How long does Diclofenac Sodium stay in your system? 

How long does Diclofenac Sodium stay in your system? 

Diclofenac sodium stays in your system for about 15-18 hours. This time may vary, as it can depend on several factors. In healthy individuals who are free from anything that can make Diclofenac linger around for longer, the drug is almost gone within 18 hours. 

Half-life of Diclofenac 

The elimination half-life of Diclofenac is about 1.5-2.5 hours, which is the time after which the initial concentration of Diclofenac reduces to half(1)

The remaining concentration continues to reduce to half every 1.5-2.5 hours until the entire drug is eliminated from your body. This can take up to 15-18 hours if you don’t take an additional Diclofenac dose. However, this time period may vary from person to person.

Factors Affecting How Long Diclofenac Sodium Stays in Your System

There are a number of factors that can affect the stay time of Diclofenac in your body, like your:

  • Age
  • Weight
  • Dosage strength
  • Frequency of dose administration
  • Underlying medical conditions
  • Concomitant use of other medications, which can interfere with the absorption and elimination of Diclofenac. 

People who have liver or kidney diseases usually take longer to metabolise and eliminate the drug. This is because the liver and kidneys are primarily involved with drug metabolism and if they’re not working as well as they should, your body fails to remove the drug effectively. 

This is why such people usually take adjusted doses. Diclofenac is generally a well-tolerated medication, but it can cause side effects in some people. If you start to feel unusual while taking Diclofenac, talk to your healthcare provider. 

Final words

In conclusion, Diclofenac leaves your body within 18 hours. If you are concerned that the drug may stay longer in your body or you still experience side effects, you should consult your healthcare provider. 

Although Diclofenac is available over the counter, you still need to make sure whether or not it’s safe for you to take this medication. If you’re not sure about the right dose, you should ask your pharmacist. 

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Small RE. Diclofenac sodium. Clin Pharm. 1989 Aug;8(8):545-58. PMID: 2670397. Available from: