuals may continue to experience sweating throughout their treatment.
  • Patient Predisposition: Certain individuals may be more predisposed to experiencing side effects such as excessive sweating based on factors like age, genetics, and pre-existing medical conditions.

It’s important for individuals to communicate any side effects they experience, including excessive sweating, to their healthcare providers. Always consult a healthcare professional for personalized advice and guidance on managing medication side effects.

How to get rid of antidepressant-induced excessive sweating?

Antidepressants that cause excessive sweating include most SSRIs like Lexapro, SNRIs, and tricyclic antidepressants. Excessive sweating may subside within a few weeks as your body adjusts to the medication.

If the symptom persists, talk to your healthcare provider. Your doctor may adjust your dose to reduce the symptoms, and if changing the dose does not help you, they may consider changing your antidepressant to one with a more favorable side effect profile.

What antidepressants are prescribed to individuals prone to excessive sweating?

Your healthcare provider can also consider prescribing drugs like terazosin, oxybutynin, and benztropine to help with excessive sweating as a side effect caused by the use of antidepressants or if you are suffering from hyperhidrosis. (6)

According to my knowledge, agomelatine, mirtazapine, and vortioxetine are among the antidepressants that cause minimal sweating and provide valuable options for patients suffering from mental health issues without unwanted side effects.

While individual responses to medications vary, discussing concerns with your healthcare provider can help make a treatment plan more suited to your needs.

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Sheffler ZM, Patel P, Abdijadid S. Antidepressants. [Updated 2023 May 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538182/


Marcy, Todd & Britton, Mark. (2005). Antidepressant-Induced Sweating. The Annals of Pharmacotherapy. 39. 748-52. 10.1345/aph.1E564.  https://www.researchgate.net/publication/8005985_Antidepressant-Induced_Sweating/citation/download


Sansone RA, Sansone LA. Agomelatine: a novel antidepressant. Innov Clin Neurosci. 2011 Nov;8(11):10-4. PMID: 22191083; PMCID: PMC3244295. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244295/


Trintellix, The Medication Guide approved by the U.S. Food and Drug Administration Revised: 1/2021 https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/204447s021s022lbl.pdf


Remeron, The Medication Guide by the U.S. Food and Drug Administration, https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020415s023s024.pdf


Kolli V, Ramaswamy S. Improvement of antidepressant-induced sweating with as-required benztropine. Innov Clin Neurosci. 2013 Nov;10(11-12):10-1. PMID: 24563813; PMCID: PMC3931183. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931183/

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