Does Wellbutrin cause vasoconstriction? (+5 tips)

In this brief article, we will answer the question ” Does Wellbutrin cause vasoconstriction? “. We will also explain why Wellbutrin causes vasoconstriction and what to do in this case.

Does Wellbutrin cause vasoconstriction?

Yes, Wellbutrin can cause vasoconstriction. Wellbutrin has been reported to cause vasoconstriction, which is the narrowing of blood vessels. Vasoconstriction can lead to increased blood pressure and reduced blood flow to certain parts of the body. Wellbutrin works on neurotransmitters that can influence blood vessel constriction.(1)

Individual responses to Wellbutrin can vary and not everyone will experience vasoconstriction or related effects on blood pressure. However, individuals with pre-existing cardiovascular conditions or high blood pressure need to be closely monitored while taking Wellbutrin.

Why does Wellbutrin cause vasoconstriction?

Wellbutrin affects the levels of neurotransmitters in the brain, including norepinephrine and dopamine. Norepinephrine can lead to various physiological changes such as vasoconstriction. When norepinephrine is released, it causes blood vessels to constrict, leading to an increase in blood pressure. The vasoconstrictive effect is a common physiological response to stress or medications that influence the release and reuptake of neurotransmitters. 

Wellbutrin’s impact on norepinephrine levels can result in vasoconstriction, especially at higher doses. This vasoconstrictive effect can contribute to increased blood pressure and may pose risks for individuals with pre-existing cardiovascular conditions. (2)

What does the research suggest?

There is limited research on vasoconstriction caused by Wellbutrin. However, some cases were reported. Clinical studies were made on 93,097 individuals who experienced side effects of Wellbutrin and showed that vasoconstriction was observed. Vasoconstriction was found mostly in female patients with age range 30-39. (3)

Another study showed that Wellbutrin can cause an exacerbation of hypertension in some patients. However, this study suggests that the cardiovascular profile of Wellbutrin can be safe and useful for depressed patients with a history of cardiovascular disease.(1)


What to do if Wellbutrin causes vasoconstriction?

If you are experiencing vasoconstriction or elevated blood pressure as a side effect of Wellbutrin, it’s crucial to consult your healthcare providers. They can assess your specific situation and determine the most appropriate course of action. Here are some potential approaches that healthcare providers might consider:

  • Dosage adjustment: In some cases, lowering the dosage of Wellbutrin can help alleviate vasoconstriction-related symptoms and reduce the medication’s impact on blood pressure.
  • Alternative medication: In case vasoconstriction persists, your healthcare provider might consider giving you an alternative antidepressant with a different mechanism of action.
  • Monitoring and lifestyle changes: It’s essential to monitor your blood pressure regularly. Your healthcare provider may recommend lifestyle changes such as changes in diet, smoking cessation in case you smoke, exercise, stress reduction techniques and limitation of caffeine intake. These changes can positively influence blood pressure.
  • Supplemental medications: Your healthcare provider may prescribe additional medication to help manage the vasoconstriction symptoms caused by Wellbutrin.
  • Regular follow-ups: Regular appointments with your healthcare providers are essential as they can monitor your progress, adjust treatment and address any side effects you might experience.(4)

What factors contribute to vasoconstriction induced by Wellbutrin? 

Vasoconstriction induced by Wellbutrin can be influenced by various factors related to the medication’s pharmacological properties and the individual’s psychological response. Some of the factors that contribute to vasoconstriction induced by Wellbutrin include:

Alteration of norepinephrine and dopamine levels: Wellbutrin increases the levels of norepinephrine and dopamine in the body. These neurotransmitters play an important role in regulating blood vessel constriction.

Stimulating effects: Wellbutrin has a stimulating effect on the central nervous system. This stimulation triggers the release of substances that cause vasoconstriction.

Dosage: Higher doses of Wellbutrin are more likely to cause vasoconstriction. 

Interaction with other medications: Wellbutrin can interact with other medications and amplify its vasoconstrictive effects.

Pre-existing conditions: Individuals with pre-existing cardiovascular conditions such as hypertension or heart attack are at a greater risk of experiencing vasoconstriction induced by Wellbutrin.

Individual variation: Each person’s body responds differently to medications. Some individuals are more prone to experiencing vasoconstriction due to their unique physiological and genetic makeup. (5)



In conclusion, Wellbutrin can cause vasoconstriction. You must maintain regular monitoring of your blood pressure and report all the side effects promptly to your healthcare provider to assess your situation and take the most appropriate course of action.

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Roose SP, Dalack GW, Glassman AH, Woodring S, Walsh BT, Giardina EG. Cardiovascular effects of bupropion in depressed patients with heart disease. Am J Psychiatry. 1991 Apr;148(4):512-6.


Smith MD, Maani CV. Norepinephrine. [Updated 2023 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-


Fava M, Rush AJ, Thase ME, Clayton A, Stahl SM, Pradko JF, Johnston JA. 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL. Prim Care Companion J Clin Psychiatry. 2005;7(3):106-13.


Calvi A, Fischetti I, Verzicco I, Belvederi Murri M, Zanetidou S, Volpi R, Coghi P, Tedeschi S, Amore M, Cabassi A. Antidepressant Drugs Effects on Blood Pressure. Front Cardiovasc Med. 2021 Aug 3;8:704281.


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