Does trazodone contain aspirin? (3+ differences)

In this article, we will discuss whether trazodone contains aspirin. We will also discuss the differences between trazodone and aspirin and other related information.

Does trazodone contain aspirin?

No, trazodone does not contain aspirin. Trazodone and aspirin are two different drugs. Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) and an antidepressant. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID). 

Trazodone is an FDA-approved medication for major depressive disorder (MDD). Aspirin is also known as acetylsalicylic acid (ASA) and salicylic acid is the primary metabolite of aspirin. 

Trazodone and aspirin are entirely different drugs. They differ in their mechanism of action, indications, side effects, and contraindications. 

How does trazodone differ from aspirin?

Trazodone and aspirin are different in the following aspects:

Mechanism of action: 

Trazodone is a SARI and it works by blocking the reuptake of serotonin which increases serotonin levels in the body. It also acts as an antagonist of some serotonin receptors and histamine (H1) and alpha-1 adrenergic receptors (1).

Due to the effects on serotonin, trazodone has antidepressant activity. As it blocks different receptors, it also has a sedative action in low doses. 

Aspirin is an anti-inflammatory drug that acts as an inhibitor of an enzyme called cyclooxygenase (COX). It blocks both COX-1 and COX-1 enzymes which reduces the production of prostaglandins (PGs) (2). 

PGs are involved in pain and inflammation mediation. Aspirin also inhibits thromboxane A2 on platelets which prevents platelet aggregation (2). 

Therapeutic indications:

Trazodone is an FDA-approved drug for major depressive disorder (MDD). It is also used off-label for the following conditions (1):

  • insomnia
  • anxiety
  • Alzheimer’s disease
  • substance abuse
  • bulimia
  • fibromyalgia 

Aspirin is widely used for its analgesic, anti-inflammatory, and antiplatelet activity. Some of its therapeutic indications include (2): 

  • fever
  • angina pectoris
  • cardiovascular risk reduction
  • prevention and treatment of ischemic stroke
  • pain
  • prevention and treatment of myocardial infarction
  • osteoarthritis

Side effects:

Commonly reported side effects of trazodone include (1,3):

  • headache
  • dry mouth
  • fatigue
  • blurred vision
  • dizziness
  • constipation
  • drowsiness
  • QT prolongation
  • decreased concentration 
  • acid reflux
  • suicidal thoughts
  • visual hallucinations 
  • orthostatic hypotension
  • torsades
  • priapism

Some side effects of aspirin include (2):

  • hypersensitivity
  • nausea
  • vomiting
  • acid reflux
  • gastrointestinal upset
  • abdominal pain
  • increased risk of gastrointestinal bleeding 


Trazodone should not be taken together with monoamine oxidase inhibitors (MAOIs) because it can increase the risk of serotonin syndrome. Patients can initiate treatment with trazodone 14 days after stopping MAOIs (1). 

The risk of serotonin syndrome is also present while using other serotonergic drugs like triptans and tricyclic antidepressants. It should be used with caution in patients with liver and kidney impairments (1). 

Trazodone should be avoided in patients with QT prolongation and arrhythmia. It should not be administered with drugs that prolong QT interval (3). 

Aspirin is contraindicated in ibuprofen allergy. It should be used with caution in patients with asthma, peptic ulcer disease, and gastritis. It increases the risk of bleeding so it should not be used in patients with blood disorders (2). 

Can you use trazodone and aspirin together?

Using trazodone and aspirin together should be avoided because it increases the risk of bleeding (3). Aspirin prevents platelet aggregation and acts as a blood-thinning agent. Increased risk of bleeding is a common side effect of aspirin.

Trazodone is an anti-depressant with serotonergic activity. Antidepressants that block serotonin reuptake reduce serotonin concentration in the platelets. This reduces platelet aggregation and increases the risk of bleeding and bruising. 

Thus, trazodone and aspirin should not be taken together. If you suffer from fever or pain while taking trazodone, you must contact your healthcare provider for an appropriate prescription. 

As per my understanding, trazodone does not contain aspirin. Trazodone and aspirin are two different drugs. Trazodone is an antidepressant and a SARI. Aspirin is an NSAID and an anti-inflammatory drug. 

Both drugs have different mechanisms of action, uses, side effects, and contraindications. Concomitant use of trazodone and aspirin should be avoided due to the increased risk of bleeding. 


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Shin JJ, Saadabadi A. Trazodone. [Updated 2022 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


Arif H, Aggarwal S. Salicylic Acid (Aspirin) [Updated 2023 Jul 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


DESYREL® (trazodone hydrochloride).  U.S. Food and Drug Administration. Reference ID: 4119349 [Internet] [updated 2017 Jun; cited 2023 Dec 13]. Available from:

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