How do you get rid of Trazodone-induced headaches?(3+ remedies)

In this article, we will discuss how to get rid of Trazodone-induced headaches along with its potential causes and management in the light of research studies.

How do you get rid of Trazodone-induced headaches?

You can get rid of Trazodone-induced headaches in the following ways:

  • Use over-the-counter (OTC) painkillers
  • Dose adjustment
  • Stay hydrated
  • Avoid other potential triggers
  • Lifestyle modifications

Use over-the-counter (OTC) painkillers

OTC painkillers, such as Ibuprofen and Acetaminophen are safe and can be taken for temporary relief from Trazodone-induced headaches. Adults should not take more than 3000mg of Acetaminophen in a single day.

NSAIDs like Ibuprofen when taken for a short time (no longer than 10 days) can be safe for most people. However, you should consult the healthcare provider before it’s prolonged use. (1)

Dosage adjustment

If the headaches persist for more than 7 days or are unbearable, the healthcare provider should be asked to adjust the dosage of Trazodone. Also, Trazodone should not be discontinued abruptly. (3) It should be tapered gradually if you are using the medicine for a longer period. Abrupt discontinuation may result in undesirable Trazodone withdrawal syndrome.

Stay hydrated

Water deprivation can cause the onset of headaches. Stay well hydrated and ensure to take an adequate amount of fluids throughout the day. It will reduce the severity and frequency of headaches.

Avoid other potential triggers

Some common headache triggers include exposure to bright lights, loud noises and strong odours. Minimize your exposure to these triggers if they seem to worsen your headaches.

Lifestyle modifications

Engage yourself in stress management activities like deep breathing exercises, yoga, walking etc. Gentle massage on your head and neck muscles can relieve the headaches. Headaches won’t go away permanently like this but you may feel better.

Reduce/avoid alcohol and caffeine, as they can trigger headaches. In some cases, caffeine withdrawal can trigger headaches but excessive caffeine intake can also contribute to headaches. Taking an adequate amount of sleep can also help to cope with the severity of headaches.

Causes of Trazodone-induced headaches

Trazodone may cause headaches because of the following causes:

  • Sensitivity to Trazodone is the main factor due to which people become more prone to experience headaches. Trazodone-sensitive individuals may experience headaches even at low doses (3).
  • Serotonin is a neurotransmitter that regulates pain perceptions. Trazodone alters Serotonin levels in the brain which can trigger headaches (4).
  • Trazodone can cause changes in blood pressure which may affect the blood flow to the brain. This altered blood flow could contribute to the headaches (1).


If the Trazodone-induced headaches do not go away, please consult your healthcare provider. These side effects are expected to go away after discontinuation of Trazodone, however, it should be gradually discontinued.

Trazodone-induced headaches can be an undesirable side effect of this medicine. However, with proper management and lifestyle changes, such as staying well hydrated, being involved in stress management activities, and taking over-the-counter painkillers, you can reduce the effect of these headaches on your daily activities.

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Prior MJ, Codispoti JR, Fu M. A randomized, placebo-controlled trial of acetaminophen for the treatment of migraine headache. Headache. 2010 May;50(5):819-33. doi: 10.1111/j.1526-4610.2010.01638.x. Epub 2010 Mar 5. PMID: 20236342.


Huang-Chen Chen MD, Shih-Jen Tsai MD; First published: 19 December 2011.



Alessandro Cuomo Angelo Bianchetti Annachiara Cagnin Domenico De Berardis Ignazio Di Fazio Raffaele Antonelli Incalzi Camillo Marra Francesca Neviani Pier Francesco Laurenzi Ferdinando Nicoletti. Vol. 69: ISSUE 2 – JUNE 2021.

DOI: 10.36150/2499-6564-N320. Published: 2021-03-31.



Justin J. Shin; Abdolreza Saadabadi.Last Update: July 10, 2022. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.


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