Should you take Buspirone once a day or multiple times per day? 

Should you take Buspirone once a day or multiple times per day? 

You should take Buspirone according to your doctor’s directions. Buspirone is usually taken 2 to 3 times a day (1). Taking it once a day will not likely help you achieve the therapeutic response for the entire day and the effects of the drug will wear off within a few hours. 

Even if you combine all three doses and take them at once, it will not only be insufficient for the entire day but can also cause side effects. This is why it’s best to take Buspirone as explained by your doctor or pharmacist.

Dosage recommendations for Buspirone

For oral dosage forms (tablets), the typical starting dose for adults is usually 7.5 mg taken two times a day (1). Your doctor may increase your dose as needed, but it usually does not exceed 60 mg a day (1). 

For children, the use and dose must be determined by a doctor. It’s important to follow your healthcare provider’s instructions carefully and never adjust the dosage on your own. 

Always take Buspirone as prescribed to ensure its safe and effective use for managing anxiety. If you have any concerns or questions about the dosage, don’t hesitate to consult your healthcare provider for guidance.

How to ensure the safe and effective use of Buspirone?

Some basic points to ensure the safe and effective use of Buspirone include (1,2):

  • Always take Buspirone exactly as your doctor instructed. Follow the dosage and timing recommendations carefully, and never adjust the dose on your own.
  • Buspirone may take some time to show its full effect. Give it a few weeks to see how it works for you. Don’t expect immediate results.
  • Alcohol and some medications can interact with Buspirone, leading to unwanted effects. Inform your doctor about all the medications and supplements you are taking to avoid potential interactions.
  • Keep in touch with your healthcare provider and share any concerns or side effects you experience. Your doctor will monitor your progress and adjust the dosage if necessary.
  • If you wish to discontinue Buspirone, consult your doctor first. Suddenly stopping the medication may lead to withdrawal symptoms. Your doctor will help you gradually reduce the dosage if needed.
  • Buspirone can cause dizziness or drowsiness. Be cautious while driving or operating heavy machinery until you know how it affects you.
  • Let your doctor know about any medical conditions you have, such as liver or kidney problems, as they may affect the use of Buspirone.
  • Avoid grapefruit, as grapefruit and grapefruit juice can interfere with Buspirone’s effectiveness. It’s best to avoid them while taking this medication.
  • Keep Buspirone in a cool, dry place, away from children and pets. Follow any storage instructions provided on the medication packaging.

Final words

In conclusion, the decision on whether to take Buspirone once a day or multiple times per day depends on various factors, including the individual’s medical condition, the doctor’s recommendation, and the specific formulation of the medication.

It is essential for patients to follow their healthcare provider’s instructions and communicate any concerns or changes in their response to the medication.

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The Food and Drug Administration (FDA). Highlights of prescribing information and Patient Instruction Sheet. BuSpar® (buspirone HCl, USP). Available from:


LABEL: BUSPAR- buspirone hydrochloride tablet. DailyMed [Internet]. Available from: