Is Z-Pak for kidney infection? (3+ indications)

In this article, we will discuss the use of Z-Pak and its effect on kidney infection. We will also discuss the side effects of Z-Pak indicated for infection, along with some research studies. Additionally, we will also discuss how to use Z-Pak safely and effectively. 

Is Z-Pak for kidney infection?

Z-Pak can be used to treat kidney infections. Typically, Z-Pak is used to treat a wide range of bacterial infections in the body, and it can help treat infection in the kidneys. The active ingredient present in Z-Pak is azithromycin, which is a macrolide antibiotic. The dose of azithromycin can be given as 250mg, 500mg, 30mg/kg for otitis media and 1g for adults to treat infection caused by Chlamydia. (1) 

Z-Pak can be used to treat any bacterial infection in the body, but it is not recommended in patients with impaired renal function. It is absolutely crucial to consult a physician in order to receive the proper assessment and treatment required to treat the infection and to avoid any potential adverse effects.

What does the research suggest? 

Z-Pak contains Azithromycin, which is a broad-spectrum antibiotic. It is used in the treatment of various bacterial infections caused by chlamydiae, legionella, mycoplasma and mycobacteria. Azithromycin is effective in treating community-acquired pneumonia, acute otitis media, and chronic obstructive pulmonary disease, and it is used as a prophylactic drug to prevent infection in some cases. (1) 

Azithromycin is excreted through the hepatio-biliary system, and a small amount of the drug is excreted through the urine; hence, Azithromycin is not suitable for infections associated with the kidney and bacteriuria. (2)

A clinical study by David H et al. found that a single dose of 1g of Azithromycin was effective in treating uncomplicated genital chlamydial infections in both men and women, in which the success rate was 97% and 95%, respectively. Among these, 17% of the patients who received Azithromycin experienced mild-to-moderate side effects. (3)

How does Z-Pak treat kidney infection? 

Azithromycin is a broad-spectrum antimicrobial which is used to treat a wide variety of bacterial infections. Azithromycin binds to the 23S portion of the 50S ribosomal subunit of bacteria, and it inhibits the protein synthesis in the bacteria by hindering the action of aminoacyl-tRNA. Protein synthesis is essential for bacteria to survive. When protein synthesis is inhibited, it leads to the destruction of bacterial cells. (1)

Azithromycin has a greater affinity to the ribosome of gram-positive bacteria compared to gram-negative bacteria. Azithromycin is a bacteriostatic agent that prevents the growth of bacteria rather than killing it. However, at higher doses, Azithromycin has been shown to be bactericidal. (1)

What are the potential side effects of Z-Pak for kidney infection?

Z-Pak should be used in moderation to avoid severe side effects. Z-Pak is associated with a few side effects, such as: 

• Diarrhoea/loose stools
• Nausea
• Abdominal pain
• Palpitations
• Chest pain
• Dyspepsia
• Flatulence
• Vomiting
• Fatigue
• Dizziness
• Headache
• Vertigo 
• Rash 
• Pruritus
• Angioedema
• Interstitial nephritis 
• Acute renal failure
• Hearing disturbances 

It should be noted that some of the side effects are uncommon, and the side effects of Azithromycin differ from person to person. It is important to seek medical help if you are experiencing any unwanted side effects after consuming Azithromycin. 

What should you know while taking Z-Pak?

Z-Pak is an antibiotic containing Azithromycin as its active ingredient. The dose of Azithromycin can range from 250mg to 1g given as a single for 3 to 5 days to treat infection, and in children, the dose is calculated according to their weight. The duration of treatment and dosing depends on the individual needs and conditions. 

It is not recommended to take Azithromycin without a physician’s approval. Taking Azithromycin in an incorrect dose or for a longer duration may cause the bacteria in your body to develop resistance to the drug. Once the bacteria develop resistance, the drug becomes ineffective. 

Overdosing of Azithromycin can lead to abnormal cardiac functioning, and the symptoms can range from irregular heartbeat to a myocardial infarction. A Case Study Report life-threatening bradyarrhythmia in a 9-month-old infant who was administered a 50mg/kg dose of Azithromycin. (4)

It is very important to take Azithromycin under the guidance of a qualified healthcare physician to avoid any unwanted side effects. 

How to use Z-Pak safely and effectively? 

There are a few steps you have to follow in order to use Z-Pak safely and effectively, such as: 

• Always take the drug as prescribed by your physician. 
• Avoid taking a double dose if you forget to take your medication. Set up an alarm which will help remind you to take your medication on time.
• Do not skip or stop taking the drug. Always complete the treatment course as prescribed by your physician. If you stop taking Z-Pak mid-course, it will not treat the infection effectively. 
• If you are experiencing nausea or vomiting after consuming Z-Pak, you can try taking it with food, which will help manage the feeling of nausea. 
• Always take the medication at the same time as prescribed by your physician. 
• Do not break, chew or crush the tablet/capsule before consuming. 
• Z-Pak may interact with a few of the OTC medications, vitamins and herbal medications; make sure you consult your physician if you want to take any OTC medication. 
• Avoid drinking alcohol and grapefruit juice as it can interact with Z-Pak and reduce its efficacy. 
• Be aware of the side effects caused by Z-Pak, and consult your physician if you experience any. Do not stop taking the medication because you are experiencing side effects. 
• Azithromycin may reduce the effectiveness of birth control pills; if you are taking birth control pills, make sure you inform your healthcare professional. 
• Always attend regular check-ups to monitor your progress and make the necessary changes. 
• Always check the expiry date of the drug before consuming and avoid taking the drug if it has expired. 

In my experience

As per my knowledge, Z-Pak can be used to treat kidney infections. However, it is not very effective in treating UTIs when compared to other medications such as sulfamethoxazole, trimethoprim, amoxicillin, etc. However, the decision will be made by your physician; hence, it is essential to consult a physician for proper treatment. 

References