Does trazodone contain iron? (+5 differences)

 In this article, we will delve into the composition of trazodone formulations, specifically exploring whether iron is a component. Additionally, our discussion will extend to the various formulations of trazodone available in the market and their ingredients.

Does trazodone contain iron?

No, trazodone does not contain iron. The available formulations of trazodone do not typically include iron as an active or inactive ingredient.

Trazodone is an antidepressant medication that modulates serotonin levels in the brain, aiding in the alleviation of symptoms associated with various mental disorders. It is primarily prescribed for the treatment of depression, anxiety, chronic pain in fibromyalgia, and obsessive-compulsive disorder (1).

On the other hand, iron is a key component of hemoglobin. In cases of iron deficiency, healthcare professionals may recommend iron supplements to help restore iron levels (2). However, iron supplements should be taken under the guidance of a healthcare professional.

What is the composition of trazodone formulation?

Trazodone is present in various commercially available formulations with different strengths which incorporate distinct excipients or inactive ingredients. The composition of trazodone formulations may contain the following (4,5):

Active ingredient Trazodone hydrochloride
Inactive ingredients binders, fillers, disintegrants, diluents, lubricants, preservatives 
Dosage form tablets
Strengths  50 mg, 100 mg or 150 mg

 These inactive ingredients or excipients play a role in stabilizing the final dosage form of the medication, but they do not have any pharmacological effects.

What is the composition of iron supplements?

The composition of iron supplements typically comprises forms of iron that are readily available and easily absorbed by the body. These supplements often incorporate various iron salts, including ferrous sulfate or ferrous gluconate, as active ingredients.

Iron supplements are commonly derived from natural resources, with the iron present sourced from minerals or ores. Additionally, iron is naturally found in various dietary sources such as kale, spinach, beetroot, and carrots (2).

What are the differences between trazodone and iron supplements? 

Iron and trazodone are quite distinct in their nature, purposes, and usage. Here are key differences between iron and trazodone (1,3):

Features Trazodone Iron
Nature synthetic medication chemical element (natural and synthetic sources)
Usage depression, anxiety, fibromyalgia, pain iron deficiency and anemia
Pharmacological effects regulate mood and behavior, alleviate pain synthesis of hemoglobin,  erythropoiesis,  oxygen storage 
Side effects nausea, dizziness, dry mouth, headaches,  gastrointestinal discomfort, constipation, and nausea
Availability only as a prescription medication dietary supplements and in various formulations for medical use

Does trazodone interact with iron?

Iron is not typically considered to interact with trazodone or other antidepressant medications. However, individual responses to medications can vary based on underlying health conditions and other factors.

If there are concerns about potential interactions or if someone is contemplating taking iron supplements while using trazodone, it is essential to consult with a healthcare provider.

Healthcare providers may offer personalized advice, taking into account an individual’s specific health situation. They can assess potential interactions or side effects based on the medications in use and the person’s underlying health conditions.

Can you add iron to the trazodone formulation?

Combining iron with trazodone generally does not pose any problems. However, it is advisable to avoid this combination because iron plays no role in the manufacturing of trazodone formulations or in enhancing the efficacy of trazodone in the management of various mental disorders for which trazodone is typically prescribed.

Iron and trazodone serve different therapeutic purposes and have distinct indications. Iron is found in medications used to treat iron deficiency and anemia. Adequate iron levels are essential to support the continuous renewal of red blood cells in the bone marrow (3).

Iron supplements are available in various forms; however, they are typically not included in prescription medications like trazodone or other antidepressants.

 In my opinion, trazodone formulations do not include iron. The commercial formulations of trazodone incorporate trazodone hydrochloride as their active ingredient. Alongside this active component, these formulations also consist of various inactive ingredients that contribute to the creation of a stable dosage form of trazodone. However, no product of trazodone contains iron.

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Shin JJ, Saadabadi A. Trazodone. [Updated 2022 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


Lal A. Iron in Health and Disease: An Update. Indian J Pediatr. 2020 Jan;87(1):58-65. doi: 10.1007/s12098-019-03054-8. Epub 2019 Sep 13. PMID: 31520313.


Nguyen M, Tadi P. Iron Supplementation. 2023 Jul 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32491308.


Brogden RN, Heel RC, Speight TM, Avery GS. Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs. 1981 Jun;21(6):401-29. doi: 10.2165/00003495-198121060-00001. PMID: 7018873.

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