Does trazodone contain acetaminophen? (1+ active ingredient)

This article will answer the question, “Does trazodone contain acetaminophen?” We will be discussing the contents of trazodone, as well as drugs that contain acetaminophen.

Does trazodone contain acetaminophen? 

No, trazodone does not contain acetaminophen. Trazodone helps treat symptoms of depression, insomnia, sleep disorders, etc. It acts on serotonin reuptake transporters as well as serotonin receptors, hence increasing the levels of serotonin. (1)

Acetaminophen belongs to a class of analgesics and antipyretics which treat fever and pain. It is an over-the-counter drug which is easily available without any prescription, but trazodone is an only-prescription drug and should not be taken without the guidance of a physician. (2)

The use of trazodone is associated with side effects, which need proper monitoring and missing a dose or abrupt discontinuation of trazodone is associated with withdrawal symptoms, which is not seen in the case of drugs containing acetaminophen. 

What is the difference between trazodone and acetaminophen? 

Trazodone is also known by many brand names, including Desyrel. Trazodone is an active ingredient which acts on serotonin receptors and inhibits the reuptake of serotonin. Trazodone is also used to treat insomnia associated with antidepressant use. 

Acetaminophen is sold under the brand name Tylenol and is an over-the-counter drug which can be available without a prescription. Unlike trazodone, there are no monitoring requirements for acetaminophen. Prolonged use of acetaminophen can cause liver damage. If you are taking acetaminophen for an extended period, make sure to have a proper evaluation and consume it only when necessary.

Acetaminophen can be taken once daily to alleviate pain or fever and then discontinued, whereas trazodone needs tapering of the dose before discontinuing since it can cause withdrawal symptoms. The treatment with trazodone is always long-term to achieve the required effects.   

When not to use trazodone and acetaminophen? 

There are a few situations where you have to avoid taking trazodone and acetaminophen. Before taking any medication make sure you consult your physician for a proper assessment and management plan. 


  • Glaucoma
  • Epilepsy
  • Liver or kidney diseases
  • Pregnant or breastfeeding 
  • If you are taking certain medications such as blood thinners, anti-psychotics, stimulants, etc.


  • Liver disease
  • Kidney disease
  • Substance abuse
  • Stomach ulcers

How to use trazodone and acetaminophen safely and effectively? 

There are a few measures to follow in order to use trazodone and acetaminophen safely and effectively, such as:

  • Always consult a doctor before taking any medication, such as trazodone, since the dosage varies between individuals, and this medication needs monitoring for side effects. 
  • Trazodone interacts with other drugs, such as tramadol, other antidepressants, blood thinners, etc. and should be used with care.
  • Do not take acetaminophen for a longer duration, as it can damage your liver. Take it only when necessary. 
  • Trazodone can cause sedation; avoid taking it in the morning. 
  • A higher dose of acetaminophen can cause liver damage. Hence, monitor the dosage.
  • Some medications are available in combination with acetaminophen. Make sure you check the content before consuming it to avoid unnecessary double-dosing. 
  • Consult your healthcare professional if you are experiencing any side effects after taking the medication. 
  • Trazodone can cause side effects such as headache, fatigue, dizziness, dry mouth, orthostatic hypertension, suicidal thoughts, etc. (1)
  • Attend regular follow-ups to monitor for any side effects and to assess the treatment progression. 
  • Drugs such as trazodone need tapering before discontinuation to avoid withdrawal symptoms; if you are planning to stop the drug, consult your physician. 

As a pharmacist, I believe trazodone and acetaminophen are two separate active ingredients that have different mechanisms of action and treat different symptoms. It is important to know which medication treats what. Make sure you ask your physician about the drug when it is being prescribed to you. 

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Shin JJ, Saadabadi A. Trazodone. [Updated 2022 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: 


Gerriets V, Anderson J, Nappe TM. Acetaminophen. [Updated 2023 Jun 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: 

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