Does trazodone come in 200 mg tablet? (3+ dose)

This article will answer the question, “Does trazodone come in 200 mg tablets?” we will discuss the available dosage forms and strength of trazodone. 

Does trazodone come in 200 mg tablet? 

No, trazodone is not available in 200 mg tablets. The available dosage strengths of trazodone are 50mg, 100mg, 150mg and 300mg. There is no standard 200mg dosage strength of trazodone. (1,2)

Trazodone is an antidepressant of class serotonin-antagonist and reuptake inhibitor. Trazodone acts by two mechanisms: by inhibiting the reuptake transporters of serotonin and by acting directly on the serotonin receptors (type 2), which leads to an increase in serotonin levels and helps treat symptoms of depression, insomnia and sleep-related disorders. (2)

Trazodone is also available in the following dosage forms: (1,2)

• Tablet: 50mg, 100mg, 150mg, 300mg. 
• Capsules: 50mg, 100mg
• Liquid form: 10mg or 20mg in every 1ml

If you have been prescribed a dose of 200mg of trazodone a day, take two tablets of 100mg dose strength. Avoid taking too many tablets at a time as it may lead to overdose and will be harmful. Check the dosage strength before taking the medication to avoid double dosing. 

What does the research study suggest? 

Trazodone helps treat a variety of symptoms associated with depression, anxiety, insomnia associated with drug use, sleep-related disorders, etc. Research studies have shown that trazodone has shown positive results in treating nightmares and improving sleep in post-traumatic stress disorder (PTSD) patients. (2)

A survey done by M D Warner et al. found positive responses to trazodone in patients with PTSD suffering from insomnia and nightmares. In the study, 70% of the patients responded to a dose of 50-200mg of trazodone, while others could not tolerate a high dose of the drug. (3)

In another clinical study, trazodone 50-250mg was prescribed for two weeks in 9 patients diagnosed with major depressive disorder. The study reported improvement in sleep and symptoms of anxiety and depression. Finally, the study concluded that trazodone is effective in treating insomnia and symptoms of depression. (4)

What is the recommended dose of trazodone? 

The initial recommended dose of trazodone is 150mg. However, the dosing of trazodone varies between individuals as they respond to the drug in a specific manner. The dosing of trazodone ranges between 50mg and 300mg; if well tolerated, it can be titrated up to 600mg twice a day under observation. (2)

The administration of trazodone is started with 75mg to 150mg before bedtime (varies depending upon your condition). The dose is increased to 50mg every 3 to 4 days as per need. It should not exceed 600mg per day. Trazodone is recommended to be administered after meals to avoid lightheadedness and orthostatic hypertension. (1,2)

It is not recommended to self-medicate with antidepressants, as overdose or abrupt discontinuation of antidepressants can worsen your condition. Always consult a physician for a proper diagnosis and dosing of medication. 

What are the factors influencing trazodone dosing?

The dosing of trazodone can be influenced by some factors, such as: 

• Medical condition: The nature and severity of the illness determines the dosing of the drug.
• Individual response: Every individual responds to the drug in a different manner, and the dosing pattern of each individual varies depending upon their metabolism and response. 
• Age: Elderly patients need careful monitoring and low dosing because of reduced physiological functioning. 
• Weight: In some cases, weight can influence the dosing of medications. 
• Liver and kidney dysfunction: These organs play an important role in metabolising and eliminating the drug. Hence, dosage needs to be carefully managed. 
• Side effects: If you experience side effects at a particular dose, adjustment of the dose is required to avoid the side effects. 
• Concomitant medications: Trazodone can interact with other antidepressants, such as Lexapro, Cymbalta, etc. If an increased dose of trazodone is given in combination, it can cause serotonin syndrome. Hence, careful monitoring is required. 

What should you know before taking trazodone 200mg?

Trazodone is an antidepressant which helps treat symptoms of depression, sleep-related disorders, anxiety, Alzheimer’s disease, substance abuse, bulimia, PTSD and fibromyalgia. Trazodone is used in combination to treat insomnia caused by antidepressants such as Cymbalta, Lexapro, etc. 

Trazodone acts by increasing the level of serotonin in the brain, which helps elevate mood, concentration, attention, and other cognitive functions. Trazodone acts on serotonin 2A receptor, H1 receptor and alpha-1-adrenergic receptors, which helps in sedation. 

It is recommended to take trazodone in the evening or near bedtime and not in the morning because of its sedative effect. Concomitant use of trazodone with monoamine oxidase inhibitors, linezolid, triptans, tricyclic antidepressants, aspirin, NSAIDs and fentanyl is contraindicated. When taking trazodone in combination with other antidepressants, caution should be maintained as it can cause serotonin syndrome. 

Symptoms of serotonin syndrome can range from mild (nausea, vomiting, hypertension, increased heart rate, etc) to severe (seizures, tremors, altered mental status, rhabdomyolysis, shock, etc). If you are experiencing any side effects, seek medical help immediately. 

Monitor for side effects caused by trazodone, such as Headache, fatigue, dizziness, drowsiness, dry mouth, orthostatic hypertension, priapism, increased suicidal thoughts, and mania. 

Consult your physician before taking any OTC drug, as some of the medications interact with trazodone. Do not stop taking the drug without your physician’s guidance because trazodone has to be tapered before discontinuation to avoid withdrawal symptoms. 

As a pharmacist, I recommend checking the dose before consuming the drug to avoid double dosing. Accidental double dosing can lead to overdose, which can be harmful; you can avoid it with the help of a pill organiser, which will help you take the appropriate dose.

If you have accidentally consumed a double dose and the dose exceeds 600mg, visit your nearby hospital immediately; always take the drug as prescribed by your physician. 

References