Does trazodone help with alcohol withdrawal? (+15 symptoms)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will explore the role of trazodone in managing symptoms associated with alcohol withdrawal. We will also discuss the research findings that demonstrate the effectiveness of trazodone in addressing alcohol withdrawal symptoms. Additionally, we will discuss other management tips and medications that can be utilized for the treatment of alcohol withdrawal.
Does trazodone help with alcohol withdrawal?
Yes, trazodone does help with alcohol withdrawal. It is effective in managing various symptoms associated with alcohol withdrawal, including anxiety, depression, restlessness, and alcohol cravings.
However, it is imperative to use trazodone under the supervision of healthcare professionals. Moreover, maintaining a supportive and understanding environment is crucial during the alcohol withdrawal period.
Generally, trazodone is an antidepressant medication, that is commonly employed in managing diverse health conditions such as depression, post-traumatic stress disorder, and chronic pain (1).
What is the dosage of trazodone for managing alcohol withdrawal?
Research findings suggest that utilizing trazodone at a daily dosage of 50 mg can be effective in managing diverse symptoms of alcohol withdrawal (2). However, the dosage can be increased up to 600 mg daily to achieve therapeutic benefits in some individuals (3).
A study demonstrated the efficacy of trazodone at this lower dosage for addressing these symptoms in individuals over a 16-week period. The results indicate that trazodone can be successfully employed in the management of symptoms associated with alcohol withdrawal at this dosage (2).
What does research suggest?
Research findings indicate that trazodone can effectively alleviate symptoms such as insomnia, alcohol cravings, anxiety, and irritability associated with alcohol withdrawal.
In a comprehensive research study, a daily dosage of 600 mg of trazodone was administered to a patient with chronic alcohol addiction. The symptoms, following alcohol cessation, notably improved after a few weeks of trazodone treatment, showcasing the medication’s effectiveness in managing alcohol withdrawal symptoms (3).
In a separate study, the use of trazodone at a daily dosage of 150 mg proved beneficial in addressing sleep disturbances experienced by individuals following alcohol discontinuation. This not only reduced sleep latency and insomnia but also alleviated anxiety and low mood in these patients (5).
What are the symtoms of alcohol withdrawal?
Alcohol withdrawal may occur due to the sudden discontinuation of alcohol after prolonged consumption. Symptoms associated with alcohol withdrawal may include:
- agitation
- aggression
- anxiety
- restlessness
- nausea
- irritability
- depression
- hallucinations
- sedation
- confusion
- dizziness
- headache
- lightheadedness
- insomnia
- palpitations
It’s important to note that the intensity and frequency of these symptoms may vary from one individual to another, depending on their physical and mental health status. Chronic alcohol users are prone to experience severe withdrawal symptoms after stopping alcohol.
How to prevent alcohol withdrawal?
Preventing alcohol withdrawal is a complex process, particularly for individuals with chronic alcohol use. Instead of an abrupt cessation, a gradual reduction in alcohol intake emerges as a key strategy to mitigate the risks associated with withdrawal syndrome, encompassing a variety of symptoms.
For those considering alcohol withdrawal, consulting with healthcare professionals is crucial. They can evaluate the individual’s condition and devise a personalized tapering plan to meet their specific requirements. In certain instances, medical practitioners may prescribe medications to assist in managing withdrawal symptoms including trazodone.
A fundamental aspect of alcohol withdrawal prevention involves adopting a healthy lifestyle including maintaining a balanced diet, staying adequately hydrated, and engaging in regular exercise. These practices have demonstrated effectiveness in improving mood and reducing stress, which are factors that may intensify during and after alcohol withdrawal.
Additionally, sustaining a healthy lifestyle significantly contributes to overall mental and emotional well-being, creating a supportive environment for individuals facing the challenges of alcohol withdrawal.
What other medications can help with alcohol withdrawal?
While trazodone is effective in alleviating various symptoms of alcohol withdrawal, it is not the first-line medication commonly employed for managing these symptoms. Other medications, such as benzodiazepines, are more commonly utilized for addressing severe alcohol withdrawal symptoms.
Additionally, naltrexone aids in reducing cravings to prevent relapse, whereas disulfiram discourages drinking by inducing an aversive reaction to alcohol consumption.
Other medications that can be employed in the management of alcohol withdrawal may include the following (4):
- olanzapine
- diazepam
- haloperidol
- acamprosate
- valproic acid
- clonidine
- chlordiazepoxide
In my opinion, these medications are designed to alleviate specific symptoms related to alcohol withdrawal. However, the decision on which medication to use should be based on the individual’s symptoms, overall health status, and medical history of a patient.
Was this helpful?
References
1.-
Shin JJ, Saadabadi A. Trazodone. [Updated 2022 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470560/
2.-
Janiri L, Hadjichristos A, Buonanno A, Rago R, Mannelli P, de Risio S. Adjuvant trazodone in the treatment of alcoholism: an open study. Alcohol Alcohol. 1998 Jul-Aug;33(4):362-5. doi: 10.1093/oxfordjournals.alcalc.a008405. PMID: 9719394. https://pubmed.ncbi.nlm.nih.gov/9719394/
3.-
Borras L, de Timary P, Constant EL, Huguelet P, Eytan A. Successful treatment of alcohol withdrawal with trazodone. Pharmacopsychiatry. 2006 Nov;39(6):232. doi: 10.1055/s-2006-951385. PMID: 17124647. https://pubmed.ncbi.nlm.nih.gov/17124647/
4.-
Tiglao SM, Meisenheimer ES, Oh RC. Alcohol Withdrawal Syndrome: Outpatient Management. Am Fam Physician. 2021 Sep 1;104(3):253-262. PMID: 34523874. https://pubmed.ncbi.nlm.nih.gov/34523874/
5.-
Friedmann PD, Rose JS, Swift R, Stout RL, Millman RP, Stein MD. Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial. Alcohol Clin Exp Res. 2008 Sep;32(9):1652-60. doi: 10.1111/j.1530-0277.2008.00742.x. Epub 2008 Jul 8. PMID: 18616688; PMCID: PMC2567128. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567128/
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