Does trazodone prevent migraines? (+5 management tips)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss whether trazodone helps in the prevention of migraines. We will also delve into the dosage of trazodone for the management of migraines, along with research studies linking the use of trazodone in the prevention of migraines. Additionally, we will explore alternative management tips for migraines if trazodone fails to prevent them.
Does trazodone prevent migraines?
Yes, trazodone may prevent migraines. However, while some research studies have provided evidence for trazodone’s role in reducing migraines, it is not the first-line medication of choice for preventing and managing migraines.
It is an antidepressant medication commonly used in the management of various mental health disorders such as depression, anxiety, and post-traumatic stress disorders. Additionally, it is also employed in the treatment of fibromyalgia and chronic pain (5).
While the use of trazodone in the clinical setting for the prevention of migraines is less common, research findings have demonstrated its effectiveness in preventing the onset of migraines.
It is important to note that this medication is also associated with certain side effects which may exacerbate the symptoms of migraines in some individuals. These side effects may include nausea, vomiting, headaches, and dizziness.
What does research suggest?
According to research, trazodone has the potential to be used in the prevention of migraines. In a study, trazodone was administered at a daily dose of 70mg for a period of 6 months to individuals with migraines, aiming to prevent migraine episodes. The results demonstrated the effectiveness of trazodone in reducing the frequency and intensity of migraine episodes in these individuals compared to a placebo (2).
However, in another study, trazodone was investigated for its potential in preventing migraine episodes in children over a duration of 1 month. Unfortunately, no significant improvement in reducing the frequency or preventing episodes of migraines was observed in these individuals (3).
What is the dosage of trazodone for migraine prevention?
According to research findings, this medication can be used at a dosage of 1 mg per kg of a patient for the prevention of migraines. The duration of treatment may vary from a few weeks to months, depending on the severity and frequency of migraine attacks (2).
While some research studies have demonstrated the effectiveness of trazodone in preventing migraines, others have shown conflicting results. It is important to consult your healthcare provider before taking any medication to prevent unwanted side effects that may worsen your symptoms.
What to do if trazodone fails to prevent migraines?
If trazodone proves ineffective in preventing the frequency or intensity of migraine attacks, it is advisable to consult your healthcare provider. They will assess your symptoms and may suggest alternative medications that are more effective in the management and prevention of migraines compared to trazodone.
However, it’s crucial not to make abrupt decisions to stop this medication, as the sudden discontinuation of trazodone may lead to withdrawal effects that could worsen your symptoms.
Moreover, your healthcare provider will take into account various factors such as your medical history, overall health, and interactions of trazodone with other medications to ensure the effectiveness of the treatment.
They may also consider lifestyle modifications and behavioral interventions that can complement the pharmacological approach for preventing migraines and alleviating associated symptoms.
What are the management tips for migraines?
The management and prevention of migraines often involve a combination of both pharmacological and non-pharmacological approaches.
Pharmacological treatments aim to address symptoms associated with migraines, such as nausea, vomiting, and headaches (3).
- Over-the-counter analgesics like aspirin and acetaminophen can effectively manage head pain and discomfort during migraines.
- Medications such as Triptans and ergotamines can aid in preventing migraine attacks by reducing pain sensations.
- Metoclopramide is another option for managing nausea and vomiting related to migraines.
In addition to pharmacological treatments, non-pharmacological approaches play a crucial role in preventing migraines. These approaches may include (4):
- Lifestyle modifications and behavioral changes
- Consistent sleep routine with regular sleep and wake times
- Avoiding foods containing tyramine, caffeine, or artificial sweeteners.
- Adequate water intake
- Regular exercise, such as swimming or yoga, to reduce stress and tension
- Routine practices like meditation and head massages
In my opinion, these non-pharmacological approaches, when combined with medications, contribute to the overall management and prevention of migraines. It’s important to consult with a healthcare professional to develop an individualized plan that considers both pharmacological and non-pharmacological strategies for optimal effectiveness.
Was this helpful?
References
1.-
Battistella PA, Ruffilli R, Cernetti R, Pettenazzo A, Baldin L, Bertoli S, Zacchello F. A placebo-controlled crossover trial using trazodone in pediatric migraine. Headache. 1993 Jan;33(1):36-9. doi: 10.1111/j.1526-4610.1993.hed3301036.x. PMID: 8436497. https://pubmed.ncbi.nlm.nih.gov/8436497/
2.-
Victor S, Ryan SW. Drugs for preventing migraine headaches in children. Cochrane Database Syst Rev. 2003;(4):CD002761. doi: 10.1002/14651858.CD002761. Update in: Cochrane Database Syst Rev. 2014;7:CD002761. PMID: 14583952. https://pubmed.ncbi.nlm.nih.gov/14583952/
3.-
Ferrari MD, Goadsby PJ, Burstein R, Kurth T, Ayata C, Charles A, Ashina M, van den Maagdenberg AMJM, Dodick DW. Migraine. Nat Rev Dis Primers. 2022 Jan 13;8(1):2. doi: 10.1038/s41572-021-00328-4. PMID: 35027572.
4.-
Haghdoost F, Togha M. Migraine management: Non-pharmacological points for patients and health care professionals. Open Med (Wars). 2022 Nov 23;17(1):1869-1882. doi: 10.1515/med-2022-0598. PMID: 36475060; PMCID: PMC9691984. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691984/
5.-
Shin JJ, Saadabadi A. Trazodone. [Updated 2022 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470560/
Find a supportive therapist who can help with Depression.
Discover the convenience of BetterHelp, an online therapy platform connecting you with licensed and accredited therapists specialized in addressing issues such as depression, anxiety, relationships, and more. Complete the assessment and find your ideal therapist within just 48 hours.
AskYourPharm is user-supported. We may earn a commission if you sign up for BetterHelp’s services after clicking through from this site
